Integrative single-cell RNA-seq and spatial transcriptomics analyses reveal diverse apoptosis-related gene expression profiles in EGFR-mutated lung cancer

In EGFR -mutated lung cancer, the duration of response to tyrosine kinase inhibitors (TKIs) is limited by the development of acquired drug resistance. Despite the crucial role played by apoptosis-related genes in tumor cell survival, how their expression changes as resistance to EGFR-TKIs emerges re...

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Bibliographic Details
Published in:	Cell death & disease Vol. 15; no. 8; pp. 580 - 11
Main Authors:	Izumi, Motohiro, Fujii, Masanori, Kobayashi, Ikei S., Ho, Vivian, Kashima, Yukie, Udagawa, Hibiki, Costa, Daniel B., Kobayashi, Susumu S.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 09.08.2024 Springer Nature B.V Nature Publishing Group
Subjects:	13/1 13/109 38/39 38/91 631/337/2019 631/67/1612/1350 Animals Antibodies Apoptosis Apoptosis - drug effects Apoptosis - genetics Bcl-2 protein Bcl-x protein bcl-X Protein - genetics bcl-X Protein - metabolism Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell Line, Tumor Cell survival Drug resistance Drug Resistance, Neoplasm - genetics Epidermal growth factor receptors ErbB Receptors - genetics ErbB Receptors - metabolism Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic analysis Humans Immunology Kinases Life Sciences Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Mcl-1 protein Mice Mice, Transgenic Mutation - genetics Nucleotide sequence Protein Kinase Inhibitors - pharmacology RNA-Seq Single-Cell Analysis Single-Cell Gene Expression Analysis Spatial heterogeneity Transcriptome - genetics Transcriptomics Transgenic mice Tumor cell lines Tumor cells Tumors Tyrosine kinase inhibitors
ISSN:	2041-4889, 2041-4889
Online Access:	Get full text
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