Antiretroviral Preexposure Prophylaxis for Heterosexual HIV Transmission in Botswana

In this study, 1219 HIV-uninfected, heterosexual adults in Botswana were randomly assigned to tenofovir–emtricitabine (TDF–FTC) or placebo. The TDF–FTC group had a lower incidence of HIV infection but increased rates of side effects, including a significant loss of bone density. Biomedical strategie...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 367; no. 5; pp. 423 - 434
Main Authors:	Thigpen, Michael C, Kebaabetswe, Poloko M, Paxton, Lynn A, Smith, Dawn K, Rose, Charles E, Segolodi, Tebogo M, Henderson, Faith L, Pathak, Sonal R, Soud, Fatma A, Chillag, Kata L, Mutanhaurwa, Rodreck, Chirwa, Lovemore Ian, Kasonde, Michael, Abebe, Daniel, Buliva, Evans, Gvetadze, Roman J, Johnson, Sandra, Sukalac, Thom, Thomas, Vasavi T, Hart, Clyde, Johnson, Jeffrey A, Malotte, C. Kevin, Hendrix, Craig W, Brooks, John T
Format:	Journal Article
Language:	English
Published:	Waltham, MA Massachusetts Medical Society 02.08.2012
Subjects:	Adenine - adverse effects Adenine - analogs & derivatives Adenine - therapeutic use Adolescent Adult Anti-Retroviral Agents - adverse effects Anti-Retroviral Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral agents Antiretroviral drugs Antiviral agents Biological and medical sciences Bone Density - drug effects Bone mineral density Contraception Behavior - statistics & numerical data Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Disease transmission Drug Resistance, Viral Drug Therapy, Combination Emtricitabine Female Gays & lesbians General aspects HIV HIV Infections - prevention & control HIV Seropositivity HIV-1 - genetics HIV-1 - isolation & purification HIV-2 - genetics HIV-2 - isolation & purification Human immunodeficiency virus Human viral diseases Humans Infections Infectious diseases Kaplan-Meier Estimate Male Medical research Medical sciences Mens health Motivation Nausea Organophosphonates - adverse effects Organophosphonates - therapeutic use Pharmacology. Drug treatments Prophylaxis Proportional Hazards Models RNA, Viral - blood Sexual Behavior - statistics & numerical data Tenofovir Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Vomiting Young Adult Botswana Africa Immunopathology Antiretroviral agent Heterosexuality Transmission Retroviridae AIDS Immune deficiency Lentivirus Infection Virus Medicine Prevention Preexposure Viral disease Antiviral Human immunodeficiency virus
ISSN:	0028-4793, 1533-4406, 1533-4406
Online Access:	Get full text
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