Evaluation of the physical properties and stability of two lipid drug delivery systems containing mefloquine

Stability data is used to determine the change the product has undergone over a certain time period at specific temperatures. In the present study, the physical stability characterized by size, pH and entrapment efficacy of mefloquine loaded liposomes and Pheroid™ vesicles were investigated. Size wa...

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Bibliographic Details
Published in:International journal of pharmaceutics Vol. 409; no. 1; pp. 209 - 215
Main Authors: Slabbert, C., Plessis, L.H. du, Kotzé, A.F.
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 16.05.2011
Elsevier
Subjects:
Antimalarials - administration & dosage
Antimalarials - chemistry
Bioavailability
Biological and medical sciences
Colloids
Data processing
Drug delivery
Drug delivery system
Drug Delivery Systems
Drug Stability
Drug Storage
drugs
Fatty Acids - chemistry
Flow Cytometry
General pharmacology
Hydrogen-Ion Concentration
Lipid bilayers
Liposome
Liposomes
Medical sciences
Mefloquine
Mefloquine - administration & dosage
Mefloquine - chemistry
Mefloquine hydrochloride
Particle Size
pH effects
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Pheroid™ Technology
Spectrophotometry, Ultraviolet
Stability Characterization
Storage conditions
Temperature
Temperature effects
Toxicity
Vesicles
EE
PBS
MQ
Liposome
ICH
Stability Characterization
Mefloquine hydrochloride
Pheroid™ Technology
RH
FSC
CLSM
Drug delivery system
WHO
Antimalarial
Evaluation
Mefloquine
Stability
Pharmaceutical technology
Lipids
Drug carrier
Physical properties
Characterization
Parasiticide
Physicochemical properties
ISSN:0378-5173, 1873-3476, 1873-3476
Online Access:Get full text
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Summary:Stability data is used to determine the change the product has undergone over a certain time period at specific temperatures. In the present study, the physical stability characterized by size, pH and entrapment efficacy of mefloquine loaded liposomes and Pheroid™ vesicles were investigated. Size was accurately determined by flow cytometry. Entrapment efficacy, after unentrapped drug was removed was successfully determined by UV-spectrophotometry. The formulations contained 0.5% (m/v) mefloquine and results showed that mefloquine interfered with the formation of lipid bilayer of the liposomes. Liposomes increased in size from 5.22 ± 0.03 μm to 9.71 ± 1.11 μm with accelerated stability and large aggregates were observed. A notable difference in stability testing of Pheroid™ vesicles was seen with no significant increase in size. Entrapment efficacy of 68.72 ± 0.04% (5 °C), 67.45 ± 2.92% (25 °C) and 67.45 ± 2.92% (30 °C) were obtained at the different storage conditions. With these findings the mefloquine loaded Pheroid™ vesicles are stable and should be used investigated for the possible increase in efficacy and bioavailability and decrease toxicity.
Bibliography:http://dx.doi.org/10.1016/j.ijpharm.2011.01.050
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ISSN:0378-5173
1873-3476
1873-3476
DOI:10.1016/j.ijpharm.2011.01.050