Evaluation of the physical properties and stability of two lipid drug delivery systems containing mefloquine

Stability data is used to determine the change the product has undergone over a certain time period at specific temperatures. In the present study, the physical stability characterized by size, pH and entrapment efficacy of mefloquine loaded liposomes and Pheroid™ vesicles were investigated. Size wa...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	International journal of pharmaceutics Ročník 409; číslo 1; s. 209 - 215
Hlavní autori:	Slabbert, C., Plessis, L.H. du, Kotzé, A.F.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Amsterdam Elsevier B.V 16.05.2011 Elsevier
Predmet:	Antimalarials - administration & dosage Antimalarials - chemistry Bioavailability Biological and medical sciences Colloids Data processing Drug delivery Drug delivery system Drug Delivery Systems Drug Stability Drug Storage drugs Fatty Acids - chemistry Flow Cytometry General pharmacology Hydrogen-Ion Concentration Lipid bilayers Liposome Liposomes Medical sciences Mefloquine Mefloquine - administration & dosage Mefloquine - chemistry Mefloquine hydrochloride Particle Size pH effects Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pheroid™ Technology Spectrophotometry, Ultraviolet Stability Characterization Storage conditions Temperature Temperature effects Toxicity Vesicles EE PBS MQ Liposome ICH Stability Characterization Mefloquine hydrochloride Pheroid™ Technology RH FSC CLSM Drug delivery system WHO Antimalarial Evaluation Mefloquine Stability Pharmaceutical technology Lipids Drug carrier Physical properties Characterization Parasiticide Physicochemical properties
ISSN:	0378-5173, 1873-3476, 1873-3476
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	Stability data is used to determine the change the product has undergone over a certain time period at specific temperatures. In the present study, the physical stability characterized by size, pH and entrapment efficacy of mefloquine loaded liposomes and Pheroid™ vesicles were investigated. Size was accurately determined by flow cytometry. Entrapment efficacy, after unentrapped drug was removed was successfully determined by UV-spectrophotometry. The formulations contained 0.5% (m/v) mefloquine and results showed that mefloquine interfered with the formation of lipid bilayer of the liposomes. Liposomes increased in size from 5.22 ± 0.03 μm to 9.71 ± 1.11 μm with accelerated stability and large aggregates were observed. A notable difference in stability testing of Pheroid™ vesicles was seen with no significant increase in size. Entrapment efficacy of 68.72 ± 0.04% (5 °C), 67.45 ± 2.92% (25 °C) and 67.45 ± 2.92% (30 °C) were obtained at the different storage conditions. With these findings the mefloquine loaded Pheroid™ vesicles are stable and should be used investigated for the possible increase in efficacy and bioavailability and decrease toxicity.
AbstractList	Stability data is used to determine the change the product has undergone over a certain time period at specific temperatures. In the present study, the physical stability characterized by size, pH and entrapment efficacy of mefloquine loaded liposomes and Pheroid™ vesicles were investigated. Size was accurately determined by flow cytometry. Entrapment efficacy, after unentrapped drug was removed was successfully determined by UV-spectrophotometry. The formulations contained 0.5% (m/v) mefloquine and results showed that mefloquine interfered with the formation of lipid bilayer of the liposomes. Liposomes increased in size from 5.22±0.03μm to 9.71±1.11μm with accelerated stability and large aggregates were observed. A notable difference in stability testing of Pheroid™ vesicles was seen with no significant increase in size. Entrapment efficacy of 68.72±0.04% (5°C), 67.45±2.92% (25°C) and 67.45±2.92% (30°C) were obtained at the different storage conditions. With these findings the mefloquine loaded Pheroid™ vesicles are stable and should be used investigated for the possible increase in efficacy and bioavailability and decrease toxicity. Stability data is used to determine the change the product has undergone over a certain time period at specific temperatures. In the present study, the physical stability characterized by size, pH and entrapment efficacy of mefloquine loaded liposomes and Pheroid[TM] vesicles were investigated. Size was accurately determined by flow cytometry. Entrapment efficacy, after unentrapped drug was removed was successfully determined by UV-spectrophotometry. The formulations contained 0.5% (m/v) mefloquine and results showed that mefloquine interfered with the formation of lipid bilayer of the liposomes. Liposomes increased in size from 5.22 +/- 0.03 [micro]m to 9.71 +/- 1.11 [micro]m with accelerated stability and large aggregates were observed. A notable difference in stability testing of Pheroid[TM] vesicles was seen with no significant increase in size. Entrapment efficacy of 68.72 +/- 0.04% (5 [deg]C), 67.45 +/- 2.92% (25 [deg]C) and 67.45 +/- 2.92% (30 [deg]C) were obtained at the different storage conditions. With these findings the mefloquine loaded Pheroid[TM] vesicles are stable and should be used investigated for the possible increase in efficacy and bioavailability and decrease toxicity. Stability data is used to determine the change the product has undergone over a certain time period at specific temperatures. In the present study, the physical stability characterized by size, pH and entrapment efficacy of mefloquine loaded liposomes and Pheroid™ vesicles were investigated. Size was accurately determined by flow cytometry. Entrapment efficacy, after unentrapped drug was removed was successfully determined by UV-spectrophotometry. The formulations contained 0.5% (m/v) mefloquine and results showed that mefloquine interfered with the formation of lipid bilayer of the liposomes. Liposomes increased in size from 5.22 ± 0.03 μm to 9.71 ± 1.11 μm with accelerated stability and large aggregates were observed. A notable difference in stability testing of Pheroid™ vesicles was seen with no significant increase in size. Entrapment efficacy of 68.72 ± 0.04% (5 °C), 67.45 ± 2.92% (25 °C) and 67.45 ± 2.92% (30 °C) were obtained at the different storage conditions. With these