“Parkinson-dementia” diseases: A comparison by double tracer SPECT studies

We performed 123I-FP-CIT/SPECT and ECD/SPECT in 30 patients with Parkinson's disease with dementia (PDD) and 30 patients with dementia with Lewy bodies (DLB) to evaluate whether presynaptic nigro-striatal function and/or cerebral perfusional pattern is different in these diseases. The striatal...

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Veröffentlicht in:	Parkinsonism & related disorders Jg. 15; H. 10; S. 762 - 766
Hauptverfasser:	Rossi, Carlo, Volterrani, Duccio, Nicoletti, Valentina, Manca, Gianpiero, Frosini, Daniela, Kiferle, Lorenzo, Unti, Elisa, De Feo, Paola, Bonuccelli, Ubaldo, Ceravolo, Roberto
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.12.2009
Schlagworte:	Aged Aged, 80 and over Brain Mapping Cerebrovascular Circulation - physiology Corpus Striatum - diagnostic imaging Corpus Striatum - physiopathology Dementia - complications Dementia - diagnostic imaging Dementia with Lewy bodies Diterpenes, Clerodane Female Humans Iodine Radioisotopes Lewy Body Disease - complications Lewy Body Disease - diagnostic imaging Male Neurology Parkinson disease Parkinson Disease - complications Parkinson Disease - diagnostic imaging Severity of Illness Index SPECT Tomography, Emission-Computed, Single-Photon Tropanes Parkinson disease SPECT Dementia with Lewy bodies
ISSN:	1353-8020, 1873-5126, 1873-5126
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Abstract	We performed 123I-FP-CIT/SPECT and ECD/SPECT in 30 patients with Parkinson's disease with dementia (PDD) and 30 patients with dementia with Lewy bodies (DLB) to evaluate whether presynaptic nigro-striatal function and/or cerebral perfusional pattern is different in these diseases. The striatal uptake of DAT tracer was statistically significantly lower in PDD and DLB with respect to control data ( p < 0.0005), however no significant difference was found between PDD and DLB. Patients with PDD and DLB showed a significant reduction of rCBF ( p < 0.001) in parieto-occipital and frontal areas, with respect to controls, but the comparison between the two groups did not result in any significant difference by SPM analysis. Finally no correlation was found between any regional perfusional changes and nigro-striatal dysfunction. We conclude that neither studies with 123I-FP-CIT nor ECD/SPECT were able to discriminate between DLB and PDD in vivo.
AbstractList	We performed 123I-FP-CIT/SPECT and ECD/SPECT in 30 patients with Parkinson's disease with dementia (PDD) and 30 patients with dementia with Lewy bodies (DLB) to evaluate whether presynaptic nigro-striatal function and/or cerebral perfusional pattern is different in these diseases. The striatal uptake of DAT tracer was statistically significantly lower in PDD and DLB with respect to control data ( p < 0.0005), however no significant difference was found between PDD and DLB. Patients with PDD and DLB showed a significant reduction of rCBF ( p < 0.001) in parieto-occipital and frontal areas, with respect to controls, but the comparison between the two groups did not result in any significant difference by SPM analysis. Finally no correlation was found between any regional perfusional changes and nigro-striatal dysfunction. We conclude that neither studies with 123I-FP-CIT nor ECD/SPECT were able to discriminate between DLB and PDD in vivo. Abstract We performed 123I-FP-CIT/SPECT and ECD/SPECT in 30 patients with Parkinson's disease with dementia (PDD) and 30 patients with dementia with Lewy bodies (DLB) to evaluate whether presynaptic nigro-striatal function and/or cerebral perfusional pattern is different in these diseases. The striatal uptake of DAT tracer was statistically significantly lower in PDD and DLB with respect to control data ( p < 0.0005), however no significant difference was found between PDD and DLB. Patients with PDD and DLB showed a significant reduction of rCBF ( p < 0.001) in parieto-occipital and frontal areas, with respect to controls, but the comparison between the two groups did not result in any significant difference by SPM analysis. Finally no correlation was found between any regional perfusional changes and nigro-striatal dysfunction. We conclude that neither studies with 123I-FP-CIT nor ECD/SPECT were able to discriminate between DLB and PDD in vivo. We performed 123I-FP-CIT/SPECT and ECD/SPECT in 30 patients with Parkinson's disease with dementia (PDD) and 30 patients with dementia with Lewy bodies (DLB) to evaluate whether presynaptic nigro-striatal function and/or cerebral perfusional pattern is different in these diseases. The striatal uptake of DAT tracer was statistically significantly lower in PDD and DLB with respect to control data (p < 0.0005), however no significant difference was found between PDD and DLB. Patients with PDD and DLB showed a significant reduction of rCBF (p < 0.001) in parieto-occipital and frontal areas, with respect to controls, but the comparison between the two groups did not result in any significant difference by SPM analysis. Finally no correlation was found between any regional perfusional changes and nigro-striatal dysfunction. We conclude that