Comparing the reprogramming efficiency of mouse embryonic fibroblasts, mouse bone marrow mesenchymal stem cells and bone marrow mononuclear cells to iPSCs

Induced pluripotent stem cells have been derived from various cell types via the ectopic expression of a cocktail of transcription factors. Previous studies have reported that induced pluripotent stem cells can be differentiated into multiple somatic cells, providing an invaluable resource in regene...

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Published in:	In vitro cellular & developmental biology. Animal Vol. 48; no. 4; pp. 236 - 243
Main Authors:	Wang, Lei, Zhu, Mingyan, Guo, Qingsong, Fan, Xiangjun, Lu, Yuhua, Zhu, Shajun, Wang, Yao, Huang, Yan, Wang, Zhiwei
Format:	Journal Article
Language:	English
Published:	New York Springer-Verlag 01.04.2012 Springer Science + Business Media Society for In Vitro Biology
Subjects:	Alkaline phosphatase Animal Genetics and Genomics Animals Antigens, CD Antigens, CD - metabolism Biomedical and Life Sciences Blood cells Bone marrow Bone marrow cells Bone Marrow Cells - cytology Bone Marrow Cells - metabolism CELL AND TISSUE MODELS Cell Biology Cell Culture Cell Culture Techniques Cell Differentiation Cellular Reprogramming clones cytology Developmental Biology Embryo cells Embryo fibroblasts Embryonic stem cells Enumeration Feeder cells fibroblasts Fibroblasts - cytology Induced pluripotent stem cells Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Inhibitory postsynaptic potentials Leukocytes (mononuclear) Life Sciences medicine Mesenchymal Stem Cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mesenchyme metabolism Mice Pluripotent Stem Cells Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Regeneration Somatic cells Stem Cells T lymphocytes teratoma Transcription factors iPSCs BM MNCs Pluripotency BMSCs Reprogramming efficiency
ISSN:	1071-2690, 1543-706X, 1543-706X
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Abstract	Induced pluripotent stem cells have been derived from various cell types via the ectopic expression of a cocktail of transcription factors. Previous studies have reported that induced pluripotent stem cells can be differentiated into multiple somatic cells, providing an invaluable resource in regenerative medicine. In this study, we compared the reprogramming efficiency of mouse embryonic fibroblasts, mouse bone marrow mesenchymal stem cells, and mouse bone marrow mononuclear cells by counting the number of alkaline phosphatase staining positive clones on day 15 after induced pluripotent stem cells induction. We found that a very low number of alkaline phosphatase-staining positive clones were derived from mouse bone marrow mesenchymal stem cells. We then evaluated the pluripotency of the clones by detecting the expression of embryonic stem cells markers and assessing their ability to form embryoid bodies and teratomas. Mouse bone marrow mesenchymal stem cells population is more homogeneous than mouse bone marrow mononuclear cells, which includes a variety of cell types. Our study indicated that the extremely low efficiency of mouse bone marrow mesenchymal stem cells induction implies that mouse bone marrow mesenchymal stem cells may not be a suitable cell type for the induction of induced pluripotent stem cells unless the efficiency of induction can be improved.
AbstractList	Induced pluripotent stem cells have been derived from various cell types via the ectopic expression of a cocktail of transcription factors. Previous studies have reported that induced pluripotent stem cells can be differentiated into multiple somatic cells, providing an invaluable resource in regenerative medicine. In this study, we compared the reprogramming efficiency of mouse embryonic fibroblasts, mouse bone marrow mesenchymal stem cells, and mouse bone marrow mononuclear cells by counting the number of alkaline phosphatase staining positive clones on day 15 after induced pluripotent stem cells induction. We found that a very low number of alkaline phosphatase-staining positive clones were derived from mouse bone marrow mesenchymal stem cells. We then evaluated the pluripotency of the clones by detecting the expression of embryonic stem cells markers and assessing their ability to form embryoid bodies and teratomas. Mouse bone marrow mesenchymal stem cells population is more homogeneous than mouse bone marrow mononuclear cells, which includes a variety of cell types. Our study indicated that the extremely low efficiency of mouse bone marrow mesenchymal stem cells induction implies that mouse bone marrow mesenchymal stem cells may not be a suitable cell type for the induction of induced pluripotent stem cells unless the efficiency of induction can be improved. Induced pluripotent stem cells have been derived from various cell types via the ectopic expression of a cocktail of transcription factors. Previous studies have reported that induced pluripotent stem cells can be differentiated into multiple somatic cells, providing an invaluable resource in regenerative medicine. In this study, we compared the reprogramming efficiency of mouse embryonic