IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines

The use of lipid-formulated RNA vaccines for cancer or COVID-19 is associated with dose-limiting systemic inflammatory responses in humans that were not predicted from preclinical studies. Here, we show that the 'interleukin 1 (IL-1)-interleukin 1 receptor antagonist (IL-1ra)' axis regulat...

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Vydané v:	Nature immunology Ročník 23; číslo 4; s. 532 - 542
Hlavní autori:	Tahtinen, Siri, Tong, Ann-Jay, Himmels, Patricia, Oh, Jaehak, Paler-Martinez, Andres, Kim, Leesun, Wichner, Sara, Oei, Yoko, McCarron, Mark J, Freund, Emily C, Amir, Zhainib Adel, de la Cruz, Cecile C, Haley, Benjamin, Blanchette, Craig, Schartner, Jill M, Ye, Weilan, Yadav, Mahesh, Sahin, Ugur, Delamarre, Lélia, Mellman, Ira
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Nature Publishing Group 01.04.2022
Predmet:	Animals Cancer vaccines COVID-19 Cytokines IL-1β Inflammation Inflammation - immunology Inflammation - metabolism Interleukin 1 Interleukin 1 receptor antagonist Interleukin 1 Receptor Antagonist Protein - genetics Interleukin 1 Receptor Antagonist Protein - immunology Interleukin 1 receptors Interleukin 6 Interleukin-1 - genetics Interleukin-1 - immunology Leukocytes Lipids Mice mRNA vaccines mRNA Vaccines - adverse effects mRNA Vaccines - metabolism Ribonucleic acid RNA Signal transduction Toll-like receptors Vaccines Vaccines, Synthetic
ISSN:	1529-2908, 1529-2916, 1529-2916
On-line prístup:	Získať plný text
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