findings the mefloquine loaded Pheroid™ vesicles are stable and should be used investigated for the possible increase in efficacy and bioavailability and decrease toxicity. Stability data is used to determine the change the product has undergone over a certain time period at specific temperatures. In the present study, the physical stability characterized by size, pH and entrapment efficacy of mefloquine loaded liposomes and Pheroid™ vesicles were investigated. Size was accurately determined by flow cytometry. Entrapment efficacy, after unentrapped drug was removed was successfully determined by UV-spectrophotometry. The formulations contained 0.5% (m/v) mefloquine and results showed that mefloquine interfered with the formation of lipid bilayer of the liposomes. Liposomes increased in size from 5.22±0.03 μm to 9.71±1.11 μm with accelerated stability and large aggregates were observed. A notable difference in stability testing of Pheroid™ vesicles was seen with no significant increase in size. Entrapment efficacy of 68.72±0.04% (5°C), 67.45±2.92% (25°C) and 67.45±2.92% (30°C) were obtained at the different storage conditions. With these findings the mefloquine loaded Pheroid™ vesicles are stable and should be used investigated for the possible increase in efficacy and bioavailability and decrease toxicity.Stability data is used to determine the change the product has undergone over a certain time period at specific temperatures. In the present study, the physical stability characterized by size, pH and entrapment efficacy of mefloquine loaded liposomes and Pheroid™ vesicles were investigated. Size was accurately determined by flow cytometry. Entrapment efficacy, after unentrapped drug was removed was successfully determined by UV-spectrophotometry. The formulations contained 0.5% (m/v) mefloquine and results showed that mefloquine interfered with the formation of lipid bilayer of the liposomes. Liposomes increased in size from 5.22±0.03 μm to 9.71±1.11 μm with accelerated stability and large aggregates were observed. A notable difference in stability testing of Pheroid™ vesicles was seen with no significant increase in size. Entrapment efficacy of 68.72±0.04% (5°C), 67.45±2.92% (25°C) and 67.45±2.92% (30°C) were obtained at the different storage conditions. With these findings the mefloquine loaded Pheroid™ vesicles are stable and should be used investigated for the possible increase in efficacy and bioavailability and decrease toxicity. Stability data is used to determine the change the product has undergone over a certain time period at specific temperatures. In the present study, the physical stability characterized by size, pH and entrapment efficacy of mefloquine loaded liposomes and Pheroid™ vesicles were investigated. Size was accurately determined by flow cytometry. Entrapment efficacy, after unentrapped drug was removed was successfully determined by UV-spectrophotometry. The formulations contained 0.5% (m/v) mefloquine and results showed that mefloquine interfered with the formation of lipid bilayer of the liposomes. Liposomes increased in size from 5.22±0.03 μm to 9.71±1.11 μm with accelerated stability and large aggregates were observed. A notable difference in stability testing of Pheroid™ vesicles was seen with no significant increase in size. Entrapment efficacy of 68.72±0.04% (5°C), 67.45±2.92% (25°C) and 67.45±2.92% (30°C) were obtained at the different storage conditions. With these findings the mefloquine loaded Pheroid™ vesicles are stable and should be used investigated for the possible increase in efficacy and bioavailability and decrease toxicity.
Author	Kotzé, A.F. Slabbert, C. Plessis, L.H. du
Author_xml	– sequence: 1 givenname: C. surname: Slabbert fullname: Slabbert, C. – sequence: 2 givenname: L.H. du surname: Plessis fullname: Plessis, L.H. du email: Lissinda.DuPlessis@nwu.ac.za – sequence: 3 givenname: A.F. surname: Kotzé fullname: Kotzé, A.F.
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24108072$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/21310223$$D View this record in MEDLINE/PubMed
BookMark	eNqFkktvEzEQxy1URNPCRwB8QXBJGNu76416QKgqD6kSB-jZ8trjxNG-anuD8u1xHhUSByKNxpff-P-fxxW56IceCXnNYMGAVR83C78Z1zp0Cw6MLSBHCc_IjNVSzEUhqwsyAyHrecmkuCRXMW4AoOJMvCCXOTPgXMxIe7fV7aSTH3o6OJrWSMf1LnqjWzqGYcSQPEaqe0tj0o1vfdodwN8Dbf3oLbVhWlGLrd9i2NG4iwm7SM3QJ-17369oh64dHiff40vy3Ok24qvTe00evtz9uv02v__x9fvt5_u5KeoizZ1tyqK00oqls7xuICfQy7pwRuimrqxmDHSBzpYNcLvkgMAlN9xAhdJxcU3eH__NHTxOGJPqfDTYtrrHYYqqrrhccgllJj_8l2SVrEsJheTnUWByWQshIKNvTujUdGjVGHynw049jT0D706AjnnSLuje-PiXKxjUcNC8OXImDDEGdMr4dFhWCtq3WXMvW6mNOh2D2h-Dghzl3kb5T_WTwLm6t8c6pwelVyE7e_iZgRKAZWvVnvh0JDBvcesxqGg89gatD2iSsoM_o_EHEBTbFw
CODEN	IJPHDE
CitedBy_id	crossref_primary_10_3390_pharmaceutics16070897 crossref_primary_10_1016_j_actatropica_2019_04_020 crossref_primary_10_1111_jphp_12147 crossref_primary_10_1016_j_ijpharm_2015_08_014 crossref_primary_10_1016_j_jpba_2019_113044 crossref_primary_10_1517_17425255_2014_885503 crossref_primary_10_1016_j_ijpharm_2016_03_055 crossref_primary_10_1186_s40538_018_0138_8 crossref_primary_10_3109_01480545_2013_834356 crossref_primary_10_1038_ja_2012_89 crossref_primary_10_1007_s10853_016_0602_4 crossref_primary_10_1016_j_cis_2013_10_014 crossref_primary_10_1016_j_ejpb_2015_10_001
Cites_doi	10.3109/03639047909055681 10.1128/AAC.21.4.581 10.1002/(SICI)1097-0320(20000201)39:2<166::AID-CYTO10>3.0.CO;2-M 10.1016/j.ejpb.2007.08.001 10.1016/0378-5173(94)90157-0 10.1111/j.2042-7158.1998.tb03337.x 10.1016/S0378-5173(97)00135-X 10.1016/0003-2697(78)90172-0 10.1128/AAC.50.3.1045-1053.2006 10.1016/S0731-7085(02)00678-7 10.1186/1475-2875-2-14 10.1263/jbb.102.171 10.1016/0958-1669(95)80115-4 10.1016/j.ijpharm.2008.05.010 10.1186/1475-2875-9-43 10.1016/j.ijpharm.2009.10.031 10.1016/j.ijpharm.2007.09.040 10.1016/S0001-706X(01)00210-8 10.1016/S0168-3659(03)00159-7 10.1007/s00508-010-1317-1 10.1016/S0731-7085(01)00635-5 10.1016/0022-1759(89)90390-6 10.1016/j.ijpharm.2008.07.032 10.1016/j.ijpharm.2005.03.033 10.2165/00003088-199019040-00002 10.1016/S0378-5173(98)00182-3 10.1016/j.ijpharm.2008.06.012 10.1016/S0378-5173(00)00338-0 10.1016/j.addr.2007.04.009 10.1016/j.ijpharm.2005.12.019
ContentType	Journal Article
Copyright	2011 Elsevier B.V. 2015 INIST-CNRS Copyright © 2011 Elsevier B.V. All rights reserved.
