Antiviral activity of berberine

Plants are a rich source of new antiviral, pharmacologically active agents. The naturally occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of biological activity, including anticancer, anti-inflammatory and antiviral activity. BBR targets different steps in th...

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Podrobná bibliografie
Vydáno v:	Archives of virology Ročník 165; číslo 9; s. 1935 - 1945
Hlavní autoři:	Warowicka, Alicja, Nawrot, Robert, Goździcka-Józefiak, Anna
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Vienna Springer Vienna 01.09.2020 Springer Nature B.V
Témata:	Antiviral activity Antiviral agents Antiviral drugs antiviral properties Berberine Biological activity Biomedical and Life Sciences Biomedicine COVID-19 COVID-19 infection Deoxyribonucleic acid DNA DNA biosynthesis DNA replication Drug development Herpes simplex HIV Human betaherpesvirus 5 Human immunodeficiency virus Human papillomavirus humans Immune clearance Immune response Immunosuppressive agents Infectious Diseases Inflammation Intercalating agents Life cycles Medical Microbiology medicinal properties NF-κB protein pandemic Pandemics Papillomaviridae phytochemicals Replication Review RNA-directed DNA polymerase Severe acute respiratory syndrome coronavirus 2 TOR protein Virology virus replication viruses
ISSN:	0304-8608, 1432-8798, 1432-8798
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Plants are a rich source of new antiviral, pharmacologically active agents. The naturally occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of biological activity, including anticancer, anti-inflammatory and antiviral activity. BBR targets different steps in the viral life cycle and is thus a good candidate for use in novel antiviral drugs and therapies. It has been shown that BBR reduces virus replication and targets specific interactions between the virus and its host. BBR intercalates into DNA and inhibits DNA synthesis and reverse transcriptase activity. It inhibits replication of herpes simplex virus (HSV), human cytomegalovirus (HCMV), human papillomavirus (HPV), and human immunodeficiency virus (HIV). This isoquinoline alkaloid has the ability to regulate the MEK-ERK, AMPK/mTOR, and NF-κB signaling pathways, which are necessary for viral replication. Furthermore, it has been reported that BBR supports the host immune response, thus leading to viral clearance. In this short review, we focus on the most recent studies on the antiviral properties of berberine and its derivatives, which might be promising agents to be considered in future studies in the fight against the current pandemic SARS-CoV-2, the virus that causes COVID-19.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Handling Editor: Carolina Scagnolari.
ISSN:	0304-8608 1432-8798 1432-8798
DOI:	10.1007/s00705-020-04706-3