Assessing the causal relationship between metabolic biomarkers and coronary artery disease by Mendelian randomization studies

The development of coronary artery disease (CAD) is significantly affected by impaired endocrine and metabolic status. Under this circumstance, improved prevention and treatment of CAD may result from knowing the connection between metabolites and CAD. This study aims to delve into the causal relati...

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Published in:Scientific reports Vol. 14; no. 1; pp. 19034 - 16
Main Authors: Yang, Kai, Li, Jixin, Hui, Xiaoshan, Wang, Wenru, Liu, Yongmei
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 16.08.2024
Nature Publishing Group
Nature Portfolio
Subjects:
631/114
631/208
692/163
692/4019
692/499
692/53
Asian People - genetics
Benzoic acid
Biomarker
Biomarkers
Biomarkers - blood
Blood
Cardiovascular disease
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - genetics
Coronary Artery Disease - metabolism
Coronary vessels
Female
Glycerol
Heart diseases
Heterogeneity
Humanities and Social Sciences
Humans
Interception
Male
Mendelian randomization
Mendelian Randomization Analysis
Metabolic pathways
Metabolism
Metabolites
Metabolomics - methods
multidisciplinary
Plasma metabolites
Pleiotropy
Prevention
Ratios
Risk assessment
Science
Science (multidisciplinary)
Sensitivity analysis
Spermidine
Vein & artery diseases
Plasma metabolites
Cardiovascular disease
Biomarker
Mendelian randomization
Risk assessment
ISSN:2045-2322, 2045-2322
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Abstract The development of coronary artery disease (CAD) is significantly affected by impaired endocrine and metabolic status. Under this circumstance, improved prevention and treatment of CAD may result from knowing the connection between metabolites and CAD. This study aims to delve into the causal relationship between human metabolic biomarkers and CAD by using two-sample Mendelian randomization (MR). Utilizing two-sample bidirectional MR analysis, we assessed the correlation between 1400 blood metabolites and CAD, and the metabolites data from the CLSA, encompassing 8299 participants. Metabolite analysis identified 1091 plasma metabolites and 309 ratios as instrumental variables. To evaluate the causal link between metabolites and CAD, we analyzed three datasets: ebi-a-GCST005195 (547,261 European & East Asian samples), bbj-a-159 (29,319 East Asian CAD cases & 183,134 East Asian controls), and ebi-a-GCST005194 (296,525 European & East Asian samples). To estimate causal links, we utilized the IVW method. To conduct sensitivity analysis, we used MR-Egger, Weighted Median, and MR-PRESSO. Additionally, we employed MR-Egger interception and Cochran’s Q statistic to assess potential heterogeneity and pleiotropy. What’s more, replication and reverse analyses were performed to verify the reliability of the results and the causal order between metabolites and disease. Furthermore, we conducted a pathway analysis to identify potential metabolic pathways. 59 blood metabolites and 27 metabolite ratios nominally associated with CAD (P < 0.05) were identified by IVW analysis method. A total of four known blood metabolites, namely beta-hydroxyisovaleroylcarnitine (OR 1.06, 95% CI 1.027–1.094, FDR 0.07), 1-palmitoyl-2-arachidonoyl (OR 1.07, 95% CI 1.029–1.110, FDR 0.09), 1-stearoyl-2- docosahexaenoyl (OR 1.07, 95% CI 1.034–1.113, FDR 0.07) and Linoleoyl-arachidonoyl-glycerol, (OR 1.07, 95% CI 1.036–1.105, FDR 0.05), and two metabolite ratios, namely spermidine to N-acetylputrescine ratio (OR 0.94, 95% CI 0.903–0.972, FDR 0.09) and benzoate to linoleoyl-arachidonoyl-glycerol ratio (OR 0.87, 95% CI 0.879–0.962, FDR 0.07), were confirmed as having a significant causal relationship with CAD, after correcting for the FDR method (p < 0. 1). A causal relationship was found to be established between beta -hydroxyisovalerylcarnitine and CAD with the validation in other two datasets. Moreover, multiple metabolic pathways were discovered to be associated with CAD. Our study supports the hypothesis that metabolites have an impact on CAD by demonstrating a causal relationship between human metabolites and CAD. This study is important for new strategies for the prevention and treatment of CAD.
AbstractList The development of coronary artery disease (CAD) is significantly affected by impaired endocrine and metabolic status. Under this circumstance, improved prevention and treatment of CAD may result from knowing the connection between metabolites and CAD. This study aims to delve into the causal relationship between human metabolic biomarkers and CAD by using two-sample Mendelian randomization (MR). Utilizing two-sample bidirectional MR analysis, we assessed the correlation between 1400 blood metabolites and CAD, and the metabolites data from the CLSA, encompassing 8299 participants. Metabolite analysis identified 1091 plasma metabolites and 309 ratios as instrumental variables. To evaluate the causal link between metabolites and CAD, we analyzed three datasets: ebi-a-GCST005195 (547,261 European & East Asian samples), bbj-a-159 (29,319 East Asian CAD cases & 183,134 East Asian controls), and ebi-a-GCST005194 (296,525 European & East Asian samples). To estimate causal links, we utilized the IVW method. To conduct sensitivity analysis, we used MR-Egger, Weighted Median, and MR-PRESSO. Additionally, we employed MR-Egger interception and Cochran’s Q statistic to assess potential heterogeneity and pleiotropy. What’s more, replication and reverse analyses were performed to verify the reliability of the results and the causal order between metabolites and disease. Furthermore, we conducted a pathway analysis to identify potential metabolic pathways. 59 blood metabolites and 27 metabolite ratios nominally associated with CAD (P < 0.05) were identified by IVW analysis method. A total of four known blood metabolites, namely beta-hydroxyisovaleroylcarnitine (OR 1.06, 95% CI 1.027–1.094, FDR 0.07), 1-palmitoyl-2-arachidonoyl (OR 1.07, 95% CI 1.029–1.110, FDR 0.09), 1-stearoyl-2- docosahexaenoyl (OR 1.07, 95% CI 1.034–1.113, FDR 0.07) and Linoleoyl-arachidonoyl-glycerol, (OR 1.07, 95% CI 1.036–1.105, FDR 0.05), and two metabolite ratios, namely spermidine to N-acetylputrescine ratio (OR 0.94, 95% CI 0.903–0.972, FDR 0.09) and benzoate to linoleoyl-arachidonoyl-glycerol ratio (OR 0.87, 95% CI 0.879–0.962, FDR 0.07), were confirmed as having a significant causal relationship with CAD, after correcting for the FDR method (p < 0. 1). A causal relationship was found to be established between beta -hydroxyisovalerylcarnitine and CAD with the validation in other two datasets. Moreover, multiple metabolic pathways were discovered to be associated with CAD. Our study supports the hypothesis that metabolites have an impact on CAD by demonstrating a causal relationship between human metabolites and CAD. This study is important for new strategies for the prevention and treatment of CAD.