Copyright_xml	– notice: 2011 Elsevier B.V. – notice: 2015 INIST-CNRS – notice: Copyright © 2011 Elsevier B.V. All rights reserved.
DBID	FBQ AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7QO 8FD FR3 P64 7S9 L.6 7X8
DOI	10.1016/j.ijpharm.2011.01.050
DatabaseName	AGRIS CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Biotechnology Research Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts AGRICOLA AGRICOLA - Academic MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Engineering Research Database Biotechnology Research Abstracts Technology Research Database Biotechnology and BioEngineering Abstracts AGRICOLA AGRICOLA - Academic MEDLINE - Academic
DatabaseTitleList	AGRICOLA Engineering Research Database MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Pharmacy, Therapeutics, & Pharmacology
EISSN	1873-3476
EndPage	215
ExternalDocumentID	21310223 24108072 10_1016_j_ijpharm_2011_01_050 US201500124160 S0378517311000810
Genre	Research Support, Non-U.S. Gov't Journal Article Comparative Study
GroupedDBID	--- --K --M .GJ .~1 0R~ 1B1 1RT 1~. 1~5 29J 3O- 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO ABFNM ABFRF ABJNI ABMAC ABOCM ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC C45 CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMT HVGLF HZ~ IHE J1W KOM M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SES SEW SPCBC SPT SSP SSZ T5K TEORI WUQ ZXP ~02 ~G- ABPIF ABPTK FBQ 9DU AATTM AAXKI AAYWO AAYXX ABWVN ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD AGCQF AGRNS BNPGV IQODW SSH CGR CUY CVF ECM EIF NPM 7QO 8FD FR3 P64 7S9 L.6 7X8
ID	FETCH-LOGICAL-c484t-fdb545d7d39fd28b0d280a984fc3ab86da110a4efd5b02d920e0272c2c06e7f23
ISICitedReferencesCount	17
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000290135800027&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0378-5173 1873-3476
IngestDate	Sun Nov 09 14:24:58 EST 2025 Sat Sep 27 23:13:40 EDT 2025 Mon Oct 06 18:04:08 EDT 2025 Mon Jul 21 05:49:43 EDT 2025 Mon Jul 21 09:17:13 EDT 2025 Sat Nov 29 01:39:51 EST 2025 Tue Nov 18 22:13:34 EST 2025 Wed Dec 27 19:26:58 EST 2023 Fri Feb 23 02:20:33 EST 2024
IsPeerReviewed	true
IsScholarly	true
Issue	1
Keywords	EE PBS MQ Liposome ICH Stability Characterization Mefloquine hydrochloride Pheroid™ Technology RH FSC CLSM Drug delivery system WHO Antimalarial Evaluation Mefloquine Stability Pharmaceutical technology Lipids Drug carrier Physical properties Characterization Parasiticide Physicochemical properties
Language	English
License	https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 Copyright © 2011 Elsevier B.V. All rights reserved.
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c484t-fdb545d7d39fd28b0d280a984fc3ab86da110a4efd5b02d920e0272c2c06e7f23
Notes	http://dx.doi.org/10.1016/j.ijpharm.2011.01.050 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
PMID	21310223
PQID	1017983330
PQPubID	23462
PageCount	7
ParticipantIDs	proquest_miscellaneous_862792705 proquest_miscellaneous_1678570472 proquest_miscellaneous_1017983330 pubmed_primary_21310223 pascalfrancis_primary_24108072 crossref_citationtrail_10_1016_j_ijpharm_2011_01_050 crossref_primary_10_1016_j_ijpharm_2011_01_050 fao_agris_US201500124160 elsevier_sciencedirect_doi_10_1016_j_ijpharm_2011_01_050
PublicationCentury	2000
PublicationDate	2011-05-16
PublicationDateYYYYMMDD	2011-05-16
PublicationDate_xml	– month: 05 year: 2011 text: 2011-05-16 day: 16
PublicationDecade	2010
PublicationPlace	Amsterdam
PublicationPlace_xml	– name: Amsterdam – name: Netherlands
PublicationTitle	International journal of pharmaceutics
PublicationTitleAlternate	Int J Pharm
PublicationYear	2011
Publisher	Elsevier B.V Elsevier
Publisher_xml	– name: Elsevier B.V – name: Elsevier
References	Stensrud, Sande, Kristensen, Smistad (bib0215) 2000; 198 Sintov, Botner (bib0205) 2006; 311 Yamabe, Kato, Onishi, Machida (bib0245) 2003; 90 Date, Joshi, Patravale (bib0060) 2007; 59 Betageri, Jenkins, Parsons (bib0025) 1993 Rhodes (bib0175) 1979; 5 Mbela, Ludwig, Landau, Deharo, Haemers (bib0140) 1994; 110 Dow, Hudson, Vahey, Koenig (bib0070) 2003; 2 Rendi-Wagner, Noedl, Wernsdorfer, Wiedermann, Mikolasek, Kollaritsch (bib0170) 2002; 81 Joshi, Pathak, Sharma, Patravale (bib0115) 2008; 362 Basco (bib0010) 2007 Congpuong, Bualombai, Banmairuroi, Na-Bangchang (bib0055) 2010; 9 Biosciences (bib0020) 2002; 2010 Chevli, Fitch (bib0040) 1982; 21 WHO, 2010b. WHO \| Malaria., 2010. WHO, 2010c. World Malaria Day 2010., 2010. Mahato (bib0130) 2007 Sharma, Sharma (bib0200) 1997; 154 Joshi, Pathak, Sharma, Patravale (bib0110) 2008; 364 New, R.R.C., 1990. Liposomes a practical approach. Sato, Obinata, Sugawara, Urabe, Yomo (bib0185) 2006; 102 WHO, 2010a. WHO \| 10 facts on malaria., 2010. Gerber, Breytenbach, du Plessis (bib0095) 2008; 351 Karbwang, White (bib0120) 1990; 19 Saunders, Davis, Coetzee, Botha, Kruger, Grobler (bib0190) 1999; 2 Vorauer-Uhl, Wagner, Borth, Katinger (bib0225) 2000; 39 Dow, Bauman, Caridha, Cabezas, Du, Gomez-Lobo, Park, Smith, Cannard (bib0065) 2006; 