fibroblasts, mouse bone marrow mesenchymal stem cells, and mouse bone marrow mononuclear cells by counting the number of alkaline phosphatase staining positive clones on day 15 after induced pluripotent stem cells induction. We found that a very low number of alkaline phosphatasestaining positive clones were derived from mouse bone marrow mesenchymal stem cells. We then evaluated the pluripotency of the clones by detecting the expression of embryonic stem cells markers and assessing their ability to form embryoid bodies and teratomas. Mouse bone marrow mesenchymal stem cells population is more homogeneous than mouse bone marrow mononuclear cells, which includes a variety of cell types. Our study indicated that the extremely low efficiency of mouse bone marrow mesenchymal stem cells induction implies that mouse bone marrow mesenchymal stem cells may not be a suitable cell type for the induction of induced pluripotent stem cells unless the efficiency of induction can be improved. Induced pluripotent stem cells have been derived from various cell types via the ectopic expression of a cocktail of transcription factors. Previous studies have reported that induced pluripotent stem cells can be differentiated into multiple somatic cells, providing an invaluable resource in regenerative medicine. In this study, we compared the reprogramming efficiency of mouse embryonic fibroblasts, mouse bone marrow mesenchymal stem cells, and mouse bone marrow mononuclear cells by counting the number of alkaline phosphatase staining positive clones on day 15 after induced pluripotent stem cells induction. We found that a very low number of alkaline phosphatase-staining positive clones were derived from mouse bone marrow mesenchymal stem cells. We then evaluated the pluripotency of the clones by detecting the expression of embryonic stem cells markers and assessing their ability to form embryoid bodies and teratomas. Mouse bone marrow mesenchymal stem cells population is more homogeneous than mouse bone marrow mononuclear cells, which includes a variety of cell types. Our study indicated that the extremely low efficiency of mouse bone marrow mesenchymal stem cells induction implies that mouse bone marrow mesenchymal stem cells may not be a suitable cell type for the induction of induced pluripotent stem cells unless the efficiency of induction can be improved. Induced pluripotent stem cells have been derived from various cell types via the ectopic expression of a cocktail of transcription factors. Previous studies have reported that induced pluripotent stem cells can be differentiated into multiple somatic cells, providing an invaluable resource in regenerative medicine. In this study, we compared the reprogramming efficiency of mouse embryonic fibroblasts, mouse bone marrow mesenchymal stem cells, and mouse bone marrow mononuclear cells by counting the number of alkaline phosphatase staining positive clones on day 15 after induced pluripotent stem cells induction. We found that a very low number of alkaline phosphatase-staining positive clones were derived from mouse bone marrow mesenchymal stem cells. We then evaluated the pluripotency of the clones by detecting the expression of embryonic stem cells markers and assessing their ability to form embryoid bodies and teratomas. Mouse bone marrow mesenchymal stem cells population is more homogeneous than mouse bone marrow mononuclear cells, which includes a variety of cell types. Our study indicated that the extremely low efficiency of mouse bone marrow mesenchymal stem cells induction implies that mouse bone marrow mesenchymal stem cells may not be a suitable cell type for the induction of induced pluripotent stem cells unless the efficiency of induction can be improved.Induced pluripotent stem cells have been derived from various cell types via the ectopic expression of a cocktail of transcription factors. Previous studies have reported that induced pluripotent stem cells can be differentiated into multiple somatic cells, providing an invaluable resource in regenerative medicine. In this study, we compared the reprogramming efficiency of mouse embryonic fibroblasts, mouse bone marrow mesenchymal stem cells, and mouse bone marrow mononuclear cells by counting the number of alkaline phosphatase staining positive clones on day 15 after induced pluripotent stem cells induction. We found that a very low number of alkaline phosphatase-staining positive clones were derived from mouse bone marrow mesenchymal stem cells. We then evaluated the pluripotency of the clones by detecting the expression of embryonic stem cells markers and assessing their ability to form embryoid bodies and teratomas. Mouse bone marrow mesenchymal stem cells population is more homogeneous than mouse bone marrow mononuclear cells, which includes a variety of cell types. Our study indicated that the extremely low efficiency of mouse bone marrow mesenchymal stem cells induction implies that mouse bone marrow mesenchymal stem cells may not be a suitable cell type for the induction of induced pluripotent stem cells unless the efficiency of induction can be improved.
