MicroRNA-33a functions as a bone metastasis suppressor in lung cancer by targeting parathyroid hormone related protein
Bone is a common site of metastasis for lung cancer, and is associated with significant morbidity and a dismal prognosis. MicroRNAs (miRNAs) are increasingly implicated in regulating the progression of malignancies. The efficacy of miR-33a or anti-miR-33a plasmid was assessed by Real-time PCR. Lucif...
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| Published in: | Biochimica et biophysica acta Vol. 1830; no. 6; pp. 3756 - 3766 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
01.06.2013
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| ISSN: | 0304-4165, 0006-3002, 1872-8006 |
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| Abstract | Bone is a common site of metastasis for lung cancer, and is associated with significant morbidity and a dismal prognosis. MicroRNAs (miRNAs) are increasingly implicated in regulating the progression of malignancies.
The efficacy of miR-33a or anti-miR-33a plasmid was assessed by Real-time PCR. Luciferase assays were using One-Glo Luciferase Assay System. Measurement of secreted factors was determined by ELISA kit.
We have found that miR-33a, which is downregulated in lung cancer cells, directly targets PTHrP (parathyroid hormone-related protein), a potent stimulator of osteoclastic bone resorption, leading to decreased osteolytic bone metastasis. We also found that miR-33a levels are inversely correlated with PTHrP expression between human normal bronchial cell line and lung cancer cell lines. The reintroduction of miR-33a reduces the stimulatory effect of A549 on the production of osteoclastogenesis activator RANKL (receptor activator of nuclear factor kappa-B ligand) and M-CSF (macrophage colony-stimulating factor) on osteoblasts, while the expression of PTHrP is decreased in A549 cells. miR-33a overexpression also reduces the inhibitory activity of A549 on the production of OPG (osteoprotegerin), an osteoclastogenesis inhibitor. In addition, miR-33a-mediated PTHrP downregulation results in decreased IL-8 secretion in A549, which contributes to decreased lung cancer-mediated osteoclast differentiation and bone resorption.
These findings have led us to conclude that miR-33a may be a potent tumor suppressor, which inhibits direct and indirect osteoclastogenesis through repression of PTHrP.
miR-33a may even predict a poor prognosis for lung cancer patients.
•miR-33a is downregulated in lung cancer cell lines.•miR-33a regulates the expression of PTHrP.•Overexpression of miR-33a decreases the induction of A549 on the production of RANKL and M-CSF in osteoblasts.•Ectopic expression of miR-33a decreases the stimulatory effect of A549 on osteoclastogenesis.•Knockdown of miR-33a triggers the inductive effect of BEAS-2B on the production of RANKL and M-CSF in osteoblasts. |
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| AbstractList | Bone is a common site of metastasis for lung cancer, and is associated with significant morbidity and a dismal prognosis. MicroRNAs (miRNAs) are increasingly implicated in regulating the progression of malignancies.BACKGROUNDBone is a common site of metastasis for lung cancer, and is associated with significant morbidity and a dismal prognosis. MicroRNAs (miRNAs) are increasingly implicated in regulating the progression of malignancies.The efficacy of miR-33a or anti-miR-33a plasmid was assessed by Real-time PCR. Luciferase assays were using One-Glo Luciferase Assay System. Measurement of secreted factors was determined by ELISA kit.METHODSThe efficacy of miR-33a or anti-miR-33a plasmid was assessed by Real-time PCR. Luciferase assays were using One-Glo Luciferase Assay System. Measurement of secreted factors was determined by ELISA kit.We have found that miR-33a, which is downregulated in lung cancer cells, directly targets PTHrP (parathyroid hormone-related protein), a potent stimulator of osteoclastic bone resorption, leading to decreased osteolytic bone metastasis. We also found that miR-33a levels are inversely correlated with PTHrP expression between human normal bronchial cell line and lung cancer cell lines. The reintroduction of miR-33a reduces the stimulatory effect of A549 on the production of osteoclastogenesis activator RANKL (receptor activator of nuclear factor kappa-B ligand) and M-CSF (macrophage colony-stimulating factor) on osteoblasts, while the expression of PTHrP is decreased in A549 cells. miR-33a overexpression also reduces the inhibitory activity of A549 on the production of OPG (osteoprotegerin), an osteoclastogenesis inhibitor. In addition, miR-33a-mediated PTHrP downregulation results in decreased IL-8 secretion in A549, which contributes