Inflammation and depression in young people: a systematic review and proposed inflammatory pathways

Depression onset peaks during adolescence and young adulthood. Current treatments are only moderately effective, driving the search for novel pathophysiological mechanisms underlying youth depression. Inflammatory dysregulation has been shown in adults with depression, however, less is known about i...

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Vydáno v:Molecular psychiatry Ročník 27; číslo 1; s. 315 - 327
Hlavní autoři: Toenders, Yara J, Laskaris, Liliana, Davey, Christopher G, Berk, Michael, Milaneschi, Yuri, Lamers, Femke, Penninx, Brenda W J H, Schmaal, Lianne
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Nature Publishing Group 01.01.2022
Témata:
Adolescent
Adult
Depression - therapy
Humans
Inflammation
Longitudinal Studies
Mental depression
Systematic review
Young Adult
ISSN:1359-4184, 1476-5578, 1476-5578
On-line přístup:Získat plný text
Tagy: Přidat tag
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Abstract Depression onset peaks during adolescence and young adulthood. Current treatments are only moderately effective, driving the search for novel pathophysiological mechanisms underlying youth depression. Inflammatory dysregulation has been shown in adults with depression, however, less is known about inflammation in youth depression. This systematic review identified 109 studies examining the association between inflammation and youth depression and showed subtle evidence for inflammatory dysregulation in youth depression. Longitudinal studies support the bidirectional association between inflammation and depression in youth. We hypothesise multiple inflammatory pathways contributing to depression. More research is needed on anti-inflammatory treatments, potentially tailored to individual symptom profiles.
AbstractList Depression onset peaks during adolescence and young adulthood. Current treatments are only moderately effective, driving the search for novel pathophysiological mechanisms underlying youth depression. Inflammatory dysregulation has been shown in adults with depression, however, less is known about inflammation in youth depression. This systematic review identified 109 studies examining the association between inflammation and youth depression and showed subtle evidence for inflammatory dysregulation in youth depression. Longitudinal studies support the bidirectional association between inflammation and depression in youth. We hypothesise multiple inflammatory pathways contributing to depression. More research is needed on anti-inflammatory treatments, potentially tailored to individual symptom profiles.
Depression onset peaks during adolescence and young adulthood. Current treatments are only moderately effective, driving the search for novel pathophysiological mechanisms underlying youth depression. Inflammatory dysregulation has been shown in adults with depression, however, less is known about inflammation in youth depression. This systematic review identified 109 studies examining the association between inflammation and youth depression and showed subtle evidence for inflammatory dysregulation in youth depression. Longitudinal studies support the bidirectional association between inflammation and depression in youth. We hypothesise multiple inflammatory pathways contributing to depression. More research is needed on anti-inflammatory treatments, potentially tailored to individual symptom profiles.Depression onset peaks during adolescence and young adulthood. Current treatments are only moderately effective, driving the search for novel pathophysiological mechanisms underlying youth depression. Inflammatory dysregulation has been shown in adults with depression, however, less is known about inflammation in youth depression. This systematic review identified 109 studies examining the association between inflammation and youth depression and showed subtle evidence for inflammatory dysregulation in youth depression. Longitudinal studies support the bidirectional association between inflammation and depression in youth. We hypothesise multiple inflammatory pathways contributing to depression. More research is needed on anti-inflammatory treatments, potentially tailored to individual symptom profiles.
Author Lamers, Femke
Davey, Christopher G
Milaneschi, Yuri
Berk, Michael
Laskaris, Liliana
Penninx, Brenda W J H
Schmaal, Lianne
Toenders, Yara J
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  givenname: Yara J
  orcidid: 0000-0002-4117-1143
  surname: Toenders
  fullname: Toenders, Yara J
  organization: Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia
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  surname: Laskaris
  fullname: Laskaris, Liliana
  organization: Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia
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  givenname: Christopher G
  orcidid: 0000-0003-1431-3852
  surname: Davey
  fullname: Davey, Christopher G
  organization: Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia
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  surname: Berk
  fullname: Berk, Michael
  organization: Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia
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  orcidid: 0000-0001-9822-048X
  surname: Schmaal
  fullname: Schmaal, Lianne
  email: lianne.schmaal@unimelb.edu.au, lianne.schmaal@unimelb.edu.au
  organization: Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. lianne.schmaal@unimelb.edu.au
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Snippet Depression onset peaks during adolescence and young adulthood. Current treatments are only moderately effective, driving the search for novel...
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SubjectTerms Adolescent
Adult
Depression - therapy
Humans
Inflammation
Longitudinal Studies
Mental depression
Systematic review
Young Adult
Title Inflammation and depression in young people: a systematic review and proposed inflammatory pathways
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