Identification of a hyperinflammatory sepsis phenotype using protein biomarker and clinical data in the ProCESS randomized trial

Sepsis is a heterogeneous syndrome and phenotypes have been proposed using clinical data. Less is known about the contribution of protein biomarkers to clinical sepsis phenotypes and their importance for treatment effects in randomized trials of resuscitation. The objective is to use both clinical a...

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Bibliographic Details
Published in:	Scientific reports Vol. 14; no. 1; pp. 6234 - 8
Main Authors:	DeMerle, Kimberley M., Kennedy, Jason N., Chang, Chung-Chou H., Delucchi, Kevin, Huang, David T., Kravitz, Max S., Shapiro, Nathan I., Yealy, Donald M., Angus, Derek C., Calfee, Carolyn S., Seymour, Christopher W.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14.03.2024 Nature Publishing Group Nature Portfolio
Subjects:	631/114/1305 692/308/53/2422 Bilirubin Biomarkers Clinical Protocols Clinical trials Genotype & phenotype Heterogeneity Humanities and Social Sciences Humans Latent class analysis Mortality multidisciplinary Patients Phenotype Phenotypes Proteins Science Science (multidisciplinary) Secondary analysis Sepsis Sepsis - diagnosis Sepsis - therapy Septic shock Shock, Septic - diagnosis Shock, Septic - therapy Biomarkers Sepsis Phenotypes
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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