to decreased lung cancer-mediated osteoclast differentiation and bone resorption.RESULTSWe have found that miR-33a, which is downregulated in lung cancer cells, directly targets PTHrP (parathyroid hormone-related protein), a potent stimulator of osteoclastic bone resorption, leading to decreased osteolytic bone metastasis. We also found that miR-33a levels are inversely correlated with PTHrP expression between human normal bronchial cell line and lung cancer cell lines. The reintroduction of miR-33a reduces the stimulatory effect of A549 on the production of osteoclastogenesis activator RANKL (receptor activator of nuclear factor kappa-B ligand) and M-CSF (macrophage colony-stimulating factor) on osteoblasts, while the expression of PTHrP is decreased in A549 cells. miR-33a overexpression also reduces the inhibitory activity of A549 on the production of OPG (osteoprotegerin), an osteoclastogenesis inhibitor. In addition, miR-33a-mediated PTHrP downregulation results in decreased IL-8 secretion in A549, which contributes to decreased lung cancer-mediated osteoclast differentiation and bone resorption.These findings have led us to conclude that miR-33a may be a potent tumor suppressor, which inhibits direct and indirect osteoclastogenesis through repression of PTHrP.CONCLUSIONSThese findings have led us to conclude that miR-33a may be a potent tumor suppressor, which inhibits direct and indirect osteoclastogenesis through repression of PTHrP.miR-33a may even predict a poor prognosis for lung cancer patients.GENERAL SIGNIFICANCEmiR-33a may even predict a poor prognosis for lung cancer patients. Bone is a common site of metastasis for lung cancer, and is associated with significant morbidity and a dismal prognosis. MicroRNAs (miRNAs) are increasingly implicated in regulating the progression of malignancies.The efficacy of miR-33a or anti-miR-33a plasmid was assessed by Real-time PCR. Luciferase assays were using One-Glo Luciferase Assay System. Measurement of secreted factors was determined by ELISA kit.We have found that miR-33a, which is downregulated in lung cancer cells, directly targets PTHrP (parathyroid hormone-related protein), a potent stimulator of osteoclastic bone resorption, leading to decreased osteolytic bone metastasis. We also found that miR-33a levels are inversely correlated with PTHrP expression between human normal bronchial cell line and lung cancer cell lines. The reintroduction of miR-33a reduces the stimulatory effect of A549 on the production of osteoclastogenesis activator RANKL (receptor activator of nuclear factor kappa-B ligand) and M-CSF (macrophage colony-stimulating factor) on osteoblasts, while the expression of PTHrP is decreased in A549 cells. miR-33a overexpression also reduces the inhibitory activity of A549 on the production of OPG (osteoprotegerin), an osteoclastogenesis inhibitor. In addition, miR-33a-mediated PTHrP downregulation results in decreased IL-8 secretion in A549, which contributes to decreased lung cancer-mediated osteoclast differentiation and bone resorption.These findings have led us to conclude that miR-33a may be a potent tumor suppressor, which inhibits direct and indirect osteoclastogenesis through repression of PTHrP.miR-33a may even predict a poor prognosis for lung cancer patients. Bone is a common site of metastasis for lung cancer, and is associated with significant morbidity and a dismal prognosis. MicroRNAs (miRNAs) are increasingly implicated in regulating the progression of malignancies. The efficacy of miR-33a or anti-miR-33a plasmid was assessed by Real-time PCR. Luciferase assays were using One-Glo Luciferase Assay System. Measurement of secreted factors was determined by ELISA kit. We have found that miR-33a, which is downregulated in lung cancer cells, directly targets PTHrP (parathyroid hormone-related protein), a potent stimulator of osteoclastic bone resorption, leading to decreased osteolytic bone metastasis. We also found that miR-33a levels are inversely correlated with PTHrP expression between human normal bronchial cell line and lung cancer cell lines. The reintroduction of miR-33a reduces the stimulatory effect of A549 on the production of osteoclastogenesis activator RANKL (receptor activator of nuclear factor kappa-B ligand) and M-CSF (macrophage colony-stimulating factor) on osteoblasts, while the expression of PTHrP is decreased in A549 cells. miR-33a overexpression also reduces the inhibitory activity of A549 on the production of OPG (osteoprotegerin), an osteoclastogenesis inhibitor. In addition, miR-33a-mediated PTHrP downregulation results in decreased IL-8 secretion in A549, which contributes to decreased lung cancer-mediated osteoclast differentiation and bone resorption. These findings have led us to conclude that miR-33a may be a potent tumor suppressor, which inhibits direct and indirect osteoclastogenesis through repression of PTHrP. miR-33a may even predict a poor prognosis for lung cancer patients. •miR-33a is downregulated in lung cancer cell lines.