Anti-inflammatory Effects of Siponimod in a Mouse Model of Excitotoxicity-Induced Retinal Injury

Glaucoma is a leading cause of permanent blindness worldwide and is characterized by neurodegeneration linked to progressive retinal ganglion cell (RGC) death, axonal damage, and neuroinflammation. Glutamate excitotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors plays a crucial role i...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Molecular neurobiology Ročník 60; číslo 12; s. 7222 - 7237
Hlavní autoři:	Basavarajappa, Devaraj, Gupta, Vivek, Chitranshi, Nitin, Viswanathan, Deepa, Gupta, Veer, Vander Wall, Roshana, Palanivel, Viswanthram, Mirzaei, Mehdi, You, Yuyi, Klistorner, Alexander, Graham, Stuart L.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Springer US 01.12.2023 Springer Nature B.V
Témata:	Animals Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Biomedical and Life Sciences Biomedicine Cell activation Cell Biology Cell death Central nervous system Excitotoxicity Glaucoma Glaucoma - metabolism Glial cells Glutamic acid receptors Glutamic acid receptors (ionotropic) Immunomodulation Inflammasomes Inflammation Mice Molecular modelling Multiple sclerosis N-Methyl-D-aspartic acid receptors N-Methylaspartate - metabolism Neurobiology Neurodegeneration Neuroinflammatory Diseases Neurology Neurosciences Neurotoxicity NF-κB protein Nitric-oxide synthase Oral administration Receptors, N-Methyl-D-Aspartate - metabolism Retina Retina - metabolism Retinal ganglion cells Sphingosine 1-phosphate Sphingosine 1-phosphate receptors Structure-function relationships Up-regulation Glaucoma Excitotoxicity Sphingosine-1-phosphate NMDA Neuroinflammation Inflammasome Glia Siponimod
ISSN:	0893-7648, 1559-1182, 1559-1182
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!