Abstract The development of coronary artery disease (CAD) is significantly affected by impaired endocrine and metabolic status. Under this circumstance, improved prevention and treatment of CAD may result from knowing the connection between metabolites and CAD. This study aims to delve into the causal relationship between human metabolic biomarkers and CAD by using two-sample Mendelian randomization (MR). Utilizing two-sample bidirectional MR analysis, we assessed the correlation between 1400 blood metabolites and CAD, and the metabolites data from the CLSA, encompassing 8299 participants. Metabolite analysis identified 1091 plasma metabolites and 309 ratios as instrumental variables. To evaluate the causal link between metabolites and CAD, we analyzed three datasets: ebi-a-GCST005195 (547,261 European & East Asian samples), bbj-a-159 (29,319 East Asian CAD cases & 183,134 East Asian controls), and ebi-a-GCST005194 (296,525 European & East Asian samples). To estimate causal links, we utilized the IVW method. To conduct sensitivity analysis, we used MR-Egger, Weighted Median, and MR-PRESSO. Additionally, we employed MR-Egger interception and Cochran’s Q statistic to assess potential heterogeneity and pleiotropy. What’s more, replication and reverse analyses were performed to verify the reliability of the results and the causal order between metabolites and disease. Furthermore, we conducted a pathway analysis to identify potential metabolic pathways. 59 blood metabolites and 27 metabolite ratios nominally associated with CAD (P < 0.05) were identified by IVW analysis method. A total of four known blood metabolites, namely beta-hydroxyisovaleroylcarnitine (OR 1.06, 95% CI 1.027–1.094, FDR 0.07), 1-palmitoyl-2-arachidonoyl (OR 1.07, 95% CI 1.029–1.110, FDR 0.09), 1-stearoyl-2- docosahexaenoyl (OR 1.07, 95% CI 1.034–1.113, FDR 0.07) and Linoleoyl-arachidonoyl-glycerol, (OR 1.07, 95% CI 1.036–1.105, FDR 0.05), and two metabolite ratios, namely spermidine to N-acetylputrescine ratio (OR 0.94, 95% CI 0.903–0.972, FDR 0.09) and benzoate to linoleoyl-arachidonoyl-glycerol ratio (OR 0.87, 95% CI 0.879–0.962, FDR 0.07), were confirmed as having a significant causal relationship with CAD, after correcting for the FDR method (p < 0. 1). A causal relationship was found to be established between beta -hydroxyisovalerylcarnitine and CAD with the validation in other two datasets. Moreover, multiple metabolic pathways were discovered to be associated with CAD. Our study supports the hypothesis that metabolites have an impact on CAD by demonstrating a causal relationship between human metabolites and CAD. This study is important for new strategies for the prevention and treatment of CAD.
The development of coronary artery disease (CAD) is significantly affected by impaired endocrine and metabolic status. Under this circumstance, improved prevention and treatment of CAD may result from knowing the connection between metabolites and CAD. This study aims to delve into the causal relationship between human metabolic biomarkers and CAD by using two-sample Mendelian randomization (MR). Utilizing two-sample bidirectional MR analysis, we assessed the correlation between 1400 blood metabolites and CAD, and the metabolites data from the CLSA, encompassing 8299 participants. Metabolite analysis identified 1091 plasma metabolites and 309 ratios as instrumental variables. To evaluate the causal link between metabolites and CAD, we analyzed three datasets: ebi-a-GCST005195 (547,261 European & East Asian samples), bbj-a-159 (29,319 East Asian CAD cases & 183,134 East Asian controls), and ebi-a-GCST005194 (296,525 European & East Asian samples). To estimate causal links, we utilized the IVW method. To conduct sensitivity analysis, we used MR-Egger, Weighted Median, and MR-PRESSO. Additionally, we employed MR-Egger interception and Cochran's Q statistic to assess potential heterogeneity and pleiotropy. What's more, replication and reverse analyses were performed to verify the reliability of the results and the causal order between metabolites and disease. Furthermore, we conducted a pathway analysis to identify potential metabolic pathways. 59 blood metabolites and 27 metabolite ratios nominally associated with CAD (P < 0.05) were identified by IVW analysis method. A total of four known blood metabolites, namely beta-hydroxyisovaleroylcarnitine (OR 1.06, 95% CI 1.027-1.094, FDR 0.07), 1-palmitoyl-2-arachidonoyl (OR 1.07, 95% CI 1.029-1.110, FDR 0.09), 1-stearoyl-2- docosahexaenoyl (OR 1.07, 95% CI 1.034-1.113, FDR 0.07) and Linoleoyl-arachidonoyl-glycerol, (OR 1.07, 95% CI 1.036-1.105, FDR 0.05), and two metabolite ratios, namely spermidine to N-acetylputrescine ratio (OR 0.94, 95% CI 0.903-0.972, FDR 0.09) and benzoate to linoleoyl-arachidonoyl-glycerol ratio (OR 0.87, 95% CI 0.879-0.962, FDR 0.07), were confirmed as having a significant causal relationship with CAD, after correcting for the FDR method (p < 0. 1). A causal relationship was found to be established between beta -hydroxyisovalerylcarnitine and CAD with the validation in other two datasets. Moreover, multiple metabolic pathways were discovered to be associated with CAD. Our study supports the hypothesis that metabolites have an impact on CAD by demonstrating a causal relationship between human metabolites and CAD. This study is important for new strategies for the prevention and treatment of CAD.The development of coronary artery disease (CAD) is significantly affected by impaired endocrine and metabolic status. Under this circumstance, improved prevention and treatment of CAD may result from knowing the connection between metabolites and CAD. This study aims to delve into the causal relationship between human metabolic biomarkers and CAD by using two-sample Mendelian randomization (MR). Utilizing two-sample bidirectional MR analysis, we assessed the correlation between 1400 blood metabolites and CAD, and the metabolites data from the CLSA, encompassing 8299 participants. Metabolite analysis identified 1091 plasma metabolites and 309 ratios as instrumental variables. To evaluate the causal link between metabolites and CAD, we analyzed three datasets: ebi-a-GCST005195 (547,261 European & East Asian samples), bbj-a-159 (29,319 East Asian CAD cases & 183,134 East Asian controls), and ebi-a-GCST005194 (296,525 European & East Asian samples). To estimate causal links, we utilized the IVW method. To conduct sensitivity analysis, we used MR-Egger, Weighted Median, and MR-PRESSO. Additionally, we employed MR-Egger interception and Cochran's Q statistic to assess potential heterogeneity and pleiotropy. What's more, replication and reverse analyses were performed to verify the reliability of the results and the causal order between metabolites and disease. Furthermore, we conducted a pathway analysis to identify potential metabolic pathways. 59 blood metabolites and 27 metabolite ratios nominally associated with CAD (P < 0.05) were identified by IVW analysis method. A total of four known blood metabolites, namely beta-hydroxyisovaleroylcarnitine (OR 1.06, 95% CI 1.027-1.094, FDR 0.07), 1-palmitoyl-2-arachidonoyl (OR 1.07, 95% CI 1.029-1.110, FDR 0.09), 1-stearoyl-2- docosahexaenoyl (OR 1.07, 95% CI 1.034-1.113, FDR 0.07) and Linoleoyl-arachidonoyl-glycerol, (OR 1.07, 95% CI 1.036-1.105, FDR 0.05), and two metabolite ratios, namely spermidine to N-acetylputrescine ratio (OR 0.94, 95% CI 0.903-0.972, FDR 0.09) and benzoate to linoleoyl-arachidonoyl-glycerol ratio (OR 0.87, 95% CI 0.879-0.962, FDR 0.07), were confirmed as having a significant causal relationship with CAD, after correcting for the FDR method (p < 0. 1). A causal relationship was found to be established between beta -hydroxyisovalerylcarnitine and CAD with the validation in other two datasets. Moreover, multiple metabolic pathways were discovered to be associated with CAD. Our study supports the hypothesis that metabolites have an impact on CAD by demonstrating a causal relationship between human metabolites and CAD. This study is important for new strategies for the prevention and treatment of CAD.
