MicroRNA-33a functions as a bone metastasis suppressor in lung cancer by targeting parathyroid hormone related protein

Bone is a common site of metastasis for lung cancer, and is associated with significant morbidity and a dismal prognosis. MicroRNAs (miRNAs) are increasingly implicated in regulating the progression of malignancies. The efficacy of miR-33a or anti-miR-33a plasmid was assessed by Real-time PCR. Lucif...

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Veröffentlicht in:	Biochimica et biophysica acta Jg. 1830; H. 6; S. 3756 - 3766
Hauptverfasser:	Kuo, Po-Lin, Liao, Szi-Hui, Hung, Jen-Yu, Huang, Ming-Shyan, Hsu, Ya-Ling
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.06.2013
Schlagworte:	Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Bone Neoplasms - secondary bone resorption Bone Resorption - genetics Bone Resorption - metabolism Bone Resorption - pathology bones Cell Differentiation - genetics Cell Line, Tumor Down-Regulation - genetics enzyme-linked immunosorbent assay Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Humans interleukin-8 Interleukin-8 - biosynthesis Interleukin-8 - genetics luciferase Lung cancer lung neoplasms Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology macrophage colony-stimulating factor metastasis microRNA MicroRNAs - biosynthesis MicroRNAs - genetics mir-33a morbidity neoplasm cells Neoplasm Metastasis Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics OPG osteoblasts Osteoclastogenesis osteoclasts Osteoclasts - metabolism Osteoclasts - pathology Osteoprotegerin - biosynthesis Osteoprotegerin - genetics parathyroid hormone Parathyroid Hormone-Related Protein - biosynthesis Parathyroid Hormone-Related Protein - genetics patients plasmids prognosis PTHrP quantitative polymerase chain reaction RANK Ligand - biosynthesis RANK Ligand - genetics RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics secretion Osteoclastogenesis RANKL M-CSF mir-33a Lung cancer OPG Real-time qRT-PCR PTHrP
ISSN:	0304-4165, 0006-3002, 1872-8006
Online-Zugang:	Volltext
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