The NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure

Corticosteroid binding globulin (CBG; SERPINA6 ) binds >85% of circulating glucocorticoids but its influence on their metabolic actions is unproven. Targeted proteolytic cleavage of CBG by neutrophil elastase (NE; ELANE ) significantly reduces CBG binding affinity, potentially increasing ‘free’ g...

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Bibliographic Details
Published in:	Nature communications Vol. 16; no. 1; pp. 545 - 16
Main Authors:	Boyle, Luke D., Miguelez-Crespo, Allende, Paul, Mhairi, Villalobos, Elisa, Toews, Julia N. C., Ivatt, Lisa, Nagy, Boglarka, Magennis, Marisa, Homer, Natalie Z. M., Andrew, Ruth, Viau, Victor, Hammond, Geoffrey L., Stimson, Roland H., Walker, Brian R., Nixon, Mark
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 09.01.2025 Nature Publishing Group Nature Portfolio
Subjects:	45/77 45/88 45/90 631/443/319/1557 631/443/319/1642 631/443/319/2723 64/110 82/58 Adipose tissue Adipose Tissue - metabolism Adult alpha 1-Antitrypsin - genetics alpha 1-Antitrypsin - metabolism Animals Binding Bioavailability Body fat Circulation Diet, High-Fat Elastase Female Globulins Glucocorticoids Glucocorticoids - metabolism Glucose tolerance High fat diet Humanities and Social Sciences Humans Hypothalamic-pituitary-adrenal axis Inflammation Insulin Resistance Intra-Abdominal Fat - metabolism Leukocyte Elastase - genetics Leukocyte Elastase - metabolism Leukocytes (neutrophilic) Male Metabolism Mice Mice, Inbred C57BL Mice, Knockout Middle Aged multidisciplinary Mutation Neutrophils Proteolysis Science Science (multidisciplinary) Steroids Transcortin - genetics Transcortin - metabolism
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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