Author	Wang, Yao Zhu, Mingyan Huang, Yan Wang, Lei Guo, Qingsong Zhu, Shajun Fan, Xiangjun Lu, Yuhua Wang, Zhiwei
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CitedBy_id	crossref_primary_10_2478_aoas_2025_0073 crossref_primary_10_1016_j_diabres_2014_03_017 crossref_primary_10_1155_2017_4276928 crossref_primary_10_1177_0885328215587610
Cites_doi	10.1182/blood-2009-02-204800 10.1016/j.stem.2010.08.012 10.1089/scd.2009.0149 10.1016/j.cell.2008.07.041 10.1016/j.stem.2008.10.002 10.1089/scd.2010.0063 10.1038/nature08311 10.1634/stemcells.2008-0346 10.1016/j.cub.2008.05.010 10.1126/science.1154884 10.1038/nature08235 10.1016/j.stem.2011.03.001 10.1073/pnas.0904825106 10.1182/blood-2009-02-203695 10.1038/cr.2011.51 10.1002/jcb.10594 10.1016/j.cell.2006.07.024 10.1016/j.stem.2009.12.001 10.1016/j.cell.2008.03.028 10.1016/j.cell.2007.11.019 10.1007/s00268-007-9168-2 10.1634/stemcells.2008-0317 10.1038/cr.2010.26 10.1016/j.cell.2009.01.023
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Copyright	2012 Society for In Vitro Biology The Society for In Vitro Biology 2012 Copyright Society for In Vitro Biology Apr 2012
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References	Okabe, Otsu, Ahn (CR15) 2009; 114 Hanna, Markoulaki, Schorderet (CR7) 2008; 133 Park, Arora, Huo (CR17) 2008; 134 Warren, Manos, Ahfeldt (CR21) 2010; 7 Takahashi, Yamanaka (CR20) 2006; 126 Kunisato, Wakatsuki, Shinba (CR12) 2011; 20 Anokye-Danso, Trivedi, Juhr (CR1) 2011; 8 Zhao, Li, Lv (CR23) 2010; 20 Hong, Takahashi, Ichisaka (CR8) 2009; 460 Chen, Liu, Chen (CR4) 2011; 21 Stadtfeld, Brennand, Hochedlinger (CR18) 2008; 18 Eminli, Utikal, Arnold (CR5) 2008; 26 Kawamura, Suzuki, Wang (CR9) 2009; 460 Mali, Ye, Hommond (CR14) 2008; 26 Aoi, Yae, Nakagawa (CR2) 2008; 321 Takahashi, Tanabe, Ohnuki (CR19) 2007; 131 Xu, Lu, Ding (CR22) 2007; 31 Kunisato, Wakatsuki, Kodama (CR11) 2010; 19 Baddoo, Hill, Wilkinson (CR3) 2003; 89 Papapetrou, Tomishima, Chambers (CR16) 2009; 106 Esteban, Wang, Qin (CR6) 2010; 6 Loh, Agarwal, Park (CR13) 2009; 113 Zhao, Yin, Qin (CR24) 2008; 3 Kim, Sebastiano, Wu (CR10) 2009; 136 J Xu (9493_CR22) 2007; 31 M Stadtfeld (9493_CR18) 2008; 18 J Chen (9493_CR4) 2011; 21 YH Loh (9493_CR13) 2009; 113 T Aoi (9493_CR2) 2008; 321 K Takahashi (9493_CR20) 2006; 126 EP Papapetrou (9493_CR16) 2009; 106 K Takahashi (9493_CR19) 2007; 131 A Kunisato (9493_CR12) 2011; 20 M Baddoo (9493_CR3) 2003; 89 P Mali (9493_CR14) 2008; 26 H Hong (9493_CR8) 2009; 460 JB Kim (9493_CR10) 2009; 136 J Hanna (9493_CR7) 2008; 133 M Okabe (9493_CR15) 2009; 114 L Warren (9493_CR21) 2010; 7 IH Park (9493_CR17) 2008; 134 S Eminli (9493_CR5) 2008; 26 XY Zhao (9493_CR23) 2010; 20 F Anokye-Danso (9493_CR1) 2011; 8 MA Esteban (9493_CR6) 2010; 6 A Kunisato (9493_CR11) 2010; 19 T Kawamura (9493_CR9) 2009; 460 Y Zhao (9493_CR24) 2008; 3 19549847 - Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12759-64 19558219 - Stem Cells Dev. 2010 Feb;19(2):229-38 17653584 - World J Surg. 2007 Sep;31(9):1872-82 19668186 - Nature. 2009 Aug 27;460(7259):1140-4 18423197 - Cell. 2008 Apr 18;133(2):250-64 18511599 - Stem Cells. 2008 Aug;26(8):1998-2005 20036631 - Cell Stem Cell. 2010 Jan 8;6(1):71-9 18691744 - Cell. 2008 Sep 5;134(5):877-86 18501604 - Curr Biol. 2008 Jun 24;18(12):890-4 18983962 - Cell Stem Cell. 2008 Nov 6;3(5):475-9 18635867 - Stem Cells. 2008 Oct;26(10):2467-74 20157334 - Cell Res. 2010 Mar;20(3):383-6 18035408 - Cell. 2007 Nov 30;131(5):861-72 19564635 - Blood. 2009 Aug 27;114(9):1764-7 19299331 - Blood. 2009 May 28;113(22):5476-9 12898521 - J Cell Biochem. 2003 Aug 15;89(6):1235-49 19668191 - Nature. 2009 Aug 27;460(7259):1132-5 20497033 - Stem Cells Dev. 2011 Jan;20(1):159-68 21445094 - Cell Res. 2011 Jun;21(6):884-94 21474102 - Cell Stem Cell. 2011 Apr 8;8(4):376-88 20888316 - Cell Stem Cell. 2010 Nov 5;7(5):618-30 16904174 - Cell. 2006 Aug 25;126(4):663-76 19203577 - Cell. 2009 Feb 6;136(3):411-9 18276851 - Science. 2008 Aug 1;321(5889):699-702
