Impact of chronic subthalamic high-frequency stimulation on metabolic basal ganglia activity: a 2-deoxyglucose uptake and cytochrome oxidase mRNA study in a macaque model of Parkinson's disease

The mechanisms of action of high‐frequency stimulation (HFS) of the subthalamic nucleus (STN) remain only partially understood. Hitherto, experimental studies have suggested that STN‐HFS reduces the activity of STN neurons. However, some recent reports have challenged this view, showing that STN‐HFS...

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Bibliographic Details
Published in:	The European journal of neuroscience Vol. 25; no. 5; pp. 1492 - 1500
Main Authors:	Meissner, Wassilios, Guigoni, Celine, Cirilli, Laetitia, Garret, Maurice, Bioulac, Bernard H., Gross, Christian E., Bezard, Erwan, Benazzouz, Abdelhamid
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01.03.2007
Subjects:	Animals basal ganglia Basal Ganglia - metabolism deep brain stimulation Deoxyglucose - metabolism Disease Models, Animal Dose-Response Relationship, Radiation Electric Stimulation Therapy - methods Electron Transport Complex IV - genetics Electron Transport Complex IV - metabolism Female Gene Expression Regulation - radiation effects globus pallidus internalis Macaca Macaca fascicularis motor thalamus Parkinsonian Disorders - metabolism Parkinsonian Disorders - pathology Parkinsonian Disorders - surgery Primates RNA, Messenger - metabolism Statistics, Nonparametric STN subthalamic nucleus Subthalamic Nucleus - physiopathology Subthalamic Nucleus - radiation effects
ISSN:	0953-816X, 1460-9568
Online Access:	Get full text
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