TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury

Toll-like receptors (TLRs) can orchestrate an inflammatory response upon activation by pathogen-associated motifs and release of endogenous stress ligands during tissue injury. The kidney constitutively expresses most TLRs, including TLR4. The function of TLR4 during the inflammation, tubular atroph...

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Veröffentlicht in:	Journal of the American Society of Nephrology Jg. 21; H. 8; S. 1299
Hauptverfasser:	Pulskens, Wilco P, Rampanelli, Elena, Teske, Gwendoline J, Butter, Loes M, Claessen, Nike, Luirink, Ilse K, van der Poll, Tom, Florquin, Sandrine, Leemans, Jaklien C
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.08.2010
Schlagworte:	Animals Disease Progression Fibrosis - etiology Kidney - pathology Kidney Tubules - pathology Mice Renal Insufficiency - pathology Toll-Like Receptor 4 - physiology
ISSN:	1533-3450, 1533-3450
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