50 Buszello, Müller (bib0035) 2000 Mbela, Deharo, Haemers, Ludwig (bib0135) 1998; 50 Vicentini, Vaz, Fonseca, Bentley, Fonseca (bib0220) 2010 Gaumet, Vargas, Gurny, Delie (bib0090) 2008; 69 ICH, 2006. Stability testing of new drug substances and products Q1A(R2). Q1A(R2), 1–18. Fry, White, Goldman (bib0080) 1978; 90 Qiu, Jing, Jin (bib0155) 2008; 361 Arguin, Steele (bib0005) 2010 Rosenthal (bib0180) 2004 Shapiro (bib0195) 2003 Chonn, Cullis (bib0050) 1995; 6 Rao, Murthy (bib0165) 2002; 27 Bayoni, Al-Angary, Al-Meshal, Al-Dardiri (bib0015) 1998; 175 Mozafari (bib0145) 2005; 10 Maestrelli, Gonzalez-Rodriguez, Rabasco, Mura (bib0125) 2005; 298 Bouyou-Akotet, Ramharter, Ngoungou, Mamfoumbi, Mihindou, Missinou, Kurth, Belard, Agnandji, Issifou, Heidecker, Trapp, Kremsner, Kombila (bib0030) 2010; 122 Childers, Michalek, Eldridge, Denys, Berry, McGhee (bib0045) 1989; 119 Grobler, Kotze, Du Plessis (bib0100) 2007 Du Plessis, Lubbe, Strauss, Kotze (bib0075) 2010; 385 Gabriels, Plaizier-Vercammen (bib0085) 2003; 31 Ranade, Hollinger (bib0160) 2004 Slabbert, Du Plessis, Kotze (bib0210) 2010 Basco (10.1016/j.ijpharm.2011.01.050_bib0010) 2007 Karbwang (10.1016/j.ijpharm.2011.01.050_bib0120) 1990; 19 Sharma (10.1016/j.ijpharm.2011.01.050_bib0200) 1997; 154 Arguin (10.1016/j.ijpharm.2011.01.050_bib0005) 2010 Rosenthal (10.1016/j.ijpharm.2011.01.050_bib0180) 2004 Ranade (10.1016/j.ijpharm.2011.01.050_bib0160) 2004 Saunders (10.1016/j.ijpharm.2011.01.050_bib0190) 1999; 2 Grobler (10.1016/j.ijpharm.2011.01.050_bib0100) 2007 Maestrelli (10.1016/j.ijpharm.2011.01.050_bib0125) 2005; 298 Betageri (10.1016/j.ijpharm.2011.01.050_bib0025) 1993 Joshi (10.1016/j.ijpharm.2011.01.050_bib0115) 2008; 362 Buszello (10.1016/j.ijpharm.2011.01.050_bib0035) 2000 Shapiro (10.1016/j.ijpharm.2011.01.050_bib0195) 2003 Sato (10.1016/j.ijpharm.2011.01.050_bib0185) 2006; 102 Dow (10.1016/j.ijpharm.2011.01.050_bib0070) 2003; 2 Du Plessis (10.1016/j.ijpharm.2011.01.050_bib0075) 2010; 385 Rao (10.1016/j.ijpharm.2011.01.050_bib0165) 2002; 27 Slabbert (10.1016/j.ijpharm.2011.01.050_bib0210) 2010 Yamabe (10.1016/j.ijpharm.2011.01.050_bib0245) 2003; 90 Qiu (10.1016/j.ijpharm.2011.01.050_bib0155) 2008; 361 Vorauer-Uhl (10.1016/j.ijpharm.2011.01.050_bib0225) 2000; 39 Dow (10.1016/j.ijpharm.2011.01.050_bib0065) 2006; 50 Gerber (10.1016/j.ijpharm.2011.01.050_bib0095) 2008; 351 Gabriels (10.1016/j.ijpharm.2011.01.050_bib0085) 2003; 31 Mbela (10.1016/j.ijpharm.2011.01.050_bib0135) 1998; 50 Congpuong (10.1016/j.ijpharm.2011.01.050_bib0055) 2010; 9 10.1016/j.ijpharm.2011.01.050_bib0105 Sintov (10.1016/j.ijpharm.2011.01.050_bib0205) 2006; 311 Chevli (10.1016/j.ijpharm.2011.01.050_bib0040) 1982; 21 Gaumet (10.1016/j.ijpharm.2011.01.050_bib0090) 2008; 69 Chonn (10.1016/j.ijpharm.2011.01.050_bib0050) 1995; 6 10.1016/j.ijpharm.2011.01.050_bib0150 Mahato (10.1016/j.ijpharm.2011.01.050_bib0130) 2007 Date (10.1016/j.ijpharm.2011.01.050_bib0060) 2007; 59 10.1016/j.ijpharm.2011.01.050_bib0230 Vicentini (10.1016/j.ijpharm.2011.01.050_bib0220) 2010 Biosciences (10.1016/j.ijpharm.2011.01.050_bib0020) 2002; 2010 Bayoni (10.1016/j.ijpharm.2011.01.050_bib0015) 1998; 175 Fry (10.1016/j.ijpharm.2011.01.050_bib0080) 1978; 90 10.1016/j.ijpharm.2011.01.050_bib0235 Rhodes (10.1016/j.ijpharm.2011.01.050_bib0175) 1979; 5 Rendi-Wagner (10.1016/j.ijpharm.2011.01.050_bib0170) 2002; 81 Stensrud (10.1016/j.ijpharm.2011.01.050_bib0215) 2000; 198 10.1016/j.ijpharm.2011.01.050_bib0240 Bouyou-Akotet (10.1016/j.ijpharm.2011.01.050_bib0030) 2010; 122 Mbela (10.1016/j.ijpharm.2011.01.050_bib0140) 1994; 110 Mozafari (10.1016/j.ijpharm.2011.01.050_bib0145) 2005; 10 Joshi (10.1016/j.ijpharm.2011.01.050_bib0110) 2008; 364 Childers (10.1016/j.ijpharm.2011.01.050_bib0045) 1989; 119
References_xml	– volume: 27 start-page: 959 year: 2002 end-page: 965 ident: bib0165 article-title: A rapid spectrophotometric method for the determination of mefloquine hydrochloride publication-title: J. Pharm. Biomed. Anal. – volume: 198 start-page: 213 year: 2000 end-page: 228 ident: bib0215 article-title: Formulation and characterisation of primaquine loaded liposomes prepared by a pH gradient using experimental design publication-title: Int. J. Pharm. – volume: 69 start-page: 1 year: 2008 end-page: 9 ident: bib0090 article-title: Nanoparticles for drug delivery: the need for precision in reporting particle size parameters publication-title: Eur. J. Pharm. Biopharm. – volume: 21 start-page: 581 year: 1982 end-page: 586 ident: bib0040 article-title: The antimalarial drug mefloquine binds to membrane phospholipids publication-title: Antimicrob. Agents Chemother. – volume: 59 start-page: 505 year: 2007 end-page: 521 ident: bib0060 article-title: Parasitic diseases: Liposomes and polymeric nanoparticles versus lipid nanoparticles publication-title: Adv. Drug Deliv. Rev. – volume: 385 start-page: 181 year: 2010 end-page: 186 ident: bib0075 article-title: Enhancement of nasal and intestinal calcitonin delivery by the novel Pheroid™ fatty acid