The thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity

Checkpoint kinase 1 (CHK1) is critical for cell survival under replication stress (RS). CHK1 inhibitors (CHK1i’s) in combination with chemotherapy have shown promising results in preclinical studies but have displayed minimal efficacy with substantial toxicity in clinical trials. To explore combinat...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 4667 - 23
Main Authors:	Prasad, Chandra Bhushan, Oo, Adrian, Liu, Yujie, Qiu, Zhaojun, Zhong, Yaogang, Li, Na, Singh, Deepika, Xin, Xiwen, Cho, Young-Jae, Li, Zaibo, Zhang, Xiaoli, Yan, Chunhong, Zheng, Qingfei, Wang, Qi-En, Guo, Deliang, Kim, Baek, Zhang, Junran
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 31.05.2024 Nature Publishing Group Nature Portfolio
Subjects:	13 13/106 13/2 42 42/70 49 49/47 631/67/1612 631/67/1612/1350 64 64/60 692/4028/67/1059/2326 Animals Auranofin - pharmacology Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Cell survival Checkpoint Kinase 1 - antagonists & inhibitors Checkpoint Kinase 1 - metabolism Chemotherapy CHK1 protein Clinical trials Combinatorial analysis Drug Synergism Effectiveness Humanities and Social Sciences Humans Inhibitors Kinases Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Mammals multidisciplinary Non-small cell lung carcinoma Oxidation-Reduction - drug effects Protein Kinase Inhibitors - pharmacology Reductase Reductases Rheumatoid arthritis Ribonucleoside Diphosphate Reductase - genetics Ribonucleoside Diphosphate Reductase - metabolism Ribonucleotide reductase Ribonucleotide Reductases - antagonists & inhibitors Ribonucleotide Reductases - metabolism Science Science (multidisciplinary) Sensitivity Small cell lung carcinoma Synergistic effect Thioredoxin Thioredoxins - metabolism Toxicity
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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