OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. Several OTU DUBs were reported to be ubiquitin (Ub) chain linkage specific, but comprehensive analyses are missing, and the underlying mechanisms of linkage specificity are u...

Full description

Saved in:

Bibliographic Details
Published in:	Cell Vol. 154; no. 1; p. 169
Main Authors:	Mevissen, Tycho E T, Hospenthal, Manuela K, Geurink, Paul P, Elliott, Paul R, Akutsu, Masato, Arnaudo, Nadia, Ekkebus, Reggy, Kulathu, Yogesh, Wauer, Tobias, El Oualid, Farid, Freund, Stefan M V, Ovaa, Huib, Komander, David
Format:	Journal Article
Language:	English
Published:	United States 03.07.2013
Subjects:	Catalysis Catalytic Domain Crystallography, X-Ray Endopeptidases - chemistry Endopeptidases - genetics Endopeptidases - metabolism Female Humans Models, Molecular Ovarian Neoplasms - enzymology Ovarian Neoplasms - metabolism Protein Structure, Tertiary Thiolester Hydrolases - chemistry Thiolester Hydrolases - metabolism Ubiquitination Ubiquitins - metabolism
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!