Paracetamol poisoning: beyond the nomogram

Paracetamol poisoning is the commonest overdose seen in the UK. The management of patients with paracetamol poisoning has been little changed for the past 40 years, with a weight related dose of antidote (acetylcysteine) and treatment based on nomograms relating paracetamol concentration to time fro...

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Published in:British journal of clinical pharmacology Vol. 80; no. 1; pp. 45 - 50
Main Author: Bateman, D. Nicholas
Format: Journal Article
Language:English
Published: England John Wiley & Sons, Ltd 01.07.2015
Subjects:
Acetaminophen - administration & dosage
Acetaminophen - poisoning
acetylcysteine
Acetylcysteine - administration & dosage
Acetylcysteine - therapeutic use
Analgesics, Non-Narcotic - administration & dosage
Analgesics, Non-Narcotic - poisoning
antidotes
aracetamol
biomarkers
Biomarkers - blood
Drug Overdose - drug therapy
Humans
Nomograms
poisoning
Reviews
Risk Assessment - methods
acetylcysteine
antidotes
aracetamol
poisoning
biomarkers
ISSN:0306-5251, 1365-2125, 1365-2125
Online Access:Get full text
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Abstract Paracetamol poisoning is the commonest overdose seen in the UK. The management of patients with paracetamol poisoning has been little changed for the past 40 years, with a weight related dose of antidote (acetylcysteine) and treatment based on nomograms relating paracetamol concentration to time from ingestion. In 2012 the UK Commission on Human Medicines recommended a revision of the nomogram, following the death of a young woman, lowering the treatment threshold for all patients. As a result many more patients were treated. This has resulted in a large increase in admissions and in the proportion suffering adverse reactions to the antidote acetylcysteine since, interestingly, higher paracetamol concentrations inhibit anaphylactoid reactions to the antidote. New approaches to assessing the toxicity of paracetamol are now emerging using new biomarkers in blood. This article discusses new approaches to risk assessment and treatment for paracetamol overdose based on recent research in this area.
AbstractList Paracetamol poisoning is the commonest overdose seen in the UK. The management of patients with paracetamol poisoning has been little changed for the past 40 years, with a weight related dose of antidote (acetylcysteine) and treatment based on nomograms relating paracetamol concentration to time from ingestion. In 2012 the UK Commission on Human Medicines recommended a revision of the nomogram, following the death of a young woman, lowering the treatment threshold for all patients. As a result many more patients were treated. This has resulted in a large increase in admissions and in the proportion suffering adverse reactions to the antidote acetylcysteine since, interestingly, higher paracetamol concentrations inhibit anaphylactoid reactions to the antidote. New approaches to assessing the toxicity of paracetamol are now emerging using new biomarkers in blood. This article discusses new approaches to risk assessment and treatment for paracetamol overdose based on recent research in this area.
Paracetamol poisoning is the commonest overdose seen in the UK. The management of patients with paracetamol poisoning has been little changed for the past 40 years, with a weight related dose of antidote (acetylcysteine) and treatment based on nomograms relating paracetamol concentration to time from ingestion. In 2012 the UK Commission on Human Medicines recommended a revision of the nomogram, following the death of a young woman, lowering the treatment threshold for all patients. As a result many more patients were treated. This has resulted in a large increase in admissions and in the proportion suffering adverse reactions to the antidote acetylcysteine since, interestingly, higher paracetamol concentrations inhibit anaphylactoid reactions to the antidote. New approaches to assessing the toxicity of paracetamol are now emerging using new biomarkers in blood. This article discusses new approaches to risk assessment and treatment for paracetamol overdose based on recent research in this area.Paracetamol poisoning is the commonest overdose seen in the UK. The management of patients with paracetamol poisoning has been little changed for the past 40 years, with a weight related dose of antidote (acetylcysteine) and treatment based on nomograms relating paracetamol concentration to time from ingestion. In 2012 the UK Commission on Human Medicines recommended a revision of the nomogram, following the death of a young woman, lowering the treatment threshold for all patients. As a result many more patients were treated. This has resulted in a large increase in admissions and in the proportion suffering adverse reactions to the antidote acetylcysteine since, interestingly, higher paracetamol concentrations inhibit anaphylactoid reactions to the antidote. New approaches to assessing the toxicity of paracetamol are now emerging using new biomarkers in blood. This article discusses new approaches to risk assessment and treatment for paracetamol overdose based on recent research in this area.
Author Bateman, D. Nicholas
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Keywords acetylcysteine
antidotes
aracetamol
poisoning
biomarkers
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Snippet Paracetamol poisoning is the commonest overdose seen in the UK. The management of patients with paracetamol poisoning has been little changed for the past 40...
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SubjectTerms Acetaminophen - administration & dosage
Acetaminophen - poisoning
acetylcysteine
Acetylcysteine - administration & dosage
Acetylcysteine - therapeutic use
Analgesics, Non-Narcotic - administration & dosage
Analgesics, Non-Narcotic - poisoning
antidotes
aracetamol
biomarkers
Biomarkers - blood
Drug Overdose - drug therapy
Humans
Nomograms
poisoning
Reviews
Risk Assessment - methods
Title Paracetamol poisoning: beyond the nomogram
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fbcp.12604
https://www.ncbi.nlm.nih.gov/pubmed/26099917
https://www.proquest.com/docview/1691017086
https://pubmed.ncbi.nlm.nih.gov/PMC4500323
Volume 80
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