Genomic RNA editing and its impact on Ebola virus adaptation during serial passages in cell culture and infection of guinea pigs

Synthesis of the structural, surface glycoprotein (GP) of Ebola virus (EBOV) is dependent on transcriptional RNA editing phenomenon. Editing results in the insertion of an extra adenosine by viral polymerase at the editing site (7 consecutive template uridines) during transcription of GP gene of the...

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Veröffentlicht in:	The Journal of infectious diseases Jg. 204 Suppl 3; S. S941
Hauptverfasser:	Volchkova, Valentina A, Dolnik, Olga, Martinez, Miguel J, Reynard, Olivier, Volchkov, Viktor E
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.11.2011
Schlagworte:	Adaptation, Physiological Animals Cercopithecus aethiops Ebolavirus - genetics Ebolavirus - physiology Female Gene Expression Regulation, Viral - physiology Genome, Viral - genetics Guinea Pigs Hemorrhagic Fever, Ebola - virology RNA Editing - physiology RNA, Viral - genetics Serial Passage Vero Cells Viral Proteins - genetics Viral Proteins - metabolism Virus Replication - physiology
ISSN:	1537-6613, 1537-6613
Online-Zugang:	Weitere Angaben
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