OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. Several OTU DUBs were reported to be ubiquitin (Ub) chain linkage specific, but comprehensive analyses are missing, and the underlying mechanisms of linkage specificity are u...

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Veröffentlicht in:	Cell Jg. 154; H. 1; S. 169
Hauptverfasser:	Mevissen, Tycho E T, Hospenthal, Manuela K, Geurink, Paul P, Elliott, Paul R, Akutsu, Masato, Arnaudo, Nadia, Ekkebus, Reggy, Kulathu, Yogesh, Wauer, Tobias, El Oualid, Farid, Freund, Stefan M V, Ovaa, Huib, Komander, David
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 03.07.2013
Schlagworte:	Catalysis Catalytic Domain Crystallography, X-Ray Endopeptidases - chemistry Endopeptidases - genetics Endopeptidases - metabolism Female Humans Models, Molecular Ovarian Neoplasms - enzymology Ovarian Neoplasms - metabolism Protein Structure, Tertiary Thiolester Hydrolases - chemistry Thiolester Hydrolases - metabolism Ubiquitination Ubiquitins - metabolism
ISSN:	1097-4172, 1097-4172
Online-Zugang:	Weitere Angaben
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