Prurigo pigmentosa: a clinicopathological study and analysis of associated factors

Background  Prurigo pigmentosa (PP), a rare inflammatory disease of the skin, is mostly reported in the ethnic Japanese population. Its pathogenesis remains unclear. The chronic and recurrent nature of PP implies a possible role of viral infection in the pathogenesis. The anti‐inflammatory mechanism...

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Veröffentlicht in:International journal of dermatology Jg. 50; H. 1; S. 36 - 43
Hauptverfasser: Lu, Pei-Hsuan, Hui, Rosaline C.-Y., Yang, Li-Cheng, Yang, Chih-Hsun, Chung, Wen-Hung
Format: Tagungsbericht Journal Article
Sprache:Englisch
Veröffentlicht: Oxford, UK Blackwell Publishing Ltd 01.01.2011
Blackwell
Schlagworte:
Adolescent
Adult
Anti-Bacterial Agents - therapeutic use
Biological and medical sciences
Biopsy
Dermatology
Doxycycline - therapeutic use
Female
Humans
Hyperpigmentation - drug therapy
Hyperpigmentation - virology
Immunohistochemistry
Interleukin-6 - metabolism
Interleukin-8 - metabolism
Male
Medical sciences
Middle Aged
Pigmentary diseases of the skin
Prurigo - drug therapy
Prurigo - pathology
Prurigo - virology
Recurrence
Retrospective Studies
Simplexvirus - isolation & purification
Young Adult
Skin disease
Pigmentation disorder
Dermatology
Risk factor
Prurigo pigmentosa
ISSN:0011-9059, 1365-4632, 1365-4632
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Zusammenfassung:Background  Prurigo pigmentosa (PP), a rare inflammatory disease of the skin, is mostly reported in the ethnic Japanese population. Its pathogenesis remains unclear. The chronic and recurrent nature of PP implies a possible role of viral infection in the pathogenesis. The anti‐inflammatory mechanism of doxycycline, which is well documented as a good treatment for PP, is related to the suppression of interleukin expression. Methods  We identified and retrospectively analyzed 16 biopsy‐proven and criteria‐matched patients over a seven year period at a single medical center. DNA extracted from formalin‐fixed, paraffin‐embedded specimens was analyzed for herpes simplex virus‐1 (HSV‐1), HSV‐2, and human herpes virus‐6 (HHV‐6) DNA by polymerase chain reaction. Immunohistochemistry was performed to determine the interleukin‐6 (IL‐6) and interleukin‐8 (IL‐8) expression in PP skin lesions. Results  Clinicopathological findings in the ethnic Chinese population are similar to those reported in Japanese studies. All patients had a good response to doxycycline treatment, with a mean duration of use of 2.4 weeks. However, recurrence was noted in six patients. HSV‐1, HSV‐2, and HHV‐6 DNA in PP skin lesions were negative. Immunohistochemistry showed IL‐6 (P = 0.035) to be more strongly expressed in PP skin lesions. There was no statistical significance of elevated IL‐8 expression in PP (P = 0.123). Conclusions  Prurigo pigmentosa is not uncommon in the ethnic Chinese population. There was no evidence of herpes virus DNA in PP skin lesions. Increased expression of IL‐6 in PP skin lesions may explain the effects of doxycycline in terms of its anti‐inflammatory properties.
Bibliographie:istex:860E160D61308D5E348B715B2A21A6F9D553A211
ark:/67375/WNG-48BNZ4QD-W
ArticleID:IJD4625
Conflicts of interest: None.
Funding: None.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0011-9059
1365-4632
1365-4632
DOI:10.1111/j.1365-4632.2010.04625.x