Improved recognition of native-like protein structures using a family of designed sequences

The goal of the inverse protein folding problem is to identify amino acid sequences that stabilize a given target protein conformation. Methods that attempt to solve this problem have proven useful for protein sequence design. Here we show that the same methods can provide valuable information for p...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 99; H. 2; S. 691
Hauptverfasser:	Koehl, Patrice, Levitt, Michael
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 22.01.2002
Schlagworte:	Amino Acid Sequence Biophysical Phenomena Biophysics Drug Design Protein Conformation Protein Folding Proteins - chemistry Thermodynamics
ISSN:	0027-8424
Online-Zugang:	Weitere Angaben
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