A pilot study of alternative substrates in the critically Ill subject using a ketogenic feed

Bioenergetic failure caused by impaired utilisation of glucose and fatty acids contributes to organ dysfunction across multiple tissues in critical illness. Ketone bodies may form an alternative substrate source, but the feasibility and safety of inducing a ketogenic state in physiologically unstabl...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 8345 - 14
Main Authors:	McNelly, Angela, Langan, Anne, Bear, Danielle E., Page, Alexandria, Martin, Tim, Seidu, Fatima, Santos, Filipa, Rooney, Kieron, Liang, Kaifeng, Heales, Simon J., Baldwin, Tomas, Alldritt, Isabelle, Crossland, Hannah, Atherton, Philip J., Wilkinson, Daniel, Montgomery, Hugh, Prowle, John, Pearse, Rupert, Eaton, Simon, Puthucheary, Zudin A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 15.12.2023 Nature Publishing Group Nature Portfolio
Subjects:	101/58 692/308/153 692/308/2779/109/1940 692/308/575 Adult Amino acids Bioenergetics Clinical trials Critical Illness Diarrhea Enteral feeding Enteral nutrition Failure Fatty acids Feasibility studies Feeding Glucose Homeostasis Hospitals Humanities and Social Sciences Humans Illnesses Intensive Care Units Ketone Bodies Ketones Ketosis Metabolism multidisciplinary Pilot Projects Retention Safety Science Science (multidisciplinary) Substrates
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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