based delivery system, and by N-trimethyl chitosan chloride publication-title: Int. J. Pharm. – volume: 2 start-page: 14 year: 2003 ident: bib0070 article-title: The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function publication-title: Malar J. – volume: 90 start-page: 809 year: 1978 end-page: 815 ident: bib0080 article-title: Rapid separation of low molecular weight solutes from liposomes without dilution publication-title: Anal. Biochem. – volume: 364 start-page: 119 year: 2008 end-page: 126 ident: bib0110 article-title: Design and publication-title: Int. J. Pharm. – volume: 311 start-page: 55 year: 2006 end-page: 62 ident: bib0205 article-title: Transdermal drug delivery using microemulsion and aqueous systems: Influence of skin storage conditions on the publication-title: Int. J. Pharm. – volume: 362 start-page: 172 year: 2008 end-page: 178 ident: bib0115 article-title: Solid microemulsion preconcentrate (NanOsorb) of artemether for effective treatment of malaria publication-title: Int. J. Pharm. – start-page: 864 year: 2004 end-page: 885 ident: bib0180 article-title: Antiprotozoal drugs publication-title: Basic & Clinical Pharmacology – volume: 351 start-page: 186 year: 2008 end-page: 193 ident: bib0095 article-title: Transdermal penetration of zalcitabine, lamivudine and synthesised N-acyl lamivudine esters publication-title: Int. J. Pharm. – volume: 81 start-page: 167 year: 2002 end-page: 173 ident: bib0170 article-title: Unexpected frequency, duration and spectrum of adverse events after therapeutic dose of mefloquine in healthy adults publication-title: Acta Trop. – reference: New, R.R.C., 1990. Liposomes a practical approach. – year: 2007 ident: bib0010 article-title: Field Application of – volume: 361 start-page: 56 year: 2008 end-page: 63 ident: bib0155 article-title: Preparation and publication-title: Int. J. Pharm. – reference: WHO, 2010b. WHO \| Malaria., 2010. – year: 1993 ident: bib0025 article-title: Liposome Drug Delivery System – volume: 50 start-page: 1045 year: 2006 end-page: 1053 ident: bib0065 article-title: Mefloquine induces dose-related neurological effects in a rat model publication-title: Antimicrob. Agents Chemother. – volume: 119 start-page: 135 year: 1989 end-page: 143 ident: bib0045 article-title: Characterization of liposome suspensions by flow cytometry publication-title: J. Immunol. Methods – volume: 122 start-page: 173 year: 2010 end-page: 178 ident: bib0030 article-title: Efficacy and safety of a new pediatric artesunate-mefloquine drug formulation for the treatment of uncomplicated falciparum malaria in Gabon publication-title: Wien. Klin. Wochenschr. – volume: 31 start-page: 655 year: 2003 end-page: 667 ident: bib0085 article-title: Physical and chemical evaluation of liposomes, containing artesunate publication-title: J. Pharm. Biomed. Anal. – volume: 10 start-page: 711 year: 2005 end-page: 719 ident: bib0145 article-title: Liposomes: an overview of manufacturing techniques publication-title: Cell. Mol. Biol. Lett. – start-page: 191 year: 2000 end-page: 228 ident: bib0035 article-title: Emulsions as drug delivery systems publication-title: Pharmaceutical Emulsions and Suspensions – volume: 2010 start-page: 50 year: 2002 ident: bib0020 article-title: Introduction to Flow Cytometry publication-title: Learning Guide – reference: WHO, 2010a. WHO \| 10 facts on malaria., 2010. – year: 2004 ident: bib0160 article-title: Drug Delivery Systems – year: 2010 ident: bib0005 article-title: Chapter 2 – Malaria – 2010 Yellow Book \| CDC publication-title: Traveler's Health – volume: 102 start-page: 171 year: 2006 end-page: 178 ident: bib0185 article-title: Quantification of structural properties of cell-sized individual liposomes by flow cytometry publication-title: J. Biosci. Bioeng. – volume: 2 start-page: 99 year: 1999 end-page: 107 ident: bib0190 article-title: A novel skin penetration enhancer: evaluation by membrane diffusion and confocal microscopy publication-title: J. Pharm. Pharm. Sci. – year: 2010 ident: bib0210 article-title: 7th World meeting of pharmaceutics publication-title: Biopharmaceutics and Pharmaceutical Technology – volume: 175 start-page: 1 year: 1998 end-page: 7 ident: bib0015 publication-title: Int. J. Pharm. – volume: 5 start-page: 573 year: 1979 end-page: 587 ident: bib0175 article-title: Physical stability of pharmaceutical products publication-title: Drug Dev. Ind. Pharm. – start-page: 491078 year: 2010 ident: bib0220 article-title: Characterization and stability study of a water-in-oil microemulsion incorporating quercetin publication-title: Drug Dev. Ind. Pharm – reference: ICH, 2006. Stability testing of new drug substances and products Q1A(R2). Q1A(R2), 1–18. – volume: 50 start-page: 1221 year: 1998 end-page: 1225 ident: bib0135 article-title: Submicron oil-in-water emulsion formulations for mefloquine and halofantrine: effect of electric-charge inducers on antimalarial activity in mice publication-title: J. Pharm. Pharmacol. – volume: 6 start-page: 698 