ArticleNumber 19034
Author Li, Jixin
Liu, Yongmei
Wang, Wenru
Hui, Xiaoshan
Yang, Kai
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  givenname: Yongmei
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  fullname: Liu, Yongmei
  email: lymdoctor@163.com
  organization: Guang’anmen Hospital, China Academy of Chinese Medical Sciences
BackLink https://www.ncbi.nlm.nih.gov/pubmed/39152174$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1155_jnme_2292774
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crossref_primary_10_1093_postmj_qgaf145
crossref_primary_10_1097_MD_0000000000040824
crossref_primary_10_3390_ijms26083572
Cites_doi 10.1016/j.jhepr.2024.101037
10.1093/nar/gky310
10.2337/db19-0153
10.1093/ije/dyx102
10.1177/0003319717690993
10.1007/s10654-017-0255-x
10.1016/0735-1097(94)90433-2
10.1161/CIRCRESAHA.117.312086
10.3389/fendo.2023.1271942
10.1016/j.clnu.2020.09.035
10.1002/jmv.28880
10.3389/fcvm.2022.965899
10.1161/CIRCGEN.121.003501
10.1038/4027
10.1016/j.atherosclerosis.2020.01.015
10.1186/s13073-022-01067-1
10.1016/j.atherosclerosis.2020.09.029
10.1007/s12350-018-01506-w
10.3389/fendo.2023.1291445
10.1016/0009-8981(95)06126-2
10.1080/10408369991239231
10.1186/s12917-016-0736-2
10.1016/j.amjmed.2022.08.012
10.3389/fcvm.2021.789458
10.1093/ije/dyv080
10.1002/gepi.22295
10.1016/j.ejim.2017.03.019
10.1038/s41588-022-01270-1
10.1016/j.bcp.2020.114065
10.2174/1568026623666221213085917
10.3390/nu15224787
10.1038/nrm.2016.25
10.1186/s12967-022-03799-5
10.1016/j.tcm.2015.03.010
10.1016/j.yjmcc.2022.05.013
10.3390/nu15071580
10.1093/ije/dyx034
10.1016/j.jacc.2020.11.010
10.1161/ATVBAHA.123.319674
10.1093/eurheartj/ehaa209
10.1186/s12916-022-02688-4
10.1161/JAHA.119.012486
10.3389/fendo.2023.1277153
10.1016/j.nut.2014.08.011
10.3390/nu15041016
10.18632/aging.102815
10.3390/nu15163593
10.1007/BF02436004
10.3389/fendo.2021.794437
10.1001/jamacardio.2017.1239
10.1038/s41569-021-00638-w
10.1002/jcp.28350
10.3389/fimmu.2022.829425
10.1002/hep.32534
10.1016/j.preteyeres.2018.11.002
10.3389/fimmu.2024.1374938
10.1016/j.jcmg.2021.06.013
10.1146/annurev.genet.34.1.233
10.1016/j.yjmcc.2018.01.013
10.1186/s12967-022-03691-2
10.1093/eurheartj/ehz859
10.1186/s12967-023-04165-9
10.1111/apt.15446
10.1016/S0021-9150(96)06044-3
10.1016/j.clnu.2005.07.003
10.1016/j.jaut.2005.03.001
10.3390/nu13010021
10.1016/j.bbrc.2011.08.073
10.3390/ijms25147706
10.1016/j.mvr.2014.08.003
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Issue 1
Keywords Plasma metabolites
Cardiovascular disease
Biomarker
Mendelian randomization
Risk assessment
Language English
License 2024. The Author(s).