References_xml	– volume: 113 start-page: 5476 year: 2009 end-page: 5479 ident: CR13 article-title: Generation of induced pluripotent stem cells from human blood publication-title: Blood doi: 10.1182/blood-2009-02-204800 – volume: 7 start-page: 618 year: 2010 end-page: 630 ident: CR21 article-title: Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA publication-title: Cell Stem Cell doi: 10.1016/j.stem.2010.08.012 – volume: 19 start-page: 229 year: 2010 end-page: 238 ident: CR11 article-title: Generation of induced pluripotent stem cells by efficient reprogramming of adult bone marrow cells publication-title: Stem Cells Dev doi: 10.1089/scd.2009.0149 – volume: 134 start-page: 877 year: 2008 end-page: 886 ident: CR17 article-title: Disease-specific induced pluripotent stem cells publication-title: Cell doi: 10.1016/j.cell.2008.07.041 – volume: 3 start-page: 475 year: 2008 end-page: 479 ident: CR24 article-title: Two supporting factors greatly improve the efficiency of human iPSC generation publication-title: Cell Stem Cell doi: 10.1016/j.stem.2008.10.002 – volume: 20 start-page: 159 year: 2011 end-page: 168 ident: CR12 article-title: Direct generation of induced pluripotent stem cells from human nonmobilized blood publication-title: Stem Cells Dev doi: 10.1089/scd.2010.0063 – volume: 460 start-page: 1140 year: 2009 end-page: 1144 ident: CR9 article-title: Linking the p53 tumour suppressor pathway to somatic cell reprogramming publication-title: Nature doi: 10.1038/nature08311 – volume: 26 start-page: 1998 year: 2008 end-page: 2005 ident: CR14 article-title: Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts publication-title: Stem Cells doi: 10.1634/stemcells.2008-0346 – volume: 18 start-page: 890 year: 2008 end-page: 894 ident: CR18 article-title: Reprogramming of pancreatic beta cells into induced pluripotent stem cells publication-title: Curr Biol doi: 10.1016/j.cub.2008.05.010 – volume: 321 start-page: 699 year: 2008 end-page: 702 ident: CR2 article-title: Generation of pluripotent stem cells from adult mouse liver and stomach cells publication-title: Science doi: 10.1126/science.1154884 – volume: 460 start-page: 1132 year: 2009 end-page: 1135 ident: CR8 article-title: Suppression of induced pluripotent stem cell generation by the p53-p21 pathway publication-title: Nature doi: 10.1038/nature08235 – volume: 8 start-page: 376 year: 2011 end-page: 388 ident: CR1 article-title: Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency publication-title: Cell Stem Cell doi: 10.1016/j.stem.2011.03.001 – volume: 106 start-page: 12759 year: 2009 end-page: 12764 ident: CR16 article-title: Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0904825106 – volume: 114 start-page: 1764 year: 2009 end-page: 1767 ident: CR15 article-title: Definitive proof for direct reprogramming of hematopoietic cells to pluripotency publication-title: Blood doi: 10.1182/blood-2009-02-203695 – volume: 21 start-page: 884 year: 2011 end-page: 894 ident: CR4 article-title: Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics publication-title: Cell Res doi: 10.1038/cr.2011.51 – volume: 89 start-page: 1235 year: 2003 end-page: 1249 ident: CR3 article-title: Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection publication-title: J Cell Biochem doi: 10.1002/jcb.10594 – volume: 126 start-page: 663 year: 2006 end-page: 676 ident: CR20 article-title: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors publication-title: Cell doi: 10.1016/j.cell.2006.07.024 – volume: 6 start-page: 71 year: 2010 end-page: 79 ident: CR6 article-title: Vitamin C enhances the generation of mouse and human induced pluripotent stem cells publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.12.001 – volume: 133 start-page: 250 year: 2008 end-page: 264 ident: CR7 article-title: Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency publication-title: Cell doi: 10.1016/j.cell.2008.03.028 – volume: 131 start-page: 861 year: 2007 end-page: 872 ident: CR19 article-title: Induction of pluripotent stem cells from adult human fibroblasts by defined factors publication-title: Cell doi: 10.1016/j.cell.2007.11.019 – volume: 31 start-page: 1872 year: 2007 end-page: 1882 ident: CR22 article-title: Reversal of diabetes in mice by intrahepatic injection of bone-derived GFP-murine mesenchymal stem cells infected with the recombinant retrovirus-carrying human insulin gene publication-title: World J Surg doi: 10.1007/s00268-007-9168-2 – volume: 26 start-page: 2467 year: 2008 end-page: 2474 ident: CR5 article-title: Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression publication-title: Stem Cells doi: 10.1634/stemcells.2008-0317 – volume: 20 start-page: 383 year: 2010 end-page: 386 ident: CR23 article-title: Efficient and rapid generation of induced pluripotent stem cells using an alternative culture medium publication-title: Cell Res doi: 10.1038/cr.2010.26 – volume: 136 start-page: 411 year: 2009 end-page: 419 ident: CR10 article-title: Oct4-induced pluripotency in adult neural stem cells publication-title: Cell doi: 10.1016/j.cell.2009.01.023 – volume: 133 start-page: 250 year: 2008 ident: 9493_CR7 publication-title: Cell doi: 10.1016/j.cell.2008.03.028 – volume: 26 start-page: 1998 year: 2008 ident: 9493_CR14 publication-title: Stem Cells doi: 10.1634/stemcells.2008-0346 – volume: 31 start-page: 1872 year: 2007 ident: 9493_CR22 publication-title: World J Surg doi: 10.1007/s00268-007-9168-2 – volume: 321 start-page: 699 year: 2008 ident: 9493_CR2 publication-title: Science doi: 10.1126/science.1154884 – volume: 460 start-page: 1140 year: 2009 ident: 9493_CR9 publication-title: Nature doi: 10.1038/nature08311 – volume: 113 start-page: 5476 year: 2009 ident: 9493_CR13 publication-title: Blood doi: 10.1182/blood-2009-02-204800 – volume: 136 start-page: 411 year: 2009 ident: 9493_CR10 publication-title: Cell doi: 10.1016/j.cell.2009.01.023 – volume: 18 start-page: 890 year: 2008 ident: 9493_CR18 publication-title: Curr Biol doi: 10.1016/j.cub.2008.05.010 – volume: 20 start-page: 383 year: 2010 ident: 9493_CR23 publication-title: Cell Res doi: 10.1038/cr.2010.26 – volume: 26 start-page: 2467 year: 2008 ident: 9493_CR5 publication-title: Stem Cells doi: 10.1634/stemcells.2008-0317 – volume: 114 start-page: 1764 year: 2009 ident: 9493_CR15 publication-title: Blood doi: 10.1182/blood-2009-02-203695 – volume: 126 start-page: 663 year: 2006 ident: 9493_CR20 publication-title: Cell doi: 10.1016/j.cell.2006.07.024 – volume: 134 start-page: 877 year: 2008 ident: 9493_CR17 publication-title: Cell doi: 10.1016/j.cell.2008.07.041 – volume: 19 start-page: 229 year: 2010 ident: 9493_CR11 publication-title: Stem Cells Dev doi: 10.1089/scd.2009.0149 – volume: 106 start-page: 12759 year: 2009 ident: 9493_CR16 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0904825106 – volume: 21 start-page: 884 year: 2011 ident: 9493_CR4 publication-title: Cell Res doi: 10.1038/cr.2011.51 – volume: 20 start-page: 159 year: 2011 ident: 9493_CR12 publication-title: Stem Cells Dev doi: 10.1089/scd.2010.0063 – volume: 460 start-page: 1132 year: 2009 