Identification of neoantigens for individualized therapeutic cancer vaccines

Somatic mutations in cancer cells can generate tumour-specific neoepitopes, which are recognized by autologous T cells in the host. As neoepitopes are not subject to central immune tolerance and are not expressed in healthy tissues, they are attractive targets for therapeutic cancer vaccines. Becaus...

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Bibliographic Details

Published in:	Nature reviews. Drug discovery Vol. 21; no. 4; pp. 261 - 282
Main Authors:	Lang, Franziska, Schrörs, Barbara, Löwer, Martin, Türeci, Özlem, Sahin, Ugur
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.04.2022
Subjects:	Antigens, Neoplasm - genetics Cancer Cancer Vaccines Humans Immunotherapy Mutation Neoplasms - genetics Neoplasms - therapy T-Lymphocytes Vaccines
ISSN:	1474-1776, 1474-1784, 1474-1784
Online Access:	Get full text
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