174G>C interleukin-6 gene polymorphism in Tunisian patients with coronary artery disease
A state of low-grade inflammation accompanies the pathogenesis of atherosclerotic events. Interleukin-6 (IL-6) is a pleotropic pro-inflammatory cytokine that modulates the development of acute coronary syndromes (ACSs), partly by destabilizing coronary atherosclerotic plaques. We have examined the c...
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| Vydáno v: | Annals of Saudi medicine Ročník 31; číslo 1; s. 40 - 44 |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Saudi Arabia
KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE
01.01.2011
Medknow Publications King Faisal Specialist Hospital and Research Centre |
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| ISSN: | 0256-4947, 0975-4466, 0975-4466 |
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| Abstract | A state of low-grade inflammation accompanies the pathogenesis of atherosclerotic events. Interleukin-6 (IL-6) is a pleotropic pro-inflammatory cytokine that modulates the development of acute coronary syndromes (ACSs), partly by destabilizing coronary atherosclerotic plaques. We have examined the contribution of the -174G>C IL-6 promoter variant on the risk of coronary artery disease (CAD) among Tunisians.
Study subjects included 418 CAD patients and 406 age- and sex-matched controls. IL-6 genotyping was done by PCR-restriction fragment length polymorphism.
The frequency of the -174C allele (mutant) was lower in Tunisians than in Europeans, and the distribution of -174 G>C genotypes was similar between CAD patients and control subjects. Moreover, compared to GG genotype carriers, -174C allele carriage did not increase the CAD relative risk (odds ratio and 95% confidence interval=1.09 and 0.80-1.49), which remained nonsignificant after adjusting for traditional risk factors for CAD (age, smoking, hypertension, diabetes and obesity).
The -174G>C IL-6 promoter variant is not associated with an increased risk of CAD among Tunisians. |
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| AbstractList | A state of low-grade inflammation accompanies the pathogenesis of atherosclerotic events. Interleukin-6 (IL-6) is a pleotropic pro-inflammatory cytokine that modulates the development of acute coronary syndromes (ACSs), partly by destabilizing coronary atherosclerotic plaques. We have examined the contribution of the -174G>C IL-6 promoter variant on the risk of coronary artery disease (CAD) among Tunisians.
Study subjects included 418 CAD patients and 406 age- and sex-matched controls. IL-6 genotyping was done by PCR-restriction fragment length polymorphism.
The frequency of the -174C allele (mutant) was lower in Tunisians than in Europeans, and the distribution of -174 G>C genotypes was similar between CAD patients and control subjects. Moreover, compared to GG genotype carriers, -174C allele carriage did not increase the CAD relative risk (odds ratio and 95% confidence interval=1.09 and 0.80-1.49), which remained nonsignificant after adjusting for traditional risk factors for CAD (age, smoking, hypertension, diabetes and obesity).
The -174G>C IL-6 promoter variant is not associated with an increased risk of CAD among Tunisians. Background and Objectives : A state of low-grade inflammation accompanies the pathogenesis of atherosclerotic events. Interleukin-6 (IL-6) is a pleotropic pro-inflammatory cytokine that modulates the development of acute coronary syndromes (ACSs), partly by destabilizing coronary atherosclerotic plaques. We have examined the contribution of the -174G>C IL-6 promoter variant on the risk of coronary artery disease (CAD) among Tunisians. Patients and Methods : Study subjects included 418 CAD patients and 406 age- and sex-matched controls. IL-6 genotyping was done by PCR-restriction fragment length polymorphism. Results : The frequency of the -174C allele (mutant) was lower in Tunisians than in Europeans, and the distribution of -174 G>C genotypes was similar between CAD patients and control subjects. Moreover, compared to GG genotype carriers, -174C allele carriage did not increase the CAD relative risk (odds ratio and 95% confidence interval=1.09 and 0.80-1.49), which remained nonsignificant after adjusting for traditional risk factors for CAD (age, smoking, hypertension, diabetes and obesity). Conclusion : The -174G>C IL-6 promoter variant is not associated with an increased risk of CAD among Tunisians. A state of low-grade inflammation accompanies the pathogenesis of atherosclerotic events. Interleukin-6 (IL-6) is a pleotropic pro-inflammatory cytokine that modulates the development of acute coronary syndromes (ACSs), partly by destabilizing coronary atherosclerotic plaques. We