IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines

The use of lipid-formulated RNA vaccines for cancer or COVID-19 is associated with dose-limiting systemic inflammatory responses in humans that were not predicted from preclinical studies. Here, we show that the 'interleukin 1 (IL-1)-interleukin 1 receptor antagonist (IL-1ra)' axis regulat...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Nature immunology Ročník 23; číslo 4; s. 532 - 542
Hlavní autoři:	Tahtinen, Siri, Tong, Ann-Jay, Himmels, Patricia, Oh, Jaehak, Paler-Martinez, Andres, Kim, Leesun, Wichner, Sara, Oei, Yoko, McCarron, Mark J, Freund, Emily C, Amir, Zhainib Adel, de la Cruz, Cecile C, Haley, Benjamin, Blanchette, Craig, Schartner, Jill M, Ye, Weilan, Yadav, Mahesh, Sahin, Ugur, Delamarre, Lélia, Mellman, Ira
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Nature Publishing Group 01.04.2022
Témata:	Animals Cancer vaccines COVID-19 Cytokines IL-1β Inflammation Inflammation - immunology Inflammation - metabolism Interleukin 1 Interleukin 1 receptor antagonist Interleukin 1 Receptor Antagonist Protein - genetics Interleukin 1 Receptor Antagonist Protein - immunology Interleukin 1 receptors Interleukin 6 Interleukin-1 - genetics Interleukin-1 - immunology Leukocytes Lipids Mice mRNA vaccines mRNA Vaccines - adverse effects mRNA Vaccines - metabolism Ribonucleic acid RNA Signal transduction Toll-like receptors Vaccines Vaccines, Synthetic
ISSN:	1529-2908, 1529-2916, 1529-2916
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!