year: 1995 end-page: 708 ident: bib0050 article-title: Recent advances in liposomal drug-delivery systems publication-title: Curr. Opin. Biotechnol. – year: 2007 ident: bib0130 article-title: Pharmaceutical Dosage Forms and Drug Delivery – volume: 90 start-page: 71 year: 2003 end-page: 79 ident: bib0245 publication-title: J. Control Rel. – volume: 298 start-page: 55 year: 2005 end-page: 67 ident: bib0125 article-title: Preparation and characterisation of liposomes encapsulating ketoprofen-cyclodextrin complexes for transdermal drug delivery publication-title: Int. J. Pharm. – volume: 39 start-page: 166 year: 2000 end-page: 171 ident: bib0225 article-title: Determination of liposome size distribution by flow cytometry publication-title: Cytometry – volume: 9 start-page: 43 year: 2010 ident: bib0055 article-title: Compliance with a three-day course of artesunate-mefloquine combination and baseline anti-malarial treatment in an area of Thailand with highly multidrug resistant falciparum malaria publication-title: Malar J. – volume: 19 start-page: 264 year: 1990 end-page: 279 ident: bib0120 article-title: Clinical pharmacokinetics of mefloquine publication-title: Clin. Pharmacokinet. – volume: 154 start-page: 123 year: 1997 end-page: 140 ident: bib0200 article-title: Liposomes in drug delivery: Progress and limitations publication-title: Int. J. Pharm. – year: 2003 ident: bib0195 article-title: Practical Flow Cytometry – reference: WHO, 2010c. World Malaria Day 2010., 2010. – volume: 110 start-page: 189 year: 1994 end-page: 196 ident: bib0140 article-title: Preparation, characterization and in vivo activity of mefloquine submicron emulsions publication-title: Int. J. Pharm. – year: 2007 ident: bib0100 article-title: The design of a skin friendly carrier for cosmetic compounds using Pheroid™ technology publication-title: Delivery Systems Technologies – start-page: 191 year: 2000 ident: 10.1016/j.ijpharm.2011.01.050_bib0035 article-title: Emulsions as drug delivery systems – volume: 5 start-page: 573 year: 1979 ident: 10.1016/j.ijpharm.2011.01.050_bib0175 article-title: Physical stability of pharmaceutical products publication-title: Drug Dev. Ind. Pharm. doi: 10.3109/03639047909055681 – volume: 21 start-page: 581 year: 1982 ident: 10.1016/j.ijpharm.2011.01.050_bib0040 article-title: The antimalarial drug mefloquine binds to membrane phospholipids publication-title: Antimicrob. Agents Chemother. doi: 10.1128/AAC.21.4.581 – year: 2007 ident: 10.1016/j.ijpharm.2011.01.050_bib0100 article-title: The design of a skin friendly carrier for cosmetic compounds using Pheroid™ technology – year: 2010 ident: 10.1016/j.ijpharm.2011.01.050_bib0005 article-title: Chapter 2 – Malaria – 2010 Yellow Book \| CDC publication-title: Traveler's Health – ident: 10.1016/j.ijpharm.2011.01.050_bib0240 – volume: 39 start-page: 166 year: 2000 ident: 10.1016/j.ijpharm.2011.01.050_bib0225 article-title: Determination of liposome size distribution by flow cytometry publication-title: Cytometry doi: 10.1002/(SICI)1097-0320(20000201)39:2<166::AID-CYTO10>3.0.CO;2-M – ident: 10.1016/j.ijpharm.2011.01.050_bib0230 – volume: 69 start-page: 1 year: 2008 ident: 10.1016/j.ijpharm.2011.01.050_bib0090 article-title: Nanoparticles for drug delivery: the need for precision in reporting particle size parameters publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2007.08.001 – volume: 110 start-page: 189 year: 1994 ident: 10.1016/j.ijpharm.2011.01.050_bib0140 article-title: Preparation, characterization and in vivo activity of mefloquine submicron emulsions publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(94)90157-0 – year: 2010 ident: 10.1016/j.ijpharm.2011.01.050_bib0210 article-title: 7th World meeting of pharmaceutics – year: 2007 ident: 10.1016/j.ijpharm.2011.01.050_bib0130 – year: 2007 ident: 10.1016/j.ijpharm.2011.01.050_bib0010 – ident: 10.1016/j.ijpharm.2011.01.050_bib0150 – volume: 2010 start-page: 50 year: 2002 ident: 10.1016/j.ijpharm.2011.01.050_bib0020 article-title: Introduction to Flow Cytometry publication-title: Learning Guide – volume: 50 start-page: 1221 year: 1998 ident: 10.1016/j.ijpharm.2011.01.050_bib0135 article-title: Submicron oil-in-water emulsion formulations for mefloquine and halofantrine: effect of electric-charge inducers on antimalarial activity in mice publication-title: J. Pharm. Pharmacol. doi: 10.1111/j.2042-7158.1998.tb03337.x – volume: 154 start-page: 123 year: 1997 ident: 10.1016/j.ijpharm.2011.01.050_bib0200 article-title: Liposomes in drug delivery: Progress and limitations publication-title: Int. J. Pharm. doi: 10.1016/S0378-5173(97)00135-X – start-page: 491078 year: 2010 ident: 10.1016/j.ijpharm.2011.01.050_bib0220 article-title: Characterization and stability study of a water-in-oil microemulsion incorporating quercetin publication-title: Drug Dev. Ind. Pharm – volume: 90 start-page: 809 year: 1978 ident: 10.1016/j.ijpharm.2011.01.050_bib0080 article-title: Rapid separation of low molecular weight solutes from liposomes