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References Ma, Li, An, Guo, Liu (CR13) 2023
Santos, Shapiro (CR37) 2021; 14
Xiao (CR11) 2022; 20
Akashi, Higashi, Masuda, Komori, Furuse (CR66) 2011; 413
Cheng (CR15) 2023; 15
Xu (CR23) 2023; 15
Xu (CR45) 2016; 12
Huang (CR27) 2024; 6
Kolwicz (CR52) 2021; 8
van der Harst, Verweij (CR26) 2018; 122
Wang (CR68) 2020; 178
Liang (CR18) 2023; 14
Xiong, Jiang, Li (CR44) 2022; 9
Wang (CR6) 2022; 14
Williams (CR51) 2019; 26
Ren, Simons, Wesselius, Stehouwer, Brouwers (CR5) 2023; 77
Chen (CR50) 2022; 135
Wang (CR28) 2024; 25
Burgess, Thompson (CR34) 2017; 32
Chong (CR35) 2018; 46
Gagnon (CR22) 2023; 21
Tsigkas (CR48) 2017; 68
Hung (CR53) 2020; 13
Clarke (CR36) 2022; 15
Liu (CR32) 2024; 15
Johnson, Ivanisevic, Siuzdak (CR9) 2016; 17
Li (CR21) 2020; 41
Chen (CR33) 2023; 95
Yin (CR62) 2005; 24
Wang (CR54) 2017; 2
Zhu (CR58) 2022; 13
Jia (CR20) 2019; 68
Karki, Birukov (CR56) 2021; 12
De La Barrera, Manousaki (CR16) 2023; 15
Breslow (CR40) 2000; 34
Langman, Cole (CR39) 1999; 36
Gu (CR12) 2023; 21
Malakar (CR3) 2019; 234
Doestzada (CR19) 2022; 20
Roth (CR1) 2020; 76
Papageorgiou (CR59) 2023; 23
Luo (CR69) 2022; 170
Bell, Gibson, Harshfield, Markus (CR8) 2020; 313
Yavorska, Burgess (CR25) 2017; 46
Kang (CR17) 2023; 14
Timmis (CR2) 2020; 41
Wu, Shen, Morris, Patnaik, Peter (CR55) 2005; 24
Rungoe, Nyboe Andersen, Jess (CR46) 2015; 25
Das (CR64) 2015; 31
Li, Lu, Qi, Chen, Li (CR14) 2023; 15
Chen (CR24) 2023; 55
Choi (CR47) 2019; 50
Post (CR41) 2021; 40
Bowden, Davey Smith, Burgess (CR30) 2015; 44
Adams (CR63) 1997; 129
Laíns (CR10) 2019; 69
Karvonen (CR65) 1998; 4
Guo (CR70) 2018; 116
Pu (CR67) 2020; 296
Röschinger (CR43) 1995; 240
Wang (CR61) 1994; 23
Klarin, Natarajan (CR4) 2022; 19
Caliskan (CR49) 2015; 97
Liu (CR7) 2020; 12
Appleton, Palmer, Smith, Stephens, Major (CR57) 2023; 43
Rodionov (CR60) 2019; 8
Girelli, Piubelli, Martinelli, Corrocher, Olivieri (CR38) 2017; 41
Slob, Burgess (CR29) 2020; 44
van Hove, Rutledge, Nada, Kahler, Millington (CR42) 1995; 18
Hartwig, Davey Smith, Bowden (CR31) 2017; 46
J Chong (69879_CR35) 2018; 46
H-M Liu (69879_CR7) 2020; 12
P-L Hung (69879_CR53) 2020; 13
LJ Langman (69879_CR39) 1999; 36
YJ Choi (69879_CR47) 2019; 50
BD Appleton (69879_CR57) 2023; 43
UN Das (69879_CR64) 2015; 31
M Akashi (69879_CR66) 2011; 413
T Luo (69879_CR69) 2022; 170
Z Ren (69879_CR5) 2023; 77
K Guo (69879_CR70) 2018; 116
Q Ma (69879_CR13) 2023
P van der Harst (69879_CR26) 2018; 122
H Liang (69879_CR18) 2023; 14
FP Hartwig (69879_CR31) 2017; 46
D Klarin (69879_CR4) 2022; 19
H Cheng (69879_CR15) 2023; 15
S Wang (69879_CR28) 2024; 25
H Chen (69879_CR33) 2023; 95
A Post (69879_CR41) 2021; 40
J Jia (69879_CR20) 2019; 68
SL Clarke (69879_CR36) 2022; 15
J Kang (69879_CR17) 2023; 14
B De La Barrera (69879_CR16) 2023; 15
M Doestzada (69879_CR19) 2022; 20
W-H Yin (69879_CR62) 2005; 24
E Gagnon (69879_CR22) 2023; 21
JL Breslow (69879_CR40) 2000; 34
CH Johnson (69879_CR9) 2016; 17
MK Karvonen (69879_CR65) 1998; 4
OO Yavorska (69879_CR25) 2017; 46
D Girelli (69879_CR38) 2017; 41
J Xu (69879_CR45) 2016; 12
GA Roth (69879_CR1) 2020; 76
JL van Hove (69879_CR42) 1995; 18
I Laíns (69879_CR10) 2019; 69
X Li (69879_CR14) 2023; 15
MR Adams (69879_CR63) 1997; 129
EAW Slob (69879_CR29) 2020; 44
AK Malakar (69879_CR3) 2019; 234
G Xiao (69879_CR11) 2022; 20
Y Chen (69879_CR24) 2023; 55
SC Kolwicz (69879_CR52) 2021; 8
Q Liu (69879_CR32) 2024; 15
N Papageorgiou (69879_CR59) 2023; 23
X Pu (69879_CR67) 2020; 296
S Bell (69879_CR8) 2020; 313
W Huang (69879_CR27) 2024; 6
S Burgess (69879_CR34) 2017; 32
B Chen (69879_CR50) 2022; 135
C Rungoe (69879_CR46) 2015; 25
H Xu (69879_CR23) 2023; 15
RD Santos (69879_CR37) 2021; 14
K Wang (69879_CR6) 2022; 14
A Timmis (69879_CR2) 2020; 41
J Li (69879_CR21) 2020; 41
W Röschinger (69879_CR43) 1995; 240
RN Rodionov (69879_CR60) 2019; 8
Y Xiong (69879_CR44) 2022; 9
Z Caliskan (69879_CR49) 2015; 97
R Wu (69879_CR55) 2005; 24
KA Williams (69879_CR51) 2019; 26
G Tsigkas (69879_CR48) 2017; 68
P Karki (69879_CR56) 2021; 12
H Wang (69879_CR54) 2017; 2
J Bowden (69879_CR30) 2015; 44
Q Zhu (69879_CR58) 2022; 13
Y Gu (69879_CR12) 2023; 21
BY Wang (69879_CR61) 1994; 23
J Wang (69879_CR68) 2020; 178
References_xml – volume: 6
  start-page: 101037
  year: 2024
  ident: CR27
  article-title: Investigating shared genetic architecture between inflammatory bowel diseases and primary biliary cholangitis
  publication-title: JHEP Rep.
  doi: 10.1016/j.jhepr.2024.101037
– volume: 46
  start-page: W486
  year: 2018
  end-page: W494
  ident: CR35
  article-title: MetaboAnalyst 4.0: Towards more transparent and integrative metabolomics analysis
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky310
– volume: 68
  start-page: 1747
  year: 2019
  end-page: 1755
  ident: CR20
  article-title: Assessment of causal direction between gut microbiota-dependent metabolites and cardiometabolic health: A bidirectional Mendelian randomization analysis
  publication-title: Diabetes
  doi: 10.2337/db19-0153
– volume: 46
  start-page: 1985
  year: 2017
  end-page: 1998
  ident: CR31
  article-title: Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/dyx102
– volume: 68
  start-page: 845
  year: 2017
  end-page: 849
  ident: CR48
  article-title: Inflammatory bowel disease: A potential risk factor for coronary artery disease
  publication-title: Angiology
  doi: 10.1177/0003319717690993
– volume: 32
  start-page: 377
  year: 2017
  end-page: 389
  ident: CR34
  article-title: Interpreting findings from Mendelian randomization using the MR-Egger method
  publication-title: Eur. J. Epidemiol.
