IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines

The use of lipid-formulated RNA vaccines for cancer or COVID-19 is associated with dose-limiting systemic inflammatory responses in humans that were not predicted from preclinical studies. Here, we show that the 'interleukin 1 (IL-1)-interleukin 1 receptor antagonist (IL-1ra)' axis regulat...

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Bibliographic Details
Published in:	Nature immunology Vol. 23; no. 4; pp. 532 - 542
Main Authors:	Tahtinen, Siri, Tong, Ann-Jay, Himmels, Patricia, Oh, Jaehak, Paler-Martinez, Andres, Kim, Leesun, Wichner, Sara, Oei, Yoko, McCarron, Mark J, Freund, Emily C, Amir, Zhainib Adel, de la Cruz, Cecile C, Haley, Benjamin, Blanchette, Craig, Schartner, Jill M, Ye, Weilan, Yadav, Mahesh, Sahin, Ugur, Delamarre, Lélia, Mellman, Ira
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01.04.2022
Subjects:	Animals Cancer vaccines COVID-19 Cytokines IL-1β Inflammation Inflammation - immunology Inflammation - metabolism Interleukin 1 Interleukin 1 receptor antagonist Interleukin 1 Receptor Antagonist Protein - genetics Interleukin 1 Receptor Antagonist Protein - immunology Interleukin 1 receptors Interleukin 6 Interleukin-1 - genetics Interleukin-1 - immunology Leukocytes Lipids Mice mRNA vaccines mRNA Vaccines - adverse effects mRNA Vaccines - metabolism Ribonucleic acid RNA Signal transduction Toll-like receptors Vaccines Vaccines, Synthetic
ISSN:	1529-2908, 1529-2916, 1529-2916
Online Access:	Get full text
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