neither studies with 123I-FP-CIT nor ECD/SPECT were able to discriminate between DLB and PDD in vivo. We performed 123I-FP-CIT/SPECT and ECD/SPECT in 30 patients with Parkinson's disease with dementia (PDD) and 30 patients with dementia with Lewy bodies (DLB) to evaluate whether presynaptic nigro-striatal function and/or cerebral perfusional pattern is different in these diseases. The striatal uptake of DAT tracer was statistically significantly lower in PDD and DLB with respect to control data (p < 0.0005), however no significant difference was found between PDD and DLB. Patients with PDD and DLB showed a significant reduction of rCBF (p < 0.001) in parieto-occipital and frontal areas, with respect to controls, but the comparison between the two groups did not result in any significant difference by SPM analysis. Finally no correlation was found between any regional perfusional changes and nigro-striatal dysfunction. We conclude that neither studies with 123I-FP-CIT nor ECD/SPECT were able to discriminate between DLB and PDD in vivo.We performed 123I-FP-CIT/SPECT and ECD/SPECT in 30 patients with Parkinson's disease with dementia (PDD) and 30 patients with dementia with Lewy bodies (DLB) to evaluate whether presynaptic nigro-striatal function and/or cerebral perfusional pattern is different in these diseases. The striatal uptake of DAT tracer was statistically significantly lower in PDD and DLB with respect to control data (p < 0.0005), however no significant difference was found between PDD and DLB. Patients with PDD and DLB showed a significant reduction of rCBF (p < 0.001) in parieto-occipital and frontal areas, with respect to controls, but the comparison between the two groups did not result in any significant difference by SPM analysis. Finally no correlation was found between any regional perfusional changes and nigro-striatal dysfunction. We conclude that neither studies with 123I-FP-CIT nor ECD/SPECT were able to discriminate between DLB and PDD in vivo.
Author	Manca, Gianpiero Rossi, Carlo Nicoletti, Valentina Kiferle, Lorenzo Unti, Elisa Ceravolo, Roberto Volterrani, Duccio De Feo, Paola Bonuccelli, Ubaldo Frosini, Daniela
Author_xml	– sequence: 1 givenname: Carlo surname: Rossi fullname: Rossi, Carlo organization: Department of Neuroscience, Neurology Section, University of Pisa, Via Roma, 67, 56126 Pisa, Italy – sequence: 2 givenname: Duccio surname: Volterrani fullname: Volterrani, Duccio organization: Nuclear Medicine Service, University of Pisa, Via Roma, 67, 56126 Pisa, Italy – sequence: 3 givenname: Valentina surname: Nicoletti fullname: Nicoletti, Valentina organization: Department of Neuroscience, Neurology Section, University of Pisa, Via Roma, 67, 56126 Pisa, Italy – sequence: 4 givenname: Gianpiero surname: Manca fullname: Manca, Gianpiero organization: Nuclear Medicine Service, University of Pisa, Via Roma, 67, 56126 Pisa, Italy – sequence: 5 givenname: Daniela surname: Frosini fullname: Frosini, Daniela organization: Department of Neuroscience, Neurology Section, University of Pisa, Via Roma, 67, 56126 Pisa, Italy – sequence: 6 givenname: Lorenzo surname: Kiferle fullname: Kiferle, Lorenzo organization: Department of Neuroscience, Neurology Section, University of Pisa, Via Roma, 67, 56126 Pisa, Italy – sequence: 7 givenname: Elisa surname: Unti fullname: Unti, Elisa organization: Department of Neuroscience, Neurology Section, University of Pisa, Via Roma, 67, 56126 Pisa, Italy – sequence: 8 givenname: Paola surname: De Feo fullname: De Feo, Paola organization: Department of Neuroscience, Neurology Section, University of Pisa, Via Roma, 67, 56126 Pisa, Italy – sequence: 9 givenname: Ubaldo surname: Bonuccelli fullname: Bonuccelli, Ubaldo organization: Department of Neuroscience, Neurology Section, University of Pisa, Via Roma, 67, 56126 Pisa, Italy – sequence: 10 givenname: Roberto surname: Ceravolo fullname: Ceravolo, Roberto email: r.ceravolo@med.unipi.it organization: Department of Neuroscience, Neurology Section, University of Pisa, Via Roma, 67, 56126 Pisa, Italy
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Snippet	We performed 123I-FP-CIT/SPECT and ECD/SPECT in 30 patients with Parkinson's disease with dementia (PDD) and 30 patients with dementia with Lewy bodies (DLB)... Abstract We performed 123I-FP-CIT/SPECT and ECD/SPECT in 30 patients with Parkinson's disease with dementia (PDD) and 30 patients with dementia with Lewy...
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SubjectTerms	Aged Aged, 80 and over Brain Mapping Cerebrovascular Circulation - physiology Corpus Striatum - diagnostic imaging Corpus Striatum - physiopathology Dementia - complications Dementia - diagnostic imaging Dementia with Lewy bodies Diterpenes, Clerodane Female Humans Iodine Radioisotopes Lewy Body Disease - complications Lewy Body Disease - diagnostic imaging Male Neurology Parkinson disease Parkinson Disease - complications Parkinson Disease - diagnostic imaging Severity of Illness Index SPECT Tomography, Emission-Computed, Single-Photon Tropanes
Title	“Parkinson-dementia” diseases: A comparison by double tracer SPECT studies
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