Influence of the pH Synthesis of Fe3O4 Magnetic Nanoparticles on Their Applicability for Magnetic Hyperthermia: An In Vitro Analysis

Nanotechnology, specifically magnetic nanoparticles (MNPs), is revolutionizing cancer treatment. Magnetic hyperthermia is a treatment that, using MNPs, can selectively kill cancer cells without causing damage to the surrounding tissues. Background/Objectives: This work aimed to analyze how the synth...

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Veröffentlicht in:Pharmaceutics Jg. 17; H. 7; S. 844
Hauptverfasser: Costa, Bárbara, Pereira, Eurico, Ferreira-Filho, Vital C., Pires, Ana Salomé, Pereira, Laura C. J., Soares, Paula I. P., Botelho, Maria Filomena, Mendes, Fernando, Graça, Manuel P. F., Teixeira, Sílvia Soreto
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Basel MDPI AG 27.06.2025
MDPI
Schlagworte:
Antibiotics
Cancer therapies
Caustic soda
Chloride
Cytotoxicity
Efficiency
Glioma
hydrothermal synthesis
Hyperthermia
magnetic hyperthermia
magnetite
Morphology
Nanoparticles
NaOH
Reagents
SAR
Sodium
Temperature
Transmission electron microscopy
Tumors
United States > US
Germany
ISSN:1999-4923, 1999-4923
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Zusammenfassung:Nanotechnology, specifically magnetic nanoparticles (MNPs), is revolutionizing cancer treatment. Magnetic hyperthermia is a treatment that, using MNPs, can selectively kill cancer cells without causing damage to the surrounding tissues. Background/Objectives: This work aimed to analyze how the synthesis conditions, namely, how the pH of the reaction can influence the magnetic properties of Fe3O4 nanoparticles for magnetic hyperthermia, using the hydrothermal synthesis. Methods: For the hydrothermal synthesis, FeCl3·6H2O and FeCl2·4H2O were mixed with different quantities of NaOH to adjust the pH. After obtaining a black precipitate, the samples were placed in an autoclave at 200 °C for 60 h, followed by a washing and drying phase. The obtained MNPs were analyzed using X-Ray Diffraction (XRD), Transmission Electron Microscopy, a Superconducting Quantum Interference Device, Specific Absorption Rate analysis, and cytotoxicity assays. Results: Different MNPs were analyzed (9.06 < pH < 12.75). The XRD results showed the presence of various iron oxide phases (magnetite, maghemite, and hematite), resulting from the oxidization of the iron phases present in the autoclave. In terms of the average particle size, it was verified that, by increasing the pH value, the size decreases (from 53.53 nm to 9.49 nm). Additionally, MNPs possess a superparamagnetic behaviour with high SAR values (above 69.3 W/g). Conclusions: It was found that the pH of the reaction can influence the size, morphology, magnetization, and thermal efficiency of the MNP. The MNP with the highest composition of Fe3O4 was synthesized with a pH of 12.75, with a cubic morphology and a SAR value of 92.7 ± 3.2 W/g.
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ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics17070844