  doi: 10.1007/s10654-017-0255-x
– volume: 23
  start-page: 452
  year: 1994
  end-page: 458
  ident: CR61
  article-title: Dietary arginine prevents atherogenesis in the coronary artery of the hypercholesterolemic rabbit
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/0735-1097(94)90433-2
– volume: 122
  start-page: 433
  year: 2018
  end-page: 443
  ident: CR26
  article-title: Identification of 64 novel genetic loci provides an expanded view on the genetic architecture of coronary artery disease
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.117.312086
– volume: 14
  start-page: 1271942
  year: 2023
  ident: CR17
  article-title: The association of lipid metabolism with bone metabolism and the role of human traits: A Mendelian randomization study
  publication-title: Front. Endocrinol. (Lausanne)
  doi: 10.3389/fendo.2023.1271942
– volume: 40
  start-page: 2109
  year: 2021
  end-page: 2120
  ident: CR41
  article-title: Urinary 3-hydroxyisovaleryl carnitine excretion, protein energy malnutrition and risk of all-cause mortality in kidney transplant recipients: Results from the TransplantLines cohort studies
  publication-title: Clin. Nutr.
  doi: 10.1016/j.clnu.2020.09.035
– volume: 95
  start-page: e28880
  year: 2023
  ident: CR33
  article-title: The causal role of gut microbiota in susceptibility and severity of COVID-19: A bidirectional Mendelian randomization study
  publication-title: J. Med. Virol.
  doi: 10.1002/jmv.28880
– volume: 9
  start-page: 965899
  year: 2022
  ident: CR44
  article-title: Aberrant branched-chain amino acid catabolism in cardiovascular diseases
  publication-title: Front. Cardiovasc. Med.
  doi: 10.3389/fcvm.2022.965899
– volume: 15
  start-page: e003501
  year: 2022
  ident: CR36
  article-title: Coronary artery disease risk of familial hypercholesterolemia genetic variants independent of clinically observed longitudinal cholesterol exposure
  publication-title: Circ. Genom. Precis. Med.
  doi: 10.1161/CIRCGEN.121.003501
– volume: 4
  start-page: 1434
  year: 1998
  end-page: 1437
  ident: CR65
  article-title: Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels
  publication-title: Nat. Med.
  doi: 10.1038/4027
– volume: 296
  start-page: 11
  year: 2020
  end-page: 17
  ident: CR67
  article-title: Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2020.01.015
– volume: 14
  start-page: 63
  year: 2022
  ident: CR6
  article-title: Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations
  publication-title: Genome Med.
  doi: 10.1186/s13073-022-01067-1
– volume: 313
  start-page: 111
  year: 2020
  end-page: 117
  ident: CR8
  article-title: Is periodontitis a risk factor for ischaemic stroke, coronary artery disease and subclinical atherosclerosis? A Mendelian randomization study
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2020.09.029
– volume: 26
  start-page: 86
  year: 2019
  end-page: 91
  ident: CR51
  article-title: Nutrition, risk factors, prevention, and imaging: The 2018 Mario Verani Lecture
  publication-title: J. Nucl. Cardiol.
  doi: 10.1007/s12350-018-01506-w
– year: 2023
  ident: CR13
  article-title: Assessment of causal association between differentiated thyroid cancer and disordered serum lipid profile: A Mendelian randomization study
  publication-title: Front. Endocrinol.
  doi: 10.3389/fendo.2023.1291445
– volume: 240
  start-page: 35
  year: 1995
  end-page: 51
  ident: CR43
  article-title: 3-Hydroxyisovalerylcarnitine in patients with deficiency of 3-methylcrotonyl CoA carboxylase
  publication-title: Clin. Chim. Acta
  doi: 10.1016/0009-8981(95)06126-2
– volume: 36
  start-page: 365
  year: 1999
  end-page: 406
  ident: CR39
  article-title: Homocysteine
  publication-title: Crit. Rev. Clin. Lab. Sci.
  doi: 10.1080/10408369991239231
– volume: 12
  start-page: 114
  year: 2016
  ident: CR45
  article-title: Does canine inflammatory bowel disease influence gut microbial profile and host metabolism?
  publication-title: BMC Vet. Res.
  doi: 10.1186/s12917-016-0736-2
– volume: 135
  start-page: 1453
  year: 2022
  end-page: 1460
  ident: CR50
  article-title: Inflammatory bowel disease and cardiovascular diseases
  publication-title: Am. J. Med.
  doi: 10.1016/j.amjmed.2022.08.012
– volume: 8
  start-page: 789458
  year: 2021
  ident: CR52
  article-title: Ketone body metabolism in the ischemic heart
  publication-title: Front. Cardiovasc. Med.
  doi: 10.3389/fcvm.2021.789458
– volume: 44
  start-page: 512
  year: 2015
  end-page: 525
  ident: CR30
  article-title: Mendelian randomization with invalid instruments: Effect estimation and bias detection through Egger regression
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/dyv080
– volume: 44
  start-page: 313
  year: 2020
  end-page: 329
  ident: CR29
  article-title: A comparison of robust Mendelian randomization methods using summary data
  publication-title: Genet. Epidemiol.
  doi: 10.1002/gepi.22295
– volume: 41
  start-page: 10
  year: 2017
  end-page: 17
  ident: CR38
  article-title: A decade of progress on the genetic basis of coronary artery disease. Practical insights for the internist
  publication-title: Eur. J. Intern. Med.
  doi: 10.1016/j.ejim.2017.03.019
– volume: 55
  start-page: 44
  year: 2023
  end-page: 53
  ident: CR24
  article-title: Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-022-01270-1
– volume: 178
  start-page: 114065
  year: 2020
  ident: CR68
  article-title: Proline improves cardiac remodeling following myocardial infarction and attenuates cardiomyocyte apoptosis via redox regulation
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2020.114065
– volume: 23
  start-page: 470
  year: 2023
  end-page: 480
  ident: CR59
  article-title: Asymmetric dimethylarginine as a biomarker in coronary artery disease
  publication-title: Curr. Top. Med. Chem.
  doi: 10.2174/1568026623666221213085917
– volume: 15
  start-page: 4787
  year: 2023
  ident: CR14
  article-title: The role of polyunsaturated fatty acids in osteoarthritis: Insights from a Mendelian randomization study
  publication-title: Nutrients
  doi: 10.3390/nu15224787
– volume: 17
  start-page: 451
  year: 2016
  end-page: 459
  ident: CR9
  article-title: Metabolomics: Beyond biomarkers and towards mechanisms
  publication-title: Nat. Rev. Mol. Cell. Biol.
  doi: 10.1038/nrm.2016.25
– volume: 21
  start-page: 60
  year: 2023
  ident: CR22
  article-title: Impact of the gut microbiota and associated metabolites on cardiometabolic traits, chronic diseases and human longevity: A Mendelian randomization study
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-022-03799-5
– volume: 25
  start-page: 699
  year: 2015
  end-page: 704
  ident: CR46
  article-title: Inflammatory bowel disease and risk of coronary heart disease
  publication-title: Trends Cardiovasc. Med.
