Ketogenic diet in endocrine disorders Current perspectives

Ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis, long known for antiepileptic effects and has been used therapeutically to treat refractory epilepsy. This review attempts to summarize the evidence and clinical application of KD in diab...

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Published in:	Journal of postgraduate medicine Vol. 63; no. 4; pp. 242 - 251
Main Authors:	Gupta, L, Khandelwal, D, Kalra, S, Gupta, P, Dutta, D, Aggarwal, S
Format:	Journal Article
Language:	English
Published:	India Medknow Publications and Media Pvt. Ltd 01.10.2017 Medknow Publications & Media Pvt. Ltd Medknow Publications & Media Pvt Ltd
Subjects:	Amino acids Anticonvulsants Brain research Carbohydrates Carbon dioxide Care and treatment Convulsions & seizures Diabetes Diet Dosage and administration Endocrine diseases Endocrinology Epilepsy Fatty acids Free radicals Heart High fat diet Ketosis Liver Metabolism Nervous system Neurological disorders Nutrition research Physiological aspects Proteins Respiratory failure Review Rodents
ISSN:	0022-3859, 0972-2823, 0972-2823
Online Access:	Get full text
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Abstract	Ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis, long known for antiepileptic effects and has been used therapeutically to treat refractory epilepsy. This review attempts to summarize the evidence and clinical application of KD in diabetes, obesity, and other endocrine disorders. KD is usually animal protein based. An empiric vegetarian Indian variant of KD has been provided keeping in mind the Indian food habits. KD has beneficial effects on cardiac ischemic preconditioning, improves oxygenation in patients with respiratory failure, improves glycemic control in diabetics, is associated with significant weight loss, and has a beneficial impact on polycystic ovarian syndrome. Multivitamin supplementations are recommended with KD. Recently, ketones are being proposed as super-metabolic fuel; and KD is currently regarded as apt dietary therapy for "diabesity."
AbstractList	Ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis, long known for antiepileptic effects and has been used therapeutically to treat refractory epilepsy. This review attempts to summarize the evidence and clinical application of KD in diabetes, obesity, and other endocrine disorders. KD is usually animal protein based. An empiric vegetarian Indian variant of KD has been provided keeping in mind the Indian food habits. KD has beneficial effects on cardiac ischemic preconditioning, improves oxygenation in patients with respiratory failure, improves glycemic control in diabetics, is associated with significant weight loss, and has a beneficial impact on polycystic ovarian syndrome. Multivitamin supplementations are recommended with KD. Recently, ketones are being proposed as super-metabolic fuel; and KD is currently regarded as apt dietary therapy for "diabesity." Ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis, long known for antiepileptic effects and has been used therapeutically to treat refractory epilepsy. This review attempts to summarize the evidence and clinical application of KD in diabetes, obesity, and other endocrine disorders. KD is usually animal protein based. An empiric vegetarian Indian variant of KD has been provided keeping in mind the Indian food habits. KD has beneficial effects on cardiac ischemic preconditioning, improves oxygenation in patients with respiratory failure, improves glycemic control in diabetics, is associated with significant weight loss, and has a beneficial impact on polycystic ovarian syndrome. Multivitamin supplementations are recommended with KD. Recently, ketones are being proposed as super-metabolic fuel; and KD is currently regarded as apt dietary therapy for "diabesity."Ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis, long known for antiepileptic effects and has been used therapeutically to treat refractory epilepsy. This review attempts to summarize the evidence and clinical application of KD in diabetes, obesity, and other endocrine disorders. KD is usually animal protein based. An empiric vegetarian Indian variant of KD has been provided keeping in mind the Indian food habits. KD has beneficial effects on cardiac ischemic preconditioning, improves oxygenation in patients with respiratory failure, improves glycemic control in diabetics, is associated with significant weight loss, and has a beneficial impact on polycystic ovarian syndrome. Multivitamin supplementations are recommended with KD. Recently, ketones are being proposed as super-metabolic fuel; and KD is currently regarded as apt dietary therapy for "diabesity."
Audience	General
Author	Kalra, S Dutta, D Gupta, L Gupta, P Aggarwal, S Khandelwal, D
AuthorAffiliation	5 Department of Medicine, Division of Endocrinology, Pandit Bhagwat Dayal Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India 2 Department of Endocrinology, Bharti Hospital and Bharti Research Institute of Diabetes and Endocrinology, Karnal, Haryana, India Department of Dietetics, Maharaja Agrasen Hospital, New Delhi, India 4 Department of Endocrinology, Venkateshwar Hospitals, New Delhi, India 1 Department of Endocrinology, Maharaja Agrasen Hospital, New Delhi, India 3 Department of Paediatrics, Maharaja Agrasen Hospital, New Delhi, India
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Snippet	Ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis, long known for antiepileptic effects and has...
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SubjectTerms	Amino acids Anticonvulsants Brain research Carbohydrates Carbon dioxide Care and treatment Convulsions & seizures Diabetes Diet Dosage and administration Endocrine diseases Endocrinology Epilepsy Fatty acids Free radicals Heart High fat diet Ketosis Liver Metabolism Nervous system Neurological disorders Nutrition research Physiological aspects Proteins Respiratory failure Review Rodents
Subtitle	Current perspectives
Title	Ketogenic diet in endocrine disorders
URI	https://www.ncbi.nlm.nih.gov/pubmed/29022562 https://www.proquest.com/docview/1954848544 https://www.proquest.com/docview/1950417639 https://pubmed.ncbi.nlm.nih.gov/PMC5664869
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