Long-Term Trends of Coagulation Parameters in People Living With HIV Treated With Combined Antiretroviral Therapy

Trends of coagulation parameters during long-term treatment with combination antiretroviral therapy (cART) are unclear. We followed 40 male subjects living with human immunodeficiency virus (HIV). Plasma levels of procoagulant parameters, factor VIII, von Willebrand factor and D-dimer, and anticoagu...

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Vydané v:Clinical and applied thrombosis/hemostasis Ročník 29; s. 10760296231165492
Hlavní autori: Bhoelan, Soerajja, Borjas Howard, Jaime, Tichelaar, Vladimir, Bierman, Wouter, Meijer, Karina
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Los Angeles, CA SAGE Publications 01.01.2023
SAGE PUBLICATIONS, INC
SAGE Publishing
Predmet:
Anti-Retroviral Agents - therapeutic use
Antiretroviral drugs
Blood Coagulation
Drug therapy
Health risks
HIV
HIV - metabolism
HIV Infections - drug therapy
Human immunodeficiency virus
Humans
Male
Original Manuscript
Trends
von Willebrand Factor - metabolism
thrombosis
aging
HIV
anti-HIV agents
blood coagulation
ISSN:1076-0296, 1938-2723, 1938-2723
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Shrnutí:Trends of coagulation parameters during long-term treatment with combination antiretroviral therapy (cART) are unclear. We followed 40 male subjects living with human immunodeficiency virus (HIV). Plasma levels of procoagulant parameters, factor VIII, von Willebrand factor and D-dimer, and anticoagulant parameter Protein S (PS), were measured before start and 3 months, 1 year, and 9 years after. Analyses were adjusted for cardiovascular risk factors (age, smoking, and hypertension) at baseline. At baseline, procoagulant parameters were markedly elevated and PS was in the lower range of normal. CD4/CD8-ratio improved during the complete follow-up period. In the first year, procoagulant parameters were decreasing, but at year 9 an increase was observed. After correction for cardiovascular risk factors, this increase was no longer present. PS remained stable during the first year and slightly increased from one to 9 years. This study indicates that decreasing immune activation by cART reverses the procoagulant state in HIV partially during the first year. These parameters increase in the long term despite an on-going decrease in immune activation. This increase might be related to established cardiovascular risk factors.
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ISSN:1076-0296
1938-2723
1938-2723
DOI:10.1177/10760296231165492