•miR-33a regulates the expression of PTHrP.•Overexpression of miR-33a decreases the induction of A549 on the production of RANKL and M-CSF in osteoblasts.•Ectopic expression of miR-33a decreases the stimulatory effect of A549 on osteoclastogenesis.•Knockdown of miR-33a triggers the inductive effect of BEAS-2B on the production of RANKL and M-CSF in osteoblasts. Bone is a common site of metastasis for lung cancer, and is associated with significant morbidity and a dismal prognosis. MicroRNAs (miRNAs) are increasingly implicated in regulating the progression of malignancies. The efficacy of miR-33a or anti-miR-33a plasmid was assessed by Real-time PCR. Luciferase assays were using One-Glo Luciferase Assay System. Measurement of secreted factors was determined by ELISA kit. We have found that miR-33a, which is downregulated in lung cancer cells, directly targets PTHrP (parathyroid hormone-related protein), a potent stimulator of osteoclastic bone resorption, leading to decreased osteolytic bone metastasis. We also found that miR-33a levels are inversely correlated with PTHrP expression between human normal bronchial cell line and lung cancer cell lines. The reintroduction of miR-33a reduces the stimulatory effect of A549 on the production of osteoclastogenesis activator RANKL (receptor activator of nuclear factor kappa-B ligand) and M-CSF (macrophage colony-stimulating factor) on osteoblasts, while the expression of PTHrP is decreased in A549 cells. miR-33a overexpression also reduces the inhibitory activity of A549 on the production of OPG (osteoprotegerin), an osteoclastogenesis inhibitor. In addition, miR-33a-mediated PTHrP downregulation results in decreased IL-8 secretion in A549, which contributes to decreased lung cancer-mediated osteoclast differentiation and bone resorption. These findings have led us to conclude that miR-33a may be a potent tumor suppressor, which inhibits direct and indirect osteoclastogenesis through repression of PTHrP. miR-33a may even predict a poor prognosis for lung cancer patients. BACKGROUND: Bone is a common site of metastasis for lung cancer, and is associated with significant morbidity and a dismal prognosis. MicroRNAs (miRNAs) are increasingly implicated in regulating the progression of malignancies. METHODS: The efficacy of miR-33a or anti-miR-33a plasmid was assessed by Real-time PCR. Luciferase assays were using One-Glo Luciferase Assay System. Measurement of secreted factors was determined by ELISA kit. RESULTS: We have found that miR-33a, which is downregulated in lung cancer cells, directly targets PTHrP (parathyroid hormone-related protein), a potent stimulator of osteoclastic bone resorption, leading to decreased osteolytic bone metastasis. We also found that miR-33a levels are inversely correlated with PTHrP expression between human normal bronchial cell line and lung cancer cell lines. The reintroduction of miR-33a reduces the stimulatory effect of A549 on the production of osteoclastogenesis activator RANKL (receptor activator of nuclear factor kappa-B ligand) and M-CSF (macrophage colony-stimulating factor) on osteoblasts, while the expression of PTHrP is decreased in A549 cells. miR-33a overexpression also reduces the inhibitory activity of A549 on the production of OPG (osteoprotegerin), an osteoclastogenesis inhibitor. In addition, miR-33a-mediated PTHrP downregulation results in decreased IL-8 secretion in A549, which contributes to decreased lung cancer-mediated osteoclast differentiation and bone resorption. CONCLUSIONS: These findings have led us to conclude that miR-33a may be a potent tumor suppressor, which inhibits direct and indirect osteoclastogenesis through repression of PTHrP. GENERAL SIGNIFICANCE: miR-33a may even predict a poor prognosis for lung cancer patients. |
| Author | Kuo, Po-Lin Huang, Ming-Shyan Hsu, Ya-Ling Liao, Szi-Hui Hung, Jen-Yu |
