Carbogen breathing increases prostate cancer oxygenation: a translational MRI study in murine xenografts and humans

Hypoxia has been associated with poor local tumour control and relapse in many cancer sites, including carcinoma of the prostate. This translational study tests whether breathing carbogen gas improves the oxygenation of human prostate carcinoma xenografts in mice and in human patients with prostate...

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Bibliographic Details
Published in:	British journal of cancer Vol. 100; no. 4; pp. 644 - 648
Main Authors:	Alonzi, R, Padhani, A R, Maxwell, R J, Taylor, N J, Stirling, J J, Wilson, J I, d′Arcy, J A, Collins, D J, Saunders, M I, Hoskin, P J
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 24.02.2009 Nature Publishing Group
Subjects:	Aged Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Carbon Dioxide - blood Carbon Dioxide - metabolism Cell Hypoxia Cell Line, Tumor Drug Resistance Epidemiology Human subjects Humans Hypoxia Magnetic Resonance Imaging Male Medical prognosis Medical research Medical sciences Mice Middle Aged Molecular Medicine Neoplasm Transplantation - diagnostic imaging Nephrology. Urinary tract diseases Oncology Oxygen - blood Oxygen - metabolism Oxygen Inhalation Therapy Prostate cancer Prostatic Neoplasms - diagnostic imaging Prostatic Neoplasms - metabolism Prostatic Neoplasms - therapy Radiation therapy Radiography Translational Therapeutics Transplantation, Heterologous Tumors Tumors of the urinary system Urinary tract. Prostate gland United Kingdom > UK hypoxia prostate cancer magnetic resonance imaging BOLD carbogen Prostate disease Transplantation Heterotransplantation Cancerology Surgery Graft Male genital diseases Human Oxygen Urinary system disease Rodentia Malignant tumor Nuclear magnetic resonance imaging Genetic translation Vertebrata Mammalia Treatment Mouse Animal Medical imagery Hypoxia Oxygenation Prostate cancer Cancer
ISSN:	0007-0920, 1532-1827, 1532-1827
Online Access:	Get full text
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