Long noncoding RNAs in digestive system cancers: Functional roles, molecular mechanisms, and clinical implications (Review)

Long noncoding RNAs (lncRNAs) are emerging as new players in various diseases including cancer. LncRNAs have been shown to play multifaceted roles in the development, progression, and metastasis of cancer. In this review, we highlight the lncRNAs that are critically involved in the pathogenesis of d...

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Bibliographic Details
Published in:Oncology reports Vol. 36; no. 3; pp. 1207 - 1218
Main Authors: Fu, Min, Zou, Chen, Pan, Lei, Liang, Wei, Qian, Hui, Xu, Wenrong, Jiang, Pengcheng, Zhang, Xu
Format: Journal Article
Language:English
Published: Greece D.A. Spandidos 01.09.2016
Spandidos Publications
Spandidos Publications UK Ltd
Subjects:
Angiogenesis
Animals
biomarker
Biomarkers
Biomarkers, Tumor - genetics
Care and treatment
Cell adhesion & migration
Cell growth
Colorectal cancer
Development and progression
Digestive system
Digestive system cancer
Digestive System Neoplasms - genetics
Digestive System Neoplasms - pathology
Esophagus
Gallbladder
Gastric cancer
Gene expression
Gene Expression Regulation, Neoplastic - genetics
Genetic aspects
Health aspects
Humans
Liver cancer
long noncoding RNA
Medical prognosis
Metastasis
Pancreas
Prognosis
Properties
RNA
RNA, Long Noncoding - genetics
Roles
target
therapy
Transcription factors
ISSN:1021-335X, 1791-2431, 1791-2431
Online Access:Get full text
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Summary:Long noncoding RNAs (lncRNAs) are emerging as new players in various diseases including cancer. LncRNAs have been shown to play multifaceted roles in the development, progression, and metastasis of cancer. In this review, we highlight the lncRNAs that are critically involved in the pathogenesis of digestive system cancers (DSCs). We summarize the roles of the lncRNAs in DSCs and the underlying mechanisms responsible for their functions. The DSC-associated lncRNAs interact with a wide spectrum of molecules to regulate gene expression at transcriptional, post-transcriptional, and translational levels. We also provide new insights into the clinical significance of these lncRNAs, which are found to be closely associated with the aggressiveness of DSCs and could predict the prognosis of DSC patients. Moreover, lncRNAs have been suggested as promising therapeutic targets in DSCs. Therefore, better understanding of the functional roles of lncRNAs will provide new biomarkers for DSC diagnosis, prognosis, and therapy.
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ISSN:1021-335X
1791-2431
1791-2431
DOI:10.3892/or.2016.4929