Ketogenic diet in endocrine disorders Current perspectives

Ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis, long known for antiepileptic effects and has been used therapeutically to treat refractory epilepsy. This review attempts to summarize the evidence and clinical application of KD in diab...

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Bibliographic Details
Published in:Journal of postgraduate medicine Vol. 63; no. 4; pp. 242 - 251
Main Authors: Gupta, L, Khandelwal, D, Kalra, S, Gupta, P, Dutta, D, Aggarwal, S
Format: Journal Article
Language:English
Published: India Medknow Publications and Media Pvt. Ltd 01.10.2017
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Subjects:
Amino acids
Anticonvulsants
Brain research
Carbohydrates
Carbon dioxide
Care and treatment
Convulsions & seizures
Diabetes
Diet
Dosage and administration
Endocrine diseases
Endocrinology
Epilepsy
Fatty acids
Free radicals
Heart
High fat diet
Ketosis
Liver
Metabolism
Nervous system
Neurological disorders
Nutrition research
Physiological aspects
Proteins
Respiratory failure
Review
Rodents
ISSN:0022-3859, 0972-2823, 0972-2823
Online Access:Get full text
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Summary:Ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis, long known for antiepileptic effects and has been used therapeutically to treat refractory epilepsy. This review attempts to summarize the evidence and clinical application of KD in diabetes, obesity, and other endocrine disorders. KD is usually animal protein based. An empiric vegetarian Indian variant of KD has been provided keeping in mind the Indian food habits. KD has beneficial effects on cardiac ischemic preconditioning, improves oxygenation in patients with respiratory failure, improves glycemic control in diabetics, is associated with significant weight loss, and has a beneficial impact on polycystic ovarian syndrome. Multivitamin supplementations are recommended with KD. Recently, ketones are being proposed as super-metabolic fuel; and KD is currently regarded as apt dietary therapy for "diabesity."
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ISSN:0022-3859
0972-2823
0972-2823
DOI:10.4103/jpgm.JPGM_16_17