Therapeutically harnessing extracellular vesicles

The field of extracellular vesicle (EV) research has developed rapidly over the last decade from the study of fundamental biology to a subject of significant clinical relevance. The potential of harnessing EVs in the diagnosis and treatment of diseases - including cancer and neurological and cardiov...

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Veröffentlicht in:Nature reviews. Drug discovery Jg. 21; H. 5; S. 379 - 399
Hauptverfasser: Cheng, Lesley, Hill, Andrew F
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Nature Publishing Group 01.05.2022
Schlagworte:
Biomarkers
Biosynthesis
Cancer
Cardiovascular Diseases
Disease
Extracellular Vesicles
Humans
Neoplasms - drug therapy
Pathology
Physiology
Plasma
Proteins
ISSN:1474-1776, 1474-1784, 1474-1784
Online-Zugang:Volltext
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Zusammenfassung:The field of extracellular vesicle (EV) research has developed rapidly over the last decade from the study of fundamental biology to a subject of significant clinical relevance. The potential of harnessing EVs in the diagnosis and treatment of diseases - including cancer and neurological and cardiovascular disorders - is now being recognized. Accordingly, the applications of EVs as therapeutic targets, biomarkers, novel drug delivery agents and standalone therapeutics are being actively explored. This Review provides a brief overview of the characteristics and physiological functions of the various classes of EV, focusing on their association with disease and emerging strategies for their therapeutic exploitation.
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ISSN:1474-1776
1474-1784
1474-1784
DOI:10.1038/s41573-022-00410-w