| Author_xml | – sequence: 1 givenname: Po-Lin surname: Kuo fullname: Kuo, Po-Lin organization: Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan – sequence: 2 givenname: Szi-Hui surname: Liao fullname: Liao, Szi-Hui organization: Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan – sequence: 3 givenname: Jen-Yu surname: Hung fullname: Hung, Jen-Yu organization: Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan – sequence: 4 givenname: Ming-Shyan surname: Huang fullname: Huang, Ming-Shyan organization: Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan – sequence: 5 givenname: Ya-Ling surname: Hsu fullname: Hsu, Ya-Ling email: hsuyl326@gmail.com organization: Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23458685$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1101/gad.1165404 10.1097/PPO.0b013e318258b743 10.1002/ijc.11586 10.1126/science.273.5275.613 10.1093/jnci/djr216 10.1146/annurev-biochem-060308-103103 10.1096/fj.04-1823fje 10.1371/journal.pone.0023199 10.1016/j.semcdb.2008.07.016 10.1002/cncr.10828 10.1007/s10555-006-9033-z 10.1093/carcin/bgq030 10.1210/endo.140.10.7037 10.1016/S0092-8674(00)81569-X 10.1038/onc.2011.278 10.1002/ijc.1425 10.1158/0008-5472.CAN-10-2993 10.1038/nature10661 10.1002/path.1199 10.1093/carcin/bgs100 10.1007/s10585-011-9398-4 10.1038/nrc1997 10.3322/caac.20121 10.1378/chest.09-1358 10.1016/S0104-4230(12)70190-2 10.3109/17453674.2011.552779 10.1016/j.bone.2010.07.015 10.1074/jbc.M111.256156 10.1126/science.1189123 10.1097/JTO.0b013e318229421f 10.1016/S8756-3282(99)00121-0 10.1007/s00223-012-9600-y 10.2337/db11-0944 10.1080/02841860600635870 |
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| Keywords | Osteoclastogenesis RANKL M-CSF mir-33a Lung cancer OPG Real-time qRT-PCR PTHrP |
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| References | Jansen, Vermeer, Bloemen, Stap, Everts (bb0055) 2012; 90 Tao, Okamoto, Nishikawa, Yoshikawa, Myoui (bb0165) 2011; 6 McGrath (bb0155) 2011; 6 Pine, Mechanic, Enewold, Chaturvedi, Katki, Zheng, Bowman, Engels, Caporaso, Harris (bb0180) 2011; 103 Wijesekara, Zhang, Kang, Abraham, Bhattacharjee, Warnock, Verchere, Hayden (bb0090) 2012; 61 Miki, Yano, Hanibuchi, Kanematsu, Muguruma, Sone (bb0120) 2004; 108 Kitazawa, Kitazawa (bb0040) 2002; 198 Thomas, Lange-Grünweller, Weirauch, Gutsch, Aigner, Grünweller, Hartmann (bb0095) 2012; 31 Calin, Croce (bb0075) 2006; 6 Yasuda, Shima, Nakagawa, Yamaguchi, Kinosaki, Goto, Mochizuki, Tsuda, Morinaga, Udagawa, Takahashi, Suda, Higashio (bb0050) 1999; 25 Fabian, Sonenberg, Filipowicz (bb0070) 2010; 79 Zükin (bb0010) 2012; 58 Roato, Grano, Brunetti, Colucci, Mussa, Bertetto, Ferracini (bb0160) 2005; 19 Boeri, Pastorino, Sozzi (bb0110) 2012; 268 Hsu, Huang, Yang, Hung, Wu, Kuo (bb0140) 2011; 286 Lacey, Timms, Tan, Kelley, Dunstan, Burgess, Elliott, Colombero, Elliott, Scully, Hsu, Sullivan, Hawkins, Davy, Capparelli, Eli, Qian, Kaufman, Sarosi, Shalhoub, Senaldi, Guo, Delaney, Boyle (bb0060) 1998; 93 Lu, Govindan, Wang, Liu, Goodgame, Wen, Sezhiyan, Pfeifer, Li, Hua, Wang, Yang, You (bb0105) 2012; 33 Weiss, Wedin (bb0015) 2011; 82 Gujral, Burton, Terkeltaub, Deftos (bb0100) 2001; 61 Mountzios, Dimopoulos, Bamias, Papadopoulos, Kastritis, Syrigos, Pavlakis, Terpos (bb0150) 2007; 46 Monego, Lauriola, Ramella, D'Angelillo, Lanza, Granone, Ranelletti (bb0115) 2010; 137 Sims, Gooi (bb0030) 2008; 19 Furugaki, Moriya, Iwai, Yorozu, Yanagisawa, Kondoh, Fujimoto-Ohuchi, Mori (bb0145) 2011; 2 Johnson, Nguyen, Padalecki, Grubbs, Merkel, Oyajobi, Matrisian, Mundy, Sterling (bb0130) 2011; 71 Rove, Crawford (bb0020) 2009; 23 Hiraki, Ueoka, Bessho, Segawa, Takigawa, Kiura, Eguchi, Yoneda, Tanimoto, Harada (bb0035) 2002; 95 Thomas, Guise, Yin, Elliott, Horwood, Martin, Gillespie (bb0045) 1999; 140 Vortkamp, Lee, Lanske, Segre, Kronenberg, Tabin (bb0125) 1996; 273 Iguchi, Onuma, Sato, Sato, Ogata (bb0175) 2001; 94 Siegel, Ward, Brawley, Jemal (bb0005) 2011; 61 Sterling, Edwards, Martin, Mundy (bb0025) 2011; 48 Hsu, Hung, Ko, Hung, Huang, Kuo (bb0185) 2010; 31 Liao, McCauley (bb0170) 2006; 25 Vella, Choi, Lin, Reinert, Slack (bb0065) 2004; 18 Png, Halberg, Yoshida, Tavazoie (bb0080) 2011; 481 Najafi-Shoushtari, Kristo, Li, Shioda, Cohen, Gerszten, Näär (bb0085) 2010; 328 Najafi-Shoushtari (10.1016/j.bbagen.2013.02.022_bb0085) 2010; 328 Johnson (10.1016/j.bbagen.2013.02.022_bb0130) 2011; 71 Thomas (10.1016/j.bbagen.2013.02.022_bb0095) 2012; 31 Siegel (10.1016/j.bbagen.2013.02.022_bb0005) 2011; 61 Hiraki (10.1016/j.bbagen.2013.02.022_bb0035) 2002; 95 Lu (10.1016/j.bbagen.2013.02.022_bb0105) 2012; 33 Boeri (10.1016/j.bbagen.2013.02.022_bb0110) 2012; 268 Pine (10.1016/j.bbagen.2013.02.022_bb0180) 2011; 103 McGrath (10.1016/j.bbagen.2013.02.022_bb0155) 2011; 6 Vortkamp (10.1016/j.bbagen.2013.02.022_bb0125) 1996; 273 Weiss (10.1016/j.bbagen.2013.02.022_bb0015) 2011; 82 Gujral (10.1016/j.bbagen.2013.02.022_bb0100) 2001; 61 Zükin (10.1016/j.bbagen.2013.02.022_bb0010) 2012; 58 Kitazawa (10.1016/j.bbagen.2013.02.022_bb0040) 2002; 198 Png (10.1016/j.bbagen.2013.02.022_bb0080) 2011; 481 Hsu (10.1016/j.bbagen.2013.02.022_bb0185) 2010; 31 Hsu (10.1016/j.bbagen.2013.02.022_bb0140) 2011; 286 Fabian (10.1016/j.bbagen.2013.02.022_bb0070) 2010; 79 Wijesekara (10.1016/j.bbagen.2013.02.022_bb0090) 2012; 61 Sims (10.1016/j.bbagen.2013.02.022_bb0030) 2008; 19 Vella (10.1016/j.bbagen.2013.02.022_bb0065) 2004; 18 Thomas (10.1016/j.bbagen.2013.02.022_bb0045) 1999; 140 Mountzios (10.1016/j.bbagen.2013.02.022_bb0150) 2007; 46 Jansen (10.1016/j.bbagen.2013.02.022_bb0055) 2012; 90 Monego (10.1016/j.bbagen.2013.02.022_bb0115) 2010; 137 Rove (10.1016/j.bbagen.2013.02.022_bb0020) 2009; 23 Sterling (10.1016/j.bbagen.2013.02.022_bb0025) 2011; 48 Lacey (10.1016/j.bbagen.2013.02.022_bb0060) 1998; 93 Calin (10.1016/j.bbagen.2013.02.022_bb0075) 2006; 6 Furugaki (10.1016/j.bbagen.2013.02.022_bb0145) 2011; 2 Yasuda (10.1016/j.bbagen.2013.02.022_bb0050) 1999; 25 Tao (10.1016/j.bbagen.2013.02.022_bb0165) 2011; 6 Liao (10.1016/j.bbagen.2013.02.022_bb0170) 2006; 25 Roato (10.1016/j.bbagen.2013.02.022_bb0160) 2005; 19 Iguchi (10.1016/j.bbagen.2013.02.022_bb0175) 2001; 94 Miki (10.1016/j.bbagen.2013.02.022_bb0120) 2004; 108 |
| References_xml | – volume: 82 start-page: 96 year: 2011 end-page: 101 ident: bb0015 article-title: Surgery for skeletal metastases in lung cancer publication-title: Acta Orthop. – volume: 6 start-page: 1468 year: 2011 end-page: 1473 ident: bb0155 article-title: OPG/RANKL/RANK pathway as a therapeutic target in cancer publication-title: J. Thorac. Oncol. – volume: 71 start-page: 822 year: 2011 end-page: 831 ident: bb0130 article-title: TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling publication-title: Cancer Res. – volume: 19 start-page: 444 year: 2008 end-page: 451 ident: bb0030 article-title: Bone remodeling: multiple cellular interactions required for coupling of bone formation and resorption publication-title: Semin. Cell Dev. Biol. – volume: 328 start-page: 1566 year: 2010 end-page: 1569 ident: bb0085 article-title: MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis publication-title: Science – volume: 19 start-page: 228 year: 2005 end-page: 230 ident: bb0160 article-title: Mechanisms of spontaneous osteoclastogenesis in cancer with bone involvement publication-title: FASEB J. – volume: 48 start-page: 6 year: 2011 end-page: 15 ident: bb0025 article-title: Advances in the biology of bone metastasis: how the skeleton affects tumor behavior publication-title: Bone – volume: 481 start-page: 190 year: 2011 end-page: 194 ident: bb0080 article-title: A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells publication-title: Nature – volume: 93 start-page: 165 year: 1998 end-page: 176 ident: bb0060 article-title: Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation publication-title: Cell – volume: 31 start-page: 918 year: 2012 end-page: 928 ident: bb0095 article-title: The proto-oncogene Pim-1 is a target of miR-33a publication-title: Oncogene – volume: 137 start-page: 898 year: 2010 end-page: 908 ident: bb0115 article-title: Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 expression in human lung adenocarcinoma. Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 expression in human lung adenocarcinoma publication-title: Chest – volume: 198 start-page: 228 year: 2002 end-page: 236 ident: bb0040 article-title: RANK ligand is a prerequisite for cancer-associated osteolytic lesions publication-title: J. Pathol. – volume: 61 start-page: 212 year: 2011 end-page: 236 ident: bb0005 article-title: Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths publication-title: CA Cancer J. Clin. – volume: 6 start-page: 857 year: 2006 end-page: 866 ident: bb0075 article-title: MicroRNA signatures in human cancers publication-title: Nat. Rev. Cancer – volume: 33 start-page: 1046 year: 2012 end-page: 1054 ident: bb0105 article-title: MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer publication-title: Carcinogenesis – volume: 25 start-page: 559 year: 2006 end-page: 571 ident: bb0170 article-title: Skeletal metastasis: established and emerging roles of parathyroid hormone related protein (PTHrP) publication-title: Cancer Metastasis Rev. – volume: 61 start-page: 653 year: 2012 end-page: 658 ident: bb0090 article-title: miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets publication-title: Diabetes – volume: 94 start-page: 24 year: 2001 end-page: 27 ident: bb0175 article-title: Involvement of parathyroid hormone-related protein in experimental cachexia induced by a human lung cancer-derived cell line established from a bone metastasis specimen publication-title: Int. J. Cancer – volume: 2 start-page: 649 year: 2011 end-page: 659 ident: bb0145 article-title: Erlotinib inhibits osteolytic bone invasion of human non-small-cell lung cancer cell line NCI-H292 publication-title: Clin. Exp. Metastasis – volume: 273 start-page: 613 year: 1996 end-page: 622 ident: bb0125 article-title: Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein publication-title: Science – volume: 