Melatonin reduces membrane rigidity and oxidative damage in the brain of SAMP8 mice

We evaluated the autophagy-lysosomal pathway and membrane fluidity in brain cells and mitochondrial membranes obtained from senescence-accelerated (SAMP8) and senescence-resistant (SAMR1) mice at 5 and 10 months of age. Moreover, we studied whether chronic treatment from age 1 to 10 months with mela...

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Bibliographic Details
Published in:	Neurobiology of aging Vol. 32; no. 11; pp. 2045 - 2054
Main Authors:	García, J.J., Piñol-Ripoll, G., Martínez-Ballarín, E., Fuentes-Broto, L., Miana-Mena, F.J., Venegas, C., Caballero, B., Escames, G., Coto-Montes, A., Acuña-Castroviejo, D.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.11.2011
Subjects:	Aging Aging, Premature - metabolism Animals Brain - drug effects Brain - metabolism Cathepsin B - metabolism Cathepsin D - metabolism Cell Membrane - drug effects Cell Membrane - metabolism Female Internal Medicine Male Melatonin Melatonin - pharmacology Membrane fluidity Membrane Fluidity - drug effects Mice Mice, Transgenic Mitochondria Mitochondria - drug effects Mitochondria - metabolism Neurology Oxidative stress Oxidative Stress - drug effects Senescence-accelerated mice Aging Oxidative stress Senescence-accelerated mice Melatonin Membrane fluidity Mitochondria
ISSN:	0197-4580, 1558-1497, 1558-1497
Online Access:	Get full text
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