TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury

Toll-like receptors (TLRs) can orchestrate an inflammatory response upon activation by pathogen-associated motifs and release of endogenous stress ligands during tissue injury. The kidney constitutively expresses most TLRs, including TLR4. The function of TLR4 during the inflammation, tubular atroph...

Full description

Bibliographic Details

Published in:	Journal of the American Society of Nephrology Vol. 21; no. 8; p. 1299
Main Authors:	Pulskens, Wilco P, Rampanelli, Elena, Teske, Gwendoline J, Butter, Loes M, Claessen, Nike, Luirink, Ilse K, van der Poll, Tom, Florquin, Sandrine, Leemans, Jaklien C
Format:	Journal Article
Language:	English
Published:	United States 01.08.2010
Subjects:	Animals Disease Progression Fibrosis - etiology Kidney - pathology Kidney Tubules - pathology Mice Renal Insufficiency - pathology Toll-Like Receptor 4 - physiology
ISSN:	1533-3450, 1533-3450
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!