23 start-page: 21 year: 2009 end-page: 27 ident: bb0020 article-title: Metastatic cancer in solid tumors and clinical outcome: skeletal-related events publication-title: Oncology (Williston Park) – volume: 268 start-page: 268 year: 2012 end-page: 274 ident: bb0110 article-title: Role of microRNAs in lung cancer: microRNA signatures in cancer prognosis publication-title: Cancer J. – volume: 95 start-page: 1706 year: 2002 end-page: 1713 ident: bb0035 article-title: Parathyroid hormone-related protein measured at the time of first visit is an indicator of bone metastases and survival in lung carcinoma patients with hypercalcemia publication-title: Cancer – volume: 46 start-page: 221 year: 2007 end-page: 229 ident: bb0150 article-title: Abnormal bone remodeling process is due to an imbalance in the receptor activator of nuclear factor-kappaB ligand (RANKL)/osteoprotegerin (OPG) axis in patients with solid tumors metastatic to the skeleton publication-title: Acta Oncol. – volume: 286 start-page: 37335 year: 2011 end-page: 37346 ident: bb0140 article-title: Lung tumor-associated osteoblast-derived bone morphogenetic protein-2 increased epithelial-to-mesenchymal transition of cancer by Runx2/Snail signaling pathway publication-title: J. Biol. Chem. – volume: 31 start-page: 587 year: 2010 end-page: 596 ident: bb0185 article-title: Phospholipase D signaling pathway is involved in lung cancer-derived IL-8 increased osteoclastogenesis publication-title: Carcinogenesis – volume: 61 start-page: 2282 year: 2001 end-page: 2288 ident: bb0100 article-title: Parathyroid hormone-related protein induces interleukin 8 production by prostate cancer cells via a novel intracrine mechanism not mediated by its classical nuclear localization sequence publication-title: Cancer Res. – volume: 140 start-page: 4451 year: 1999 end-page: 4458 ident: bb0045 article-title: Breast cancer cells interact with osteoblasts to support osteoclast formation publication-title: Endocrinology – volume: 90 start-page: 515 year: 2012 end-page: 522 ident: bb0055 article-title: Osteoclast fusion and fission publication-title: Calcif. Tissue Int. – volume: 6 start-page: e23199 year: 2011 ident: bb0165 article-title: P38 mitogen-activated protein kinase inhibitor, FR167653, inhibits parathyroid hormone related protein-induced osteoclastogenesis and bone resorption publication-title: PLoS One – volume: 58 start-page: 263 year: 2012 end-page: 268 ident: bb0010 article-title: Epidermal growth factor receptor inhibitors in non-small cell lung cancer: current status and future perspectives publication-title: Rev. Assoc. Med. Bras. – volume: 25 start-page: 109 year: 1999 end-page: 113 ident: bb0050 article-title: A novel molecular mechanism modulating osteoclast differentiation and function publication-title: Bone – volume: 18 start-page: 132 year: 2004 end-page: 137 ident: bb0065 article-title: The publication-title: Genes Dev. – volume: 108 start-page: 511 year: 2004 end-page: 515 ident: bb0120 article-title: Parathyroid hormone-related protein (PTHrP) is responsible for production of bone metastasis, but not visceral metastasis, by human small cell lung cancer SBC-5 cells in natural killer cell-depleted SCID mice publication-title: Int. J. Cancer – volume: 79 start-page: 351 year: 2010 end-page: 379 ident: bb0070 article-title: Regulation of mRNA translation and stability by microRNAs publication-title: Annu. Rev. Biochem. – volume: 103 start-page: 1112 year: 2011 end-page: 1122 ident: bb0180 article-title: Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer publication-title: J. Natl. Cancer Inst. – volume: 18 start-page: 132 year: 2004 ident: 10.1016/j.bbagen.2013.02.022_bb0065 article-title: The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR publication-title: Genes Dev. doi: 10.1101/gad.1165404 – volume: 268 start-page: 268 year: 2012 ident: 10.1016/j.bbagen.2013.02.022_bb0110 article-title: Role of microRNAs in lung cancer: microRNA signatures in cancer prognosis publication-title: Cancer J. doi: 10.1097/PPO.0b013e318258b743 – volume: 108 start-page: 511 year: 2004 ident: 10.1016/j.bbagen.2013.02.022_bb0120 article-title: Parathyroid hormone-related protein (PTHrP) is responsible for production of bone metastasis, but not visceral metastasis, by human small cell lung cancer SBC-5 cells in natural killer cell-depleted SCID mice publication-title: Int. J. Cancer doi: 10.1002/ijc.11586 – volume: 273 start-page: 613 year: 1996 ident: 10.1016/j.bbagen.2013.02.022_bb0125 article-title: Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein publication-title: Science doi: 10.1126/science.273.5275.613 – volume: 103 start-page: 1112 year: 2011 ident: 10.1016/j.bbagen.2013.02.022_bb0180 