Permeant anions contribute to voltage dependence of ClC‐2 chloride channel by interacting with the protopore gate

It has been shown that the voltage (Vm) dependence of ClC Cl− channels is conferred by interaction of the protopore gate with H+ ions. However, in this paper we present evidence which indicates that permeant Cl− ions contribute to Vm‐dependent gating of the broadly distributed ClC‐2 Cl− channel. The...

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Bibliographic Details

Published in:	The Journal of physiology Vol. 588; no. 14; pp. 2545 - 2556
Main Authors:	Sánchez‐Rodríguez, Jorge E., De Santiago‐Castillo, José A., Arreola, Jorge
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 15.07.2010 Wiley Subscription Services, Inc Blackwell Science Inc
Subjects:	Animals Binding sites Cells, Cultured Chloride Channels - physiology Chlorides - metabolism Chlorides - physiology Dependence Ion Channel Gating - physiology Mice Molecular and Cellular Parotid Gland - physiology Physiology Potassium Rodents Thiocyanates - pharmacology
ISSN:	0022-3751, 1469-7793, 1469-7793
Online Access:	Get full text
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