ident: 9493_CR8 publication-title: Nature doi: 10.1038/nature08235 – volume: 131 start-page: 861 year: 2007 ident: 9493_CR19 publication-title: Cell doi: 10.1016/j.cell.2007.11.019 – volume: 7 start-page: 618 year: 2010 ident: 9493_CR21 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2010.08.012 – volume: 89 start-page: 1235 year: 2003 ident: 9493_CR3 publication-title: J Cell Biochem doi: 10.1002/jcb.10594 – volume: 6 start-page: 71 year: 2010 ident: 9493_CR6 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.12.001 – volume: 8 start-page: 376 year: 2011 ident: 9493_CR1 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2011.03.001 – volume: 3 start-page: 475 year: 2008 ident: 9493_CR24 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2008.10.002 – reference: 12898521 - J Cell Biochem. 2003 Aug 15;89(6):1235-49 – reference: 16904174 - Cell. 2006 Aug 25;126(4):663-76 – reference: 19299331 - Blood. 2009 May 28;113(22):5476-9 – reference: 21445094 - Cell Res. 2011 Jun;21(6):884-94 – reference: 20888316 - Cell Stem Cell. 2010 Nov 5;7(5):618-30 – reference: 19558219 - Stem Cells Dev. 2010 Feb;19(2):229-38 – reference: 18511599 - Stem Cells. 2008 Aug;26(8):1998-2005 – reference: 19203577 - Cell. 2009 Feb 6;136(3):411-9 – reference: 18983962 - Cell Stem Cell. 2008 Nov 6;3(5):475-9 – reference: 18276851 - Science. 2008 Aug 1;321(5889):699-702 – reference: 21474102 - Cell Stem Cell. 2011 Apr 8;8(4):376-88 – reference: 20497033 - Stem Cells Dev. 2011 Jan;20(1):159-68 – reference: 19668186 - Nature. 2009 Aug 27;460(7259):1140-4 – reference: 17653584 - World J Surg. 2007 Sep;31(9):1872-82 – reference: 18501604 - Curr Biol. 2008 Jun 24;18(12):890-4 – reference: 19564635 - Blood. 2009 Aug 27;114(9):1764-7 – reference: 19549847 - Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12759-64 – reference: 18691744 - Cell. 2008 Sep 5;134(5):877-86 – reference: 19668191 - Nature. 2009 Aug 27;460(7259):1132-5 – reference: 20036631 - Cell Stem Cell. 2010 Jan 8;6(1):71-9 – reference: 18035408 - Cell. 2007 Nov 30;131(5):861-72 – reference: 18635867 - Stem Cells. 2008 Oct;26(10):2467-74 – reference: 20157334 - Cell Res. 2010 Mar;20(3):383-6 – reference: 18423197 - Cell. 2008 Apr 18;133(2):250-64
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Snippet	Induced pluripotent stem cells have been derived from various cell types via the ectopic expression of a cocktail of transcription factors. Previous studies...
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SubjectTerms	Alkaline phosphatase Animal Genetics and Genomics Animals Antigens, CD Antigens, CD - metabolism Biomedical and Life Sciences Blood cells Bone marrow Bone marrow cells Bone Marrow Cells - cytology Bone Marrow Cells - metabolism CELL AND TISSUE MODELS Cell Biology Cell Culture Cell Culture Techniques Cell Differentiation Cellular Reprogramming clones cytology Developmental Biology Embryo cells Embryo fibroblasts Embryonic stem cells Enumeration Feeder cells fibroblasts Fibroblasts - cytology Induced pluripotent stem cells Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Inhibitory postsynaptic potentials Leukocytes (mononuclear) Life Sciences medicine Mesenchymal Stem Cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mesenchyme metabolism Mice Pluripotent Stem Cells Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Regeneration Somatic cells Stem Cells T lymphocytes teratoma Transcription factors
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Title	Comparing the reprogramming efficiency of mouse embryonic fibroblasts, mouse bone marrow mesenchymal stem cells and bone marrow mononuclear cells to iPSCs
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