article-title: Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer publication-title: J. Natl. Cancer Inst. doi: 10.1093/jnci/djr216 – volume: 79 start-page: 351 year: 2010 ident: 10.1016/j.bbagen.2013.02.022_bb0070 article-title: Regulation of mRNA translation and stability by microRNAs publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev-biochem-060308-103103 – volume: 19 start-page: 228 year: 2005 ident: 10.1016/j.bbagen.2013.02.022_bb0160 article-title: Mechanisms of spontaneous osteoclastogenesis in cancer with bone involvement publication-title: FASEB J. doi: 10.1096/fj.04-1823fje – volume: 6 start-page: e23199 year: 2011 ident: 10.1016/j.bbagen.2013.02.022_bb0165 article-title: P38 mitogen-activated protein kinase inhibitor, FR167653, inhibits parathyroid hormone related protein-induced osteoclastogenesis and bone resorption publication-title: PLoS One doi: 10.1371/journal.pone.0023199 – volume: 19 start-page: 444 year: 2008 ident: 10.1016/j.bbagen.2013.02.022_bb0030 article-title: Bone remodeling: multiple cellular interactions required for coupling of bone formation and resorption publication-title: Semin. Cell Dev. Biol. doi: 10.1016/j.semcdb.2008.07.016 – volume: 95 start-page: 1706 year: 2002 ident: 10.1016/j.bbagen.2013.02.022_bb0035 article-title: Parathyroid hormone-related protein measured at the time of first visit is an indicator of bone metastases and survival in lung carcinoma patients with hypercalcemia publication-title: Cancer doi: 10.1002/cncr.10828 – volume: 25 start-page: 559 year: 2006 ident: 10.1016/j.bbagen.2013.02.022_bb0170 article-title: Skeletal metastasis: established and emerging roles of parathyroid hormone related protein (PTHrP) publication-title: Cancer Metastasis Rev. doi: 10.1007/s10555-006-9033-z – volume: 31 start-page: 587 year: 2010 ident: 10.1016/j.bbagen.2013.02.022_bb0185 article-title: Phospholipase D signaling pathway is involved in lung cancer-derived IL-8 increased osteoclastogenesis publication-title: Carcinogenesis doi: 10.1093/carcin/bgq030 – volume: 140 start-page: 4451 year: 1999 ident: 10.1016/j.bbagen.2013.02.022_bb0045 article-title: Breast cancer cells interact with osteoblasts to support osteoclast formation publication-title: Endocrinology doi: 10.1210/endo.140.10.7037 – volume: 93 start-page: 165 year: 1998 ident: 10.1016/j.bbagen.2013.02.022_bb0060 article-title: Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation publication-title: Cell doi: 10.1016/S0092-8674(00)81569-X – volume: 31 start-page: 918 year: 2012 ident: 10.1016/j.bbagen.2013.02.022_bb0095 article-title: The proto-oncogene Pim-1 is a target of miR-33a publication-title: Oncogene doi: 10.1038/onc.2011.278 – volume: 94 start-page: 24 year: 2001 ident: 10.1016/j.bbagen.2013.02.022_bb0175 article-title: Involvement of parathyroid hormone-related protein in experimental cachexia induced by a human lung cancer-derived cell line established from a bone metastasis specimen publication-title: Int. J. Cancer doi: 10.1002/ijc.1425 – volume: 71 start-page: 822 year: 2011 ident: 10.1016/j.bbagen.2013.02.022_bb0130 article-title: TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-10-2993 – volume: 481 start-page: 190 year: 2011 ident: 10.1016/j.bbagen.2013.02.022_bb0080 article-title: A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells publication-title: Nature doi: 10.1038/nature10661 – volume: 23 start-page: 21 year: 2009 ident: 10.1016/j.bbagen.2013.02.022_bb0020 article-title: Metastatic cancer in solid tumors and clinical outcome: skeletal-related events publication-title: Oncology (Williston Park) – volume: 198 start-page: 228 year: 2002 ident: 10.1016/j.bbagen.2013.02.022_bb0040 article-title: RANK ligand is a prerequisite for cancer-associated osteolytic lesions publication-title: J. Pathol. doi: 10.1002/path.1199 – volume: 33 start-page: 1046 year: 2012 ident: 10.1016/j.bbagen.2013.02.022_bb0105 article-title: MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer publication-title: Carcinogenesis doi: 10.1093/carcin/bgs100 – volume: 2 start-page: 649 year: 2011 ident: 10.1016/j.bbagen.2013.02.022_bb0145 article-title: Erlotinib inhibits osteolytic bone invasion of human non-small-cell lung cancer cell line NCI-H292 publication-title: Clin. Exp. Metastasis doi: 10.1007/s10585-011-9398-4 – volume: 6 start-page: 857 year: 2006 ident: 10.1016/j.bbagen.2013.02.022_bb0075 article-title: MicroRNA signatures in human cancers publication-title: Nat. Rev. Cancer doi: 10.1038/nrc1997 – volume: 61 start-page: 212 year: 2011 ident: 10.1016/j.bbagen.2013.02.022_bb0005 article-title: Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths publication-title: CA Cancer J. Clin. doi: 10.3322/caac.20121 – volume: 137 start-page: 898 year: 2010 ident: 