Antiretroviral Preexposure Prophylaxis for Heterosexual HIV Transmission in Botswana

In this study, 1219 HIV-uninfected, heterosexual adults in Botswana were randomly assigned to tenofovir–emtricitabine (TDF–FTC) or placebo. The TDF–FTC group had a lower incidence of HIV infection but increased rates of side effects, including a significant loss of bone density. Biomedical strategie...

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Vydáno v:	The New England journal of medicine Ročník 367; číslo 5; s. 423 - 434
Hlavní autoři:	Thigpen, Michael C, Kebaabetswe, Poloko M, Paxton, Lynn A, Smith, Dawn K, Rose, Charles E, Segolodi, Tebogo M, Henderson, Faith L, Pathak, Sonal R, Soud, Fatma A, Chillag, Kata L, Mutanhaurwa, Rodreck, Chirwa, Lovemore Ian, Kasonde, Michael, Abebe, Daniel, Buliva, Evans, Gvetadze, Roman J, Johnson, Sandra, Sukalac, Thom, Thomas, Vasavi T, Hart, Clyde, Johnson, Jeffrey A, Malotte, C. Kevin, Hendrix, Craig W, Brooks, John T
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Waltham, MA Massachusetts Medical Society 02.08.2012
Témata:	Adenine - adverse effects Adenine - analogs & derivatives Adenine - therapeutic use Adolescent Adult Anti-Retroviral Agents - adverse effects Anti-Retroviral Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral agents Antiretroviral drugs Antiviral agents Biological and medical sciences Bone Density - drug effects Bone mineral density Contraception Behavior - statistics & numerical data Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Disease transmission Drug Resistance, Viral Drug Therapy, Combination Emtricitabine Female Gays & lesbians General aspects HIV HIV Infections - prevention & control HIV Seropositivity HIV-1 - genetics HIV-1 - isolation & purification HIV-2 - genetics HIV-2 - isolation & purification Human immunodeficiency virus Human viral diseases Humans Infections Infectious diseases Kaplan-Meier Estimate Male Medical research Medical sciences Mens health Motivation Nausea Organophosphonates - adverse effects Organophosphonates - therapeutic use Pharmacology. Drug treatments Prophylaxis Proportional Hazards Models RNA, Viral - blood Sexual Behavior - statistics & numerical data Tenofovir Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Vomiting Young Adult Botswana Africa Immunopathology Antiretroviral agent Heterosexuality Transmission Retroviridae AIDS Immune deficiency Lentivirus Infection Virus Medicine Prevention Preexposure Viral disease Antiviral Human immunodeficiency virus
ISSN:	0028-4793, 1533-4406, 1533-4406
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Shrnutí:	In this study, 1219 HIV-uninfected, heterosexual adults in Botswana were randomly assigned to tenofovir–emtricitabine (TDF–FTC) or placebo. The TDF–FTC group had a lower incidence of HIV infection but increased rates of side effects, including a significant loss of bone density. Biomedical strategies to prevent sexual transmission of human immunodeficiency virus (HIV) remain limited. 1 In animal models, preexposure prophylaxis with tenofovir disoproxil fumarate (TDF) or with the combination of TDF and emtricitabine (TDF–FTC) can prevent infections with HIV or hybrid simian–human immunodeficiency virus after vaginal or rectal challenge. 2 , 3 In humans, daily preexposure prophylaxis with TDF–FTC has been shown to reduce transmission of HIV by 44% among men who have sex with men 4 ; however, the findings from studies in heterosexual populations have been mixed. 5 – 8 Botswana has the world's second highest prevalence of HIV infection, estimated in 2008 to be . . .
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa1110711