  doi: 10.1016/j.tcm.2015.03.010
– volume: 170
  start-page: 60
  year: 2022
  end-page: 74
  ident: CR69
  article-title: Deficiency of proline/serine-rich coiled-coil protein 1 (PSRC1) accelerates trimethylamine N-oxide-induced atherosclerosis in ApoE-/- mice
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2022.05.013
– volume: 15
  start-page: 1580
  year: 2023
  ident: CR23
  article-title: Association of circulating branched-chain amino acids with cardiovascular diseases: A Mendelian randomization study
  publication-title: Nutrients
  doi: 10.3390/nu15071580
– volume: 46
  start-page: 1734
  year: 2017
  end-page: 1739
  ident: CR25
  article-title: MendelianRandomization: An R package for performing Mendelian randomization analyses using summarized data
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/dyx034
– volume: 76
  start-page: 2982
  year: 2020
  end-page: 3021
  ident: CR1
  article-title: Global burden of cardiovascular diseases and risk factors, 1990–2019: Update from the GBD 2019 study
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2020.11.010
– volume: 43
  start-page: 2119
  year: 2023
  end-page: 2132
  ident: CR57
  article-title: Oxidized phospholipid oxPAPC alters regulatory T-cell differentiation and decreases their protective function in atherosclerosis in mice
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.123.319674
– volume: 41
  start-page: 2645
  year: 2020
  end-page: 2656
  ident: CR21
  article-title: The Mediterranean diet, plasma metabolome, and cardiovascular disease risk
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehaa209
– volume: 20
  start-page: 485
  year: 2022
  ident: CR19
  article-title: Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: An association and Mendelian randomization study
  publication-title: BMC Med.
  doi: 10.1186/s12916-022-02688-4
– volume: 8
  start-page: e012486
  year: 2019
  ident: CR60
  article-title: Homoarginine supplementation prevents left ventricular dilatation and preserves systolic function in a model of coronary artery disease
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.119.012486
– volume: 14
  start-page: 1277153
  year: 2023
  ident: CR18
  article-title: Causal relationship between linoleic acid and type 2 diabetes and glycemic traits: A bidirectional Mendelian randomization study
  publication-title: Front. Endocrinol. (Lausanne)
  doi: 10.3389/fendo.2023.1277153
– volume: 31
  start-page: 283
  year: 2015
  end-page: 291
  ident: CR64
  article-title: Nutritional factors in the prevention and management of coronary artery disease and heart failure
  publication-title: Nutrition
  doi: 10.1016/j.nut.2014.08.011
– volume: 15
  start-page: 1016
  year: 2023
  ident: CR16
  article-title: Serum 25-hydroxyvitamin D levels and youth-onset type 2 diabetes: A two-sample Mendelian randomization study
  publication-title: Nutrients
  doi: 10.3390/nu15041016
– volume: 12
  start-page: 3340
  year: 2020
  end-page: 3353
  ident: CR7
  article-title: Sarcopenia-related traits and coronary artery disease: A bi-directional Mendelian randomization study
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.102815
– volume: 15
  start-page: 3593
  year: 2023
  ident: CR15
  article-title: Association of 25-hydroxyvitamin D with preterm birth and premature rupture of membranes: A Mendelian randomization study
  publication-title: Nutrients
  doi: 10.3390/nu15163593
– volume: 18
  start-page: 592
  year: 1995
  end-page: 601
  ident: CR42
  article-title: 3-Hydroxyisovalerylcarnitine in 3-methylcrotonyl-CoA carboxylase deficiency
  publication-title: J. Inherit. Metab. Dis.
  doi: 10.1007/BF02436004
– volume: 12
  start-page: 794437
  year: 2021
  ident: CR56
  article-title: Oxidized phospholipids in control of endothelial barrier function: Mechanisms and implication in lung injury
  publication-title: Front. Endocrinol. (Lausanne)
  doi: 10.3389/fendo.2021.794437
– volume: 2
  start-page: 896
  year: 2017
  end-page: 901
  ident: CR54
  article-title: Sildenafil treatment in heart failure with preserved ejection fraction: Targeted metabolomic profiling in the RELAX trial
  publication-title: JAMA Cardiol.
  doi: 10.1001/jamacardio.2017.1239
– volume: 19
  start-page: 291
  year: 2022
  end-page: 301
  ident: CR4
  article-title: Clinical utility of polygenic risk scores for coronary artery disease
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/s41569-021-00638-w
– volume: 234
  start-page: 16812
  year: 2019
  end-page: 16823
  ident: CR3
  article-title: A review on coronary artery disease, its risk factors, and therapeutics
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.28350
– volume: 13
  start-page: 829425
  year: 2022
  ident: CR58
  article-title: Comprehensive metabolic profiling of inflammation indicated key roles of glycerophospholipid and arginine metabolism in coronary artery disease
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2022.829425
– volume: 77
  start-page: 230
  year: 2023
  end-page: 238
  ident: CR5
  article-title: Relationship between NAFLD and coronary artery disease: A Mendelian randomization study
  publication-title: Hepatology
  doi: 10.1002/hep.32534
– volume: 69
  start-page: 57
  year: 2019
  end-page: 79
  ident: CR10
  article-title: Metabolomics in the study of retinal health and disease
  publication-title: Prog. Retin. Eye Res.
  doi: 10.1016/j.preteyeres.2018.11.002
– volume: 15
  start-page: 1374938
  year: 2024
  ident: CR32
  article-title: Exploring risk factors for autoimmune diseases complicated by non-hodgkin lymphoma through regulatory T cell immune-related traits: A Mendelian randomization study
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2024.1374938
– volume: 14
  start-page: 2425
  year: 2021
  end-page: 2428
  ident: CR37
  article-title: Coronary artery calcification and risk stratification in familial hypercholesterolemia: Moving forward but not there yet
  publication-title: JACC Cardiovasc. Imaging
  doi: 10.1016/j.jcmg.2021.06.013
– volume: 34
  start-page: 233
  year: 2000
  end-page: 254
  ident: CR40
  article-title: Genetics of lipoprotein abnormalities associated with coronary artery disease susceptibility
  publication-title: Annu. Rev. Genet.
  doi: 10.1146/annurev.genet.34.1.233
– volume: 116
  start-page: 69
  year: 2018
  end-page: 80
  ident: CR70
  article-title: PSRC1 overexpression attenuates atherosclerosis progression in apoE-/- mice by modulating cholesterol transportation and inflammation
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2018.01.013
– volume: 20
  start-page: 475
  year: 2022
  ident: CR11
  article-title: Causality of genetically determined metabolites on anxiety disorders: A two-sample Mendelian randomization study
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-022-03691-2
– volume: 41
  start-page: 12
  year: 2020
  end-page: 85
  ident: CR2
  article-title: European society of cardiology: Cardiovascular disease statistics 2019
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehz859
– volume: 21
  start-page: 357
  year: 2023
  ident: CR12
  article-title: Causality of genetically determined metabolites and metabolic pathways on osteoarthritis: A two-sample mendelian randomization study
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-023-04165-9
– volume: 50
  start-page: 769
  year: 2019
  end-page: 779
  ident: CR47
  article-title: Patients with inflammatory bowel disease have an increased risk of myocardial infarction: A nationwide study
  publication-title: Aliment. Pharmacol. Ther.