10.1016/j.bbagen.2013.02.022_bb0115 publication-title: Chest doi: 10.1378/chest.09-1358 – volume: 58 start-page: 263 year: 2012 ident: 10.1016/j.bbagen.2013.02.022_bb0010 article-title: Epidermal growth factor receptor inhibitors in non-small cell lung cancer: current status and future perspectives publication-title: Rev. Assoc. Med. Bras. doi: 10.1016/S0104-4230(12)70190-2 – volume: 82 start-page: 96 year: 2011 ident: 10.1016/j.bbagen.2013.02.022_bb0015 article-title: Surgery for skeletal metastases in lung cancer publication-title: Acta Orthop. doi: 10.3109/17453674.2011.552779 – volume: 48 start-page: 6 year: 2011 ident: 10.1016/j.bbagen.2013.02.022_bb0025 article-title: Advances in the biology of bone metastasis: how the skeleton affects tumor behavior publication-title: Bone doi: 10.1016/j.bone.2010.07.015 – volume: 286 start-page: 37335 year: 2011 ident: 10.1016/j.bbagen.2013.02.022_bb0140 article-title: Lung tumor-associated osteoblast-derived bone morphogenetic protein-2 increased epithelial-to-mesenchymal transition of cancer by Runx2/Snail signaling pathway publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.256156 – volume: 328 start-page: 1566 year: 2010 ident: 10.1016/j.bbagen.2013.02.022_bb0085 article-title: MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis publication-title: Science doi: 10.1126/science.1189123 – volume: 61 start-page: 2282 year: 2001 ident: 10.1016/j.bbagen.2013.02.022_bb0100 article-title: Parathyroid hormone-related protein induces interleukin 8 production by prostate cancer cells via a novel intracrine mechanism not mediated by its classical nuclear localization sequence publication-title: Cancer Res. – volume: 6 start-page: 1468 year: 2011 ident: 10.1016/j.bbagen.2013.02.022_bb0155 article-title: OPG/RANKL/RANK pathway as a therapeutic target in cancer publication-title: J. Thorac. Oncol. doi: 10.1097/JTO.0b013e318229421f – volume: 25 start-page: 109 year: 1999 ident: 10.1016/j.bbagen.2013.02.022_bb0050 article-title: A novel molecular mechanism modulating osteoclast differentiation and function publication-title: Bone doi: 10.1016/S8756-3282(99)00121-0 – volume: 90 start-page: 515 year: 2012 ident: 10.1016/j.bbagen.2013.02.022_bb0055 article-title: Osteoclast fusion and fission publication-title: Calcif. Tissue Int. doi: 10.1007/s00223-012-9600-y – volume: 61 start-page: 653 year: 2012 ident: 10.1016/j.bbagen.2013.02.022_bb0090 article-title: miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets publication-title: Diabetes doi: 10.2337/db11-0944 – volume: 46 start-page: 221 year: 2007 ident: 10.1016/j.bbagen.2013.02.022_bb0150 article-title: Abnormal bone remodeling process is due to an imbalance in the receptor activator of nuclear factor-kappaB ligand (RANKL)/osteoprotegerin (OPG) axis in patients with solid tumors metastatic to the skeleton publication-title: Acta Oncol. doi: 10.1080/02841860600635870 |
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| Snippet | Bone is a common site of metastasis for lung cancer, and is associated with significant morbidity and a dismal prognosis. MicroRNAs (miRNAs) are increasingly... BACKGROUND: Bone is a common site of metastasis for lung cancer, and is associated with significant morbidity and a dismal prognosis. MicroRNAs (miRNAs) are... |
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| SubjectTerms | Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Bone Neoplasms - secondary bone resorption Bone Resorption - genetics Bone Resorption - metabolism Bone Resorption - pathology bones Cell Differentiation - genetics Cell Line, Tumor Down-Regulation - genetics enzyme-linked immunosorbent assay Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Humans interleukin-8 Interleukin-8 - biosynthesis Interleukin-8 - genetics luciferase Lung cancer lung neoplasms Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology macrophage colony-stimulating factor metastasis microRNA MicroRNAs - biosynthesis MicroRNAs - genetics mir-33a morbidity neoplasm cells Neoplasm Metastasis Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics OPG osteoblasts Osteoclastogenesis osteoclasts Osteoclasts - metabolism Osteoclasts - pathology Osteoprotegerin - biosynthesis Osteoprotegerin - genetics parathyroid hormone Parathyroid Hormone-Related Protein - biosynthesis Parathyroid Hormone-Related Protein - genetics patients plasmids prognosis PTHrP quantitative polymerase chain reaction RANK Ligand - biosynthesis RANK Ligand - genetics RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics secretion |
| Title | MicroRNA-33a functions as a bone metastasis suppressor in lung cancer by targeting parathyroid hormone related protein |
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