Emerging therapeutic targets in metastatic progression: A focus on breast cancer

Metastasis is the underlying cause of death for the majority of breast cancer patients. Despite significant advances in recent years in basic research and clinical development, therapies that specifically target metastatic breast cancer remain inadequate, and represents the single greatest obstacle...

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Bibliographic Details
Published in:Pharmacology & therapeutics (Oxford) Vol. 161; pp. 79 - 96
Main Authors: Li, Zhuo, Kang, Yibin
Format: Journal Article
Language:English
Published: England 01.05.2016
Subjects:
Animals
Breast Neoplasms - drug therapy
Breast Neoplasms - secondary
Disease Progression
Humans
Immunotherapy - methods
Molecular Targeted Therapy - methods
Signal Transduction - drug effects
Tumor Microenvironment - drug effects
Breast cancer
Metastasis
Tumor microenvironment
Targeted therapy
Immunotherapy
ISSN:0163-7258, 1879-016X, 1879-016X
Online Access:Get full text
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Summary:Metastasis is the underlying cause of death for the majority of breast cancer patients. Despite significant advances in recent years in basic research and clinical development, therapies that specifically target metastatic breast cancer remain inadequate, and represents the single greatest obstacle to reducing mortality of late-stage breast cancer. Recent efforts have leveraged genomic analysis of breast cancer and molecular dissection of tumor-stromal cross-talk to uncover a number of promising candidates for targeted treatment of metastatic breast cancer. Rational combinations of therapeutic agents targeting tumor-intrinsic properties and microenvironmental components provide a promising strategy to develop precision treatments with higher specificity and less toxicity. In this review, we discuss the emerging therapeutic targets in breast cancer metastasis, from tumor-intrinsic pathways to those that involve the host tissue components, including the immune system.
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ISSN:0163-7258
1879-016X
1879-016X
DOI:10.1016/j.pharmthera.2016.03.003