have examined the contribution of the -174G>C IL-6 promoter variant on the risk of coronary artery disease (CAD) among Tunisians.BACKGROUND AND OBJECTIVESA state of low-grade inflammation accompanies the pathogenesis of atherosclerotic events. Interleukin-6 (IL-6) is a pleotropic pro-inflammatory cytokine that modulates the development of acute coronary syndromes (ACSs), partly by destabilizing coronary atherosclerotic plaques. We have examined the contribution of the -174G>C IL-6 promoter variant on the risk of coronary artery disease (CAD) among Tunisians.Study subjects included 418 CAD patients and 406 age- and sex-matched controls. IL-6 genotyping was done by PCR-restriction fragment length polymorphism.PATIENTS AND METHODSStudy subjects included 418 CAD patients and 406 age- and sex-matched controls. IL-6 genotyping was done by PCR-restriction fragment length polymorphism.The frequency of the -174C allele (mutant) was lower in Tunisians than in Europeans, and the distribution of -174 G>C genotypes was similar between CAD patients and control subjects. Moreover, compared to GG genotype carriers, -174C allele carriage did not increase the CAD relative risk (odds ratio and 95% confidence interval=1.09 and 0.80-1.49), which remained nonsignificant after adjusting for traditional risk factors for CAD (age, smoking, hypertension, diabetes and obesity).RESULTSThe frequency of the -174C allele (mutant) was lower in Tunisians than in Europeans, and the distribution of -174 G>C genotypes was similar between CAD patients and control subjects. Moreover, compared to GG genotype carriers, -174C allele carriage did not increase the CAD relative risk (odds ratio and 95% confidence interval=1.09 and 0.80-1.49), which remained nonsignificant after adjusting for traditional risk factors for CAD (age, smoking, hypertension, diabetes and obesity).The -174G>C IL-6 promoter variant is not associated with an increased risk of CAD among Tunisians.CONCLUSIONThe -174G>C IL-6 promoter variant is not associated with an increased risk of CAD among Tunisians. |
| Author | Nsiri, Brahim Mahjoub, Touhami Khalifa, Sonia Ben Hadj Mediouni, Mounira Ghazouani, Lakhdar Added, Faouzi Khalfallah, Ali Ben Abboud, Nesrine |
| AuthorAffiliation | d Hospital Center of Jendoubad, Tunisia From the a Research Unit of Biology and Genetics of Cancer, Haematological and Autoimmune Diseases, Faculty of Pharmacy of Monastir, Monastir, Tunisia c Menzel Bourguiba Hospital Center, Bizerte, Tunisia b Fattouma Bourguiba Hospital Center, Monastir, Tunisia |
| AuthorAffiliation_xml | – name: b Fattouma Bourguiba Hospital Center, Monastir, Tunisia – name: d Hospital Center of Jendoubad, Tunisia – name: c Menzel Bourguiba Hospital Center, Bizerte, Tunisia – name: From the a Research Unit of Biology and Genetics of Cancer, Haematological and Autoimmune Diseases, Faculty of Pharmacy of Monastir, Monastir, Tunisia |
| Author_xml | – sequence: 1 givenname: Lakhdar surname: Ghazouani fullname: Ghazouani, Lakhdar organization: From the Research Unit of Biology and Genetics of Cancer, Haematological and Autoimmune Diseases, Faculty of Pharmacy of Monastir, Monastir, Tunisia – sequence: 2 givenname: Nesrine surname: Abboud fullname: Abboud, Nesrine organization: From the Research Unit of Biology and Genetics of Cancer, Haematological and Autoimmune Diseases, Faculty of Pharmacy of Monastir, Monastir, Tunisia – sequence: 3 givenname: Sonia Ben Hadj surname: Khalifa fullname: Khalifa, Sonia Ben Hadj organization: From the Research Unit of Biology and Genetics of Cancer, Haematological and Autoimmune Diseases, Faculty of Pharmacy of Monastir, Monastir, Tunisia – sequence: 4 givenname: Faouzi surname: Added fullname: Added, Faouzi organization: Fattouma Bourguiba Hospital Center, Monastir, Tunisia – sequence: 5 givenname: Ali Ben surname: Khalfallah fullname: Khalfallah, Ali Ben organization: Menzel Bourguiba Hospital Center, Bizerte, Tunisia – sequence: 6 givenname: Brahim surname: Nsiri fullname: Nsiri, Brahim organization: From the Research Unit of Biology and Genetics of Cancer, Haematological and Autoimmune Diseases, Faculty of Pharmacy of Monastir, Monastir, Tunisia – sequence: 7 givenname: Mounira surname: Mediouni fullname: Mediouni, Mounira organization: Hospital Center of Jendoubad, Tunisia – sequence: 8 givenname: Touhami surname: Mahjoub fullname: Mahjoub, Touhami organization: From the Research Unit of Biology and Genetics of Cancer, Haematological and Autoimmune Diseases, Faculty of Pharmacy of Monastir, Monastir, Tunisia |
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| Title | 174G>C interleukin-6 gene polymorphism in Tunisian patients with coronary artery disease |
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