Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid

The extracellular matrix (ECM) components play key roles in the multistep process of cancer growth and progression. Preclinical and clinical data show that bisphosphonates (BPs) may exert direct or indirect antitumoral effects. Despite proven efficiency in cancer treatment, the mechanism by which BP...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1820; no. 12; pp. 1926 - 1939
Main Authors:	Dedes, P.G., Gialeli, Ch, Tsonis, A.I., Kanakis, I., Theocharis, A.D., Kletsas, D., Tzanakakis, G.N., Karamanos, N.K.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.12.2012
Subjects:	Adhesion antineoplastic agents Blotting, Western Bone Density Conservation Agents - pharmacology Breast cancer breast neoplasms Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology cell adhesion Cell Adhesion - drug effects Cell Movement - drug effects Cell Proliferation - drug effects Diphosphonates - pharmacology Extracellular matrix Extracellular Matrix - metabolism Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Female functional properties gene expression Gene Expression Regulation, Neoplastic - drug effects heparan sulfate Humans hyaluronic acid Imidazoles - pharmacology integrins Invasion metalloproteinases metastasis Migration neoplasm cells proteoglycans Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Tumor Cells, Cultured Wound Healing - drug effects Zoledronate LN BPs Migration FN Breast cancer COL-IV Zoledronate Adhesion ECM Invasion MT-MMP COL II MMP FAK ZOL PG VN HA TIMPs Extracellular matrix TN COL I PKCa
ISSN:	0304-4165, 0006-3002, 1872-8006
Online Access:	Get full text
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