without dilution publication-title: Anal. Biochem. doi: 10.1016/0003-2697(78)90172-0 – volume: 50 start-page: 1045 year: 2006 ident: 10.1016/j.ijpharm.2011.01.050_bib0065 article-title: Mefloquine induces dose-related neurological effects in a rat model publication-title: Antimicrob. Agents Chemother. doi: 10.1128/AAC.50.3.1045-1053.2006 – volume: 31 start-page: 655 year: 2003 ident: 10.1016/j.ijpharm.2011.01.050_bib0085 article-title: Physical and chemical evaluation of liposomes, containing artesunate publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/S0731-7085(02)00678-7 – volume: 2 start-page: 14 year: 2003 ident: 10.1016/j.ijpharm.2011.01.050_bib0070 article-title: The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro publication-title: Malar J. doi: 10.1186/1475-2875-2-14 – volume: 102 start-page: 171 year: 2006 ident: 10.1016/j.ijpharm.2011.01.050_bib0185 article-title: Quantification of structural properties of cell-sized individual liposomes by flow cytometry publication-title: J. Biosci. Bioeng. doi: 10.1263/jbb.102.171 – year: 2004 ident: 10.1016/j.ijpharm.2011.01.050_bib0160 – volume: 6 start-page: 698 year: 1995 ident: 10.1016/j.ijpharm.2011.01.050_bib0050 article-title: Recent advances in liposomal drug-delivery systems publication-title: Curr. Opin. Biotechnol. doi: 10.1016/0958-1669(95)80115-4 – volume: 361 start-page: 56 year: 2008 ident: 10.1016/j.ijpharm.2011.01.050_bib0155 article-title: Preparation and in vitro evaluation of liposomal chloroquine diphosphate loaded by a transmembrane pH-gradient method publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2008.05.010 – volume: 2 start-page: 99 year: 1999 ident: 10.1016/j.ijpharm.2011.01.050_bib0190 article-title: A novel skin penetration enhancer: evaluation by membrane diffusion and confocal microscopy publication-title: J. Pharm. Pharm. Sci. – volume: 9 start-page: 43 year: 2010 ident: 10.1016/j.ijpharm.2011.01.050_bib0055 article-title: Compliance with a three-day course of artesunate-mefloquine combination and baseline anti-malarial treatment in an area of Thailand with highly multidrug resistant falciparum malaria publication-title: Malar J. doi: 10.1186/1475-2875-9-43 – year: 1993 ident: 10.1016/j.ijpharm.2011.01.050_bib0025 – volume: 385 start-page: 181 year: 2010 ident: 10.1016/j.ijpharm.2011.01.050_bib0075 article-title: Enhancement of nasal and intestinal calcitonin delivery by the novel Pheroid™ fatty acid based delivery system, and by N-trimethyl chitosan chloride publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2009.10.031 – volume: 351 start-page: 186 year: 2008 ident: 10.1016/j.ijpharm.2011.01.050_bib0095 article-title: Transdermal penetration of zalcitabine, lamivudine and synthesised N-acyl lamivudine esters publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2007.09.040 – volume: 10 start-page: 711 year: 2005 ident: 10.1016/j.ijpharm.2011.01.050_bib0145 article-title: Liposomes: an overview of manufacturing techniques publication-title: Cell. Mol. Biol. Lett. – volume: 81 start-page: 167 year: 2002 ident: 10.1016/j.ijpharm.2011.01.050_bib0170 article-title: Unexpected frequency, duration and spectrum of adverse events after therapeutic dose of mefloquine in healthy adults publication-title: Acta Trop. doi: 10.1016/S0001-706X(01)00210-8 – volume: 90 start-page: 71 year: 2003 ident: 10.1016/j.ijpharm.2011.01.050_bib0245 article-title: In vitro characteristics of liposomes and double liposomes prepared using a novel glass beads method publication-title: J. Control Rel. doi: 10.1016/S0168-3659(03)00159-7 – volume: 122 start-page: 173 year: 2010 ident: 10.1016/j.ijpharm.2011.01.050_bib0030 article-title: Efficacy and safety of a new pediatric artesunate-mefloquine drug formulation for the treatment of uncomplicated falciparum malaria in Gabon publication-title: Wien. Klin. Wochenschr. doi: 10.1007/s00508-010-1317-1 – volume: 27 start-page: 959 year: 2002 ident: 10.1016/j.ijpharm.2011.01.050_bib0165 article-title: A rapid spectrophotometric method for the determination of mefloquine hydrochloride publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/S0731-7085(01)00635-5 – volume: 119 start-page: 135 year: 1989 ident: 10.1016/j.ijpharm.2011.01.050_bib0045 article-title: Characterization of liposome suspensions by flow cytometry publication-title: J. Immunol. Methods doi: 10.1016/0022-1759(89)90390-6 – volume: 364 start-page: 119 year: 2008 ident: 10.1016/j.ijpharm.2011.01.050_bib0110 article-title: Design and in vivo pharmacodynamic evaluation of nanostructured lipid carriers for parenteral delivery of artemether: Nanoject publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2008.07.032 – start-page: 864 year: 2004 ident: 10.1016/j.ijpharm.2011.01.050_bib0180 article-title: Antiprotozoal drugs – volume: 298 start-page: 55 year: 2005 ident: 10.1016/j.ijpharm.2011.01.050_bib0125 article-title: Preparation and characterisation of liposomes encapsulating ketoprofen-cyclodextrin complexes for transdermal