Inflammation and depression in young people: a systematic review and proposed inflammatory pathways

Depression onset peaks during adolescence and young adulthood. Current treatments are only moderately effective, driving the search for novel pathophysiological mechanisms underlying youth depression. Inflammatory dysregulation has been shown in adults with depression, however, less is known about i...

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Bibliographic Details
Published in:Molecular psychiatry Vol. 27; no. 1; pp. 315 - 327
Main Authors: Toenders, Yara J, Laskaris, Liliana, Davey, Christopher G, Berk, Michael, Milaneschi, Yuri, Lamers, Femke, Penninx, Brenda W J H, Schmaal, Lianne
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.01.2022
Subjects:
Adolescent
Adult
Depression - therapy
Humans
Inflammation
Longitudinal Studies
Mental depression
Systematic review
Young Adult
ISSN:1359-4184, 1476-5578, 1476-5578
Online Access:Get full text
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Summary:Depression onset peaks during adolescence and young adulthood. Current treatments are only moderately effective, driving the search for novel pathophysiological mechanisms underlying youth depression. Inflammatory dysregulation has been shown in adults with depression, however, less is known about inflammation in youth depression. This systematic review identified 109 studies examining the association between inflammation and youth depression and showed subtle evidence for inflammatory dysregulation in youth depression. Longitudinal studies support the bidirectional association between inflammation and depression in youth. We hypothesise multiple inflammatory pathways contributing to depression. More research is needed on anti-inflammatory treatments, potentially tailored to individual symptom profiles.
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ISSN:1359-4184
1476-5578
1476-5578
DOI:10.1038/s41380-021-01306-8