A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss

Inhibition of Notch signalling with a gamma-secretase inhibitor (GSI) induces mammalian hair cell regeneration and partial hearing restoration. In this proof-of-concept Phase I/IIa multiple-ascending dose open-label trial (ISRCTN59733689), adults with mild-moderate sensorineural hearing loss receive...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 1896 - 9
Main Authors:	Schilder, Anne G. M., Wolpert, Stephan, Saeed, Shakeel, Middelink, Leonie M., Edge, Albert S. B., Blackshaw, Helen, Pastiadis, Kostas, Bibas, Athanasios G.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.03.2024 Nature Publishing Group Nature Portfolio
Subjects:	631/378/1687 631/378/2619/1533 692/308 692/700/565 Adult Adults Aged Amplitudes Amyloid Precursor Protein Secretases Animal models Audiometry, Pure-Tone Auditory system Auditory Threshold - physiology Effectiveness Hearing Hearing loss Hearing Loss, Sensorineural - drug therapy Humanities and Social Sciences Humans Inhibitors multidisciplinary Otoacoustic emissions Otoacoustic Emissions, Spontaneous - physiology Safety Science Science (multidisciplinary) Secretase Thresholds
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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