drug delivery publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2005.03.033 – year: 2003 ident: 10.1016/j.ijpharm.2011.01.050_bib0195 – ident: 10.1016/j.ijpharm.2011.01.050_bib0235 – ident: 10.1016/j.ijpharm.2011.01.050_bib0105 – volume: 19 start-page: 264 year: 1990 ident: 10.1016/j.ijpharm.2011.01.050_bib0120 article-title: Clinical pharmacokinetics of mefloquine publication-title: Clin. Pharmacokinet. doi: 10.2165/00003088-199019040-00002 – volume: 175 start-page: 1 year: 1998 ident: 10.1016/j.ijpharm.2011.01.050_bib0015 article-title: In vivo evaluation of arteether liposomes publication-title: Int. J. Pharm. doi: 10.1016/S0378-5173(98)00182-3 – volume: 362 start-page: 172 year: 2008 ident: 10.1016/j.ijpharm.2011.01.050_bib0115 article-title: Solid microemulsion preconcentrate (NanOsorb) of artemether for effective treatment of malaria publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2008.06.012 – volume: 198 start-page: 213 year: 2000 ident: 10.1016/j.ijpharm.2011.01.050_bib0215 article-title: Formulation and characterisation of primaquine loaded liposomes prepared by a pH gradient using experimental design publication-title: Int. J. Pharm. doi: 10.1016/S0378-5173(00)00338-0 – volume: 59 start-page: 505 year: 2007 ident: 10.1016/j.ijpharm.2011.01.050_bib0060 article-title: Parasitic diseases: Liposomes and polymeric nanoparticles versus lipid nanoparticles publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2007.04.009 – volume: 311 start-page: 55 year: 2006 ident: 10.1016/j.ijpharm.2011.01.050_bib0205 article-title: Transdermal drug delivery using microemulsion and aqueous systems: Influence of skin storage conditions on the in vitro permeability of diclofenac from aqueous vehicle systems publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2005.12.019
SSID	ssj0006213
Score	2.094098
Snippet	Stability data is used to determine the change the product has undergone over a certain time period at specific temperatures. In the present study, the...
SourceID	proquest pubmed pascalfrancis crossref fao elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	209
SubjectTerms	Antimalarials - administration & dosage Antimalarials - chemistry Bioavailability Biological and medical sciences Colloids Data processing Drug delivery Drug delivery system Drug Delivery Systems Drug Stability Drug Storage drugs Fatty Acids - chemistry Flow Cytometry General pharmacology Hydrogen-Ion Concentration Lipid bilayers Liposome Liposomes Medical sciences Mefloquine Mefloquine - administration & dosage Mefloquine - chemistry Mefloquine hydrochloride Particle Size pH effects Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pheroid™ Technology Spectrophotometry, Ultraviolet Stability Characterization Storage conditions Temperature Temperature effects Toxicity Vesicles
Title	Evaluation of the physical properties and stability of two lipid drug delivery systems containing mefloquine
URI	https://dx.doi.org/10.1016/j.ijpharm.2011.01.050 https://www.ncbi.nlm.nih.gov/pubmed/21310223 https://www.proquest.com/docview/1017983330 https://www.proquest.com/docview/1678570472 https://www.proquest.com/docview/862792705
Volume	409
WOSCitedRecordID	wos000290135800027&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1873-3476 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0006213 issn: 0378-5173 databaseCode: AIEXJ dateStart: 19950102 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Za9swGBc99rCXsbvZUTQYfUnd2fIh-bGMlB0hCzSBvAlZsrsEL_Zy9Njz_vB9smWrhWbtHgZGBEty5Hy_fPr0nQi9F1KGQZQQR-_dTpAQ4SSepxwJ4gFjoXBDkVTFJuhgwCaTeLi19buJhTnP6XzOLi_j8r-SGu4BsXXo7D-Qu30o3IDPQHRogezQ3ovwvTZ_d2P_LxtalFrzvtApVCubAQiGlWtsZWRfXRTdfFpOVVct1mddlebaY-PKpHpeVj7tdTWJ7o80y2E_aSzyM-sMb3WL1zJSlN-t2ryV4E8BfYmJF7LlktfdYa79citw9Vsr1tdi9atWvBpHZGX1rqFTR1E24VlwXA29um5Jw3oDN76OMRMIaVip6UsNYw1vZfi17mF2NJ1VL2NyssJVp7O9mWB78I2fjPt9PupNRgflT0fXHtM2elOIZRvtEhrGwN53jz_3Jl_aHT0ipsy2eQUbCfbh1m_eJONsZ6LQzrdiCTTP6sIpm082lYQzeowemaMJPq4h9QRtpfOn6GBYU-_qEI9sqN7yEB_goc16fvUM5RZ3uMgw4A43uMMWdxhwh1vcVQMvClzhDmvc4QZ32OAOW9xhi7vnaHzSG3385JhSHo4MWLByMpWAqK6o8uNMEZa40LgiZkEmfZGwSAkQQ0WQZipMXKJi4qYuoUQS6UYpzYj_Au3Mi3m6h3CSpYJKL8koZYH0CZNeFNLYS6WKfJDJOihofnwuTZ57XW4l541D44wbmnFNM-7CFboddNROK-tEL3dNYA1luZFWaymUAzbvmroHSODiDPZxPj4lWusIgiKcjaBr_wY82rVALxzuKOmgdw1eOOwE2rwn5mmxXvJqc2W-77t_GQOyaUh1htgOwhvGsEgnFaVu2EEvazzaRXi-1hD5r-6xiNfooeUDb9DOarFO36IH8nw1XS720TadsH3zR_sDn6r7cA
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evaluation+of+the+physical+properties+and+stability+of+two+lipid+drug+delivery+systems+containing+mefloquine&rft.jtitle=International+journal+of+pharmaceutics&rft.au=Slabbert%2C+C&rft.au=Du+Plessis%2C+LH&rft.au=Kotze%2C+A+F&rft.date=2011-05-16&rft.issn=0378-5173&rft.volume=409&rft.issue=1-2&rft.spage=209&rft.epage=215&rft_id=info:doi/10.1016%2Fj.ijpharm.2011.01.050&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0378-5173&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0378-5173&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0378-5173&client=summon