  doi: 10.1111/apt.15446
– volume: 129
  start-page: 261
  year: 1997
  end-page: 269
  ident: CR63
  article-title: Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease
  publication-title: Atherosclerosis
  doi: 10.1016/S0021-9150(96)06044-3
– volume: 24
  start-page: 988
  year: 2005
  end-page: 997
  ident: CR62
  article-title: L-arginine improves endothelial function and reduces LDL oxidation in patients with stable coronary artery disease
  publication-title: Clin. Nutr.
  doi: 10.1016/j.clnu.2005.07.003
– volume: 24
  start-page: 353
  year: 2005
  end-page: 360
  ident: CR55
  article-title: Elevated autoantibodies against oxidized palmitoyl arachidonoyl phosphocholine in patients with hypertension and myocardial infarction
  publication-title: J. Autoimmun.
  doi: 10.1016/j.jaut.2005.03.001
– volume: 13
  start-page: 21
  year: 2020
  ident: CR53
  article-title: An examination of serum acylcarnitine and amino acid profiles at different time point of ketogenic diet therapy and their association of ketogenic diet effectiveness
  publication-title: Nutrients
  doi: 10.3390/nu13010021
– volume: 413
  start-page: 224
  year: 2011
  end-page: 229
  ident: CR66
  article-title: A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2011.08.073
– volume: 25
  start-page: 7706
  year: 2024
  ident: CR28
  article-title: Genetically Predicted peripheral immune cells mediate the effect of gut microbiota on influenza susceptibility
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms25147706
– volume: 97
  start-page: 25
  year: 2015
  end-page: 30
  ident: CR49
  article-title: Impaired coronary microvascular and left ventricular diastolic function in patients with inflammatory bowel disease
  publication-title: Microvasc. Res.
  doi: 10.1016/j.mvr.2014.08.003
– volume: 44
  start-page: 512
  year: 2015
  ident: 69879_CR30
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/dyv080
– volume: 46
  start-page: 1734
  year: 2017
  ident: 69879_CR25
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/dyx034
– volume: 116
  start-page: 69
  year: 2018
  ident: 69879_CR70
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2018.01.013
– volume: 68
  start-page: 845
  year: 2017
  ident: 69879_CR48
  publication-title: Angiology
  doi: 10.1177/0003319717690993
– volume: 9
  start-page: 965899
  year: 2022
  ident: 69879_CR44
  publication-title: Front. Cardiovasc. Med.
  doi: 10.3389/fcvm.2022.965899
– volume: 68
  start-page: 1747
  year: 2019
  ident: 69879_CR20
  publication-title: Diabetes
  doi: 10.2337/db19-0153
– volume: 20
  start-page: 485
  year: 2022
  ident: 69879_CR19
  publication-title: BMC Med.
  doi: 10.1186/s12916-022-02688-4
– volume: 8
  start-page: e012486
  year: 2019
  ident: 69879_CR60
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.119.012486
– volume: 46
  start-page: W486
  year: 2018
  ident: 69879_CR35
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky310
– volume: 95
  start-page: e28880
  year: 2023
  ident: 69879_CR33
  publication-title: J. Med. Virol.
  doi: 10.1002/jmv.28880
– volume: 413
  start-page: 224
  year: 2011
  ident: 69879_CR66
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2011.08.073
– volume: 40
  start-page: 2109
  year: 2021
  ident: 69879_CR41
  publication-title: Clin. Nutr.
  doi: 10.1016/j.clnu.2020.09.035
– volume: 21
  start-page: 357
  year: 2023
  ident: 69879_CR12
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-023-04165-9
– volume: 21
  start-page: 60
  year: 2023
  ident: 69879_CR22
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-022-03799-5
– volume: 240
  start-page: 35
  year: 1995
  ident: 69879_CR43
  publication-title: Clin. Chim. Acta
  doi: 10.1016/0009-8981(95)06126-2
– volume: 8
  start-page: 789458
  year: 2021
  ident: 69879_CR52
  publication-title: Front. Cardiovasc. Med.
  doi: 10.3389/fcvm.2021.789458
– volume: 135
  start-page: 1453
  year: 2022
  ident: 69879_CR50
  publication-title: Am. J. Med.
  doi: 10.1016/j.amjmed.2022.08.012
– volume: 23
  start-page: 470
  year: 2023
  ident: 69879_CR59
  publication-title: Curr. Top. Med. Chem.
  doi: 10.2174/1568026623666221213085917
– volume: 12
  start-page: 794437
  year: 2021
  ident: 69879_CR56
  publication-title: Front. Endocrinol. (Lausanne)
  doi: 10.3389/fendo.2021.794437
– volume: 25
  start-page: 7706
  year: 2024
  ident: 69879_CR28
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms25147706
– volume: 36
  start-page: 365
  year: 1999
  ident: 69879_CR39
  publication-title: Crit. Rev. Clin. Lab. Sci.
  doi: 10.1080/10408369991239231
– volume: 76
  start-page: 2982
  year: 2020
  ident: 69879_CR1
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2020.11.010
– volume: 15
  start-page: 3593
  year: 2023
  ident: 69879_CR15
  publication-title: Nutrients
  doi: 10.3390/nu15163593
– volume: 6
  start-page: 101037
  year: 2024
  ident: 69879_CR27
  publication-title: JHEP Rep.
  doi: 10.1016/j.jhepr.2024.101037
– volume: 26
  start-page: 86
  year: 2019
  ident: 69879_CR51
  publication-title: J. Nucl. Cardiol.
  doi: 10.1007/s12350-018-01506-w
– volume: 43
  start-page: 2119
  year: 2023
  ident: 69879_CR57
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.123.319674
– volume: 313
  start-page: 111
  year: 2020
  ident: 69879_CR8
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2020.09.029
– volume: 13
  start-page: 829425
  year: 2022
  ident: 69879_CR58
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2022.829425
– volume: 122
  start-page: 433
  year: 2018
  ident: 69879_CR26
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.117.312086
– volume: 296
  start-page: 11
  year: 2020
  ident: 69879_CR67
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2020.01.015
– volume: 50
  start-page: 769
  year: 2019
  ident: 69879_CR47
  publication-title: Aliment. Pharmacol. Ther.
  doi: 10.1111/apt.15446
– volume: 12
  start-page: 3340
  year: 2020
  ident: 69879_CR7
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.102815
– year: 2023
  ident: 69879_CR13
  publication-title: Front. Endocrinol.
