“Parkinson-dementia” diseases: A comparison by double tracer SPECT studies

We performed 123I-FP-CIT/SPECT and ECD/SPECT in 30 patients with Parkinson's disease with dementia (PDD) and 30 patients with dementia with Lewy bodies (DLB) to evaluate whether presynaptic nigro-striatal function and/or cerebral perfusional pattern is different in these diseases. The striatal...

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Published in:Parkinsonism & related disorders Vol. 15; no. 10; pp. 762 - 766
Main Authors: Rossi, Carlo, Volterrani, Duccio, Nicoletti, Valentina, Manca, Gianpiero, Frosini, Daniela, Kiferle, Lorenzo, Unti, Elisa, De Feo, Paola, Bonuccelli, Ubaldo, Ceravolo, Roberto
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.12.2009
Subjects:
Aged
Aged, 80 and over
Brain Mapping
Cerebrovascular Circulation - physiology
Corpus Striatum - diagnostic imaging
Corpus Striatum - physiopathology
Dementia - complications
Dementia - diagnostic imaging
Dementia with Lewy bodies
Diterpenes, Clerodane
Female
Humans
Iodine Radioisotopes
Lewy Body Disease - complications
Lewy Body Disease - diagnostic imaging
Male
Neurology
Parkinson disease
Parkinson Disease - complications
Parkinson Disease - diagnostic imaging
Severity of Illness Index
SPECT
Tomography, Emission-Computed, Single-Photon
Tropanes
Parkinson disease
SPECT
Dementia with Lewy bodies
ISSN:1353-8020, 1873-5126, 1873-5126
Online Access:Get full text
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Summary:We performed 123I-FP-CIT/SPECT and ECD/SPECT in 30 patients with Parkinson's disease with dementia (PDD) and 30 patients with dementia with Lewy bodies (DLB) to evaluate whether presynaptic nigro-striatal function and/or cerebral perfusional pattern is different in these diseases. The striatal uptake of DAT tracer was statistically significantly lower in PDD and DLB with respect to control data ( p < 0.0005), however no significant difference was found between PDD and DLB. Patients with PDD and DLB showed a significant reduction of rCBF ( p < 0.001) in parieto-occipital and frontal areas, with respect to controls, but the comparison between the two groups did not result in any significant difference by SPM analysis. Finally no correlation was found between any regional perfusional changes and nigro-striatal dysfunction. We conclude that neither studies with 123I-FP-CIT nor ECD/SPECT were able to discriminate between DLB and PDD in vivo.
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ISSN:1353-8020
1873-5126
1873-5126
DOI:10.1016/j.parkreldis.2009.05.012