  doi: 10.3389/fendo.2023.1291445
– volume: 46
  start-page: 1985
  year: 2017
  ident: 69879_CR31
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/dyx102
– volume: 23
  start-page: 452
  year: 1994
  ident: 69879_CR61
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/0735-1097(94)90433-2
– volume: 15
  start-page: e003501
  year: 2022
  ident: 69879_CR36
  publication-title: Circ. Genom. Precis. Med.
  doi: 10.1161/CIRCGEN.121.003501
– volume: 24
  start-page: 353
  year: 2005
  ident: 69879_CR55
  publication-title: J. Autoimmun.
  doi: 10.1016/j.jaut.2005.03.001
– volume: 170
  start-page: 60
  year: 2022
  ident: 69879_CR69
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2022.05.013
– volume: 24
  start-page: 988
  year: 2005
  ident: 69879_CR62
  publication-title: Clin. Nutr.
  doi: 10.1016/j.clnu.2005.07.003
– volume: 14
  start-page: 1277153
  year: 2023
  ident: 69879_CR18
  publication-title: Front. Endocrinol. (Lausanne)
  doi: 10.3389/fendo.2023.1277153
– volume: 41
  start-page: 10
  year: 2017
  ident: 69879_CR38
  publication-title: Eur. J. Intern. Med.
  doi: 10.1016/j.ejim.2017.03.019
– volume: 15
  start-page: 4787
  year: 2023
  ident: 69879_CR14
  publication-title: Nutrients
  doi: 10.3390/nu15224787
– volume: 20
  start-page: 475
  year: 2022
  ident: 69879_CR11
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-022-03691-2
– volume: 25
  start-page: 699
  year: 2015
  ident: 69879_CR46
  publication-title: Trends Cardiovasc. Med.
  doi: 10.1016/j.tcm.2015.03.010
– volume: 55
  start-page: 44
  year: 2023
  ident: 69879_CR24
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-022-01270-1
– volume: 15
  start-page: 1374938
  year: 2024
  ident: 69879_CR32
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2024.1374938
– volume: 129
  start-page: 261
  year: 1997
  ident: 69879_CR63
  publication-title: Atherosclerosis
  doi: 10.1016/S0021-9150(96)06044-3
– volume: 34
  start-page: 233
  year: 2000
  ident: 69879_CR40
  publication-title: Annu. Rev. Genet.
  doi: 10.1146/annurev.genet.34.1.233
– volume: 2
  start-page: 896
  year: 2017
  ident: 69879_CR54
  publication-title: JAMA Cardiol.
  doi: 10.1001/jamacardio.2017.1239
– volume: 14
  start-page: 2425
  year: 2021
  ident: 69879_CR37
  publication-title: JACC Cardiovasc. Imaging
  doi: 10.1016/j.jcmg.2021.06.013
– volume: 41
  start-page: 2645
  year: 2020
  ident: 69879_CR21
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehaa209
– volume: 234
  start-page: 16812
  year: 2019
  ident: 69879_CR3
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.28350
– volume: 77
  start-page: 230
  year: 2023
  ident: 69879_CR5
  publication-title: Hepatology
  doi: 10.1002/hep.32534
– volume: 32
  start-page: 377
  year: 2017
  ident: 69879_CR34
  publication-title: Eur. J. Epidemiol.
  doi: 10.1007/s10654-017-0255-x
– volume: 18
  start-page: 592
  year: 1995
  ident: 69879_CR42
  publication-title: J. Inherit. Metab. Dis.
  doi: 10.1007/BF02436004
– volume: 69
  start-page: 57
  year: 2019
  ident: 69879_CR10
  publication-title: Prog. Retin. Eye Res.
  doi: 10.1016/j.preteyeres.2018.11.002
– volume: 97
  start-page: 25
  year: 2015
  ident: 69879_CR49
  publication-title: Microvasc. Res.
  doi: 10.1016/j.mvr.2014.08.003
– volume: 13
  start-page: 21
  year: 2020
  ident: 69879_CR53
  publication-title: Nutrients
  doi: 10.3390/nu13010021
– volume: 41
  start-page: 12
  year: 2020
  ident: 69879_CR2
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehz859
– volume: 4
  start-page: 1434
  year: 1998
  ident: 69879_CR65
  publication-title: Nat. Med.
  doi: 10.1038/4027
– volume: 15
  start-page: 1016
  year: 2023
  ident: 69879_CR16
  publication-title: Nutrients
  doi: 10.3390/nu15041016
– volume: 31
  start-page: 283
  year: 2015
  ident: 69879_CR64
  publication-title: Nutrition
  doi: 10.1016/j.nut.2014.08.011
– volume: 14
  start-page: 1271942
  year: 2023
  ident: 69879_CR17
  publication-title: Front. Endocrinol. (Lausanne)
  doi: 10.3389/fendo.2023.1271942
– volume: 178
  start-page: 114065
  year: 2020
  ident: 69879_CR68
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2020.114065
– volume: 14
  start-page: 63
  year: 2022
  ident: 69879_CR6
  publication-title: Genome Med.
  doi: 10.1186/s13073-022-01067-1
– volume: 15
  start-page: 1580
  year: 2023
  ident: 69879_CR23
  publication-title: Nutrients
  doi: 10.3390/nu15071580
– volume: 17
  start-page: 451
  year: 2016
  ident: 69879_CR9
  publication-title: Nat. Rev. Mol. Cell. Biol.
  doi: 10.1038/nrm.2016.25
– volume: 44
  start-page: 313
  year: 2020
  ident: 69879_CR29
  publication-title: Genet. Epidemiol.
  doi: 10.1002/gepi.22295
– volume: 19
  start-page: 291
  year: 2022
  ident: 69879_CR4
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/s41569-021-00638-w
– volume: 12
  start-page: 114
  year: 2016
  ident: 69879_CR45
  publication-title: BMC Vet. Res.
  doi: 10.1186/s12917-016-0736-2
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Snippet The development of coronary artery disease (CAD) is significantly affected by impaired endocrine and metabolic status. Under this circumstance, improved...
Abstract The development of coronary artery disease (CAD) is significantly affected by impaired endocrine and metabolic status. Under this circumstance,...
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Asian People - genetics
Benzoic acid
Biomarker
Biomarkers
Biomarkers - blood
Blood
Cardiovascular disease
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - genetics
Coronary Artery Disease - metabolism
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Female
Glycerol
Heart diseases
Heterogeneity
Humanities and Social Sciences
Humans
Interception
Male
Mendelian randomization
Mendelian Randomization Analysis
Metabolic pathways
Metabolism
Metabolites
Metabolomics - methods
multidisciplinary
Plasma metabolites
Pleiotropy
Prevention
Ratios
Risk assessment
Science
Science (multidisciplinary)
Sensitivity analysis
Spermidine
Vein & artery diseases
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