Antiviral activity of berberine

Plants are a rich source of new antiviral, pharmacologically active agents. The naturally occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of biological activity, including anticancer, anti-inflammatory and antiviral activity. BBR targets different steps in th...

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Published in:	Archives of virology Vol. 165; no. 9; pp. 1935 - 1945
Main Authors:	Warowicka, Alicja, Nawrot, Robert, Goździcka-Józefiak, Anna
Format:	Journal Article
Language:	English
Published:	Vienna Springer Vienna 01.09.2020 Springer Nature B.V
Subjects:	Antiviral activity Antiviral agents Antiviral drugs antiviral properties Berberine Biological activity Biomedical and Life Sciences Biomedicine COVID-19 COVID-19 infection Deoxyribonucleic acid DNA DNA biosynthesis DNA replication Drug development Herpes simplex HIV Human betaherpesvirus 5 Human immunodeficiency virus Human papillomavirus humans Immune clearance Immune response Immunosuppressive agents Infectious Diseases Inflammation Intercalating agents Life cycles Medical Microbiology medicinal properties NF-κB protein pandemic Pandemics Papillomaviridae phytochemicals Replication Review RNA-directed DNA polymerase Severe acute respiratory syndrome coronavirus 2 TOR protein Virology virus replication viruses
ISSN:	0304-8608, 1432-8798, 1432-8798
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Abstract	Plants are a rich source of new antiviral, pharmacologically active agents. The naturally occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of biological activity, including anticancer, anti-inflammatory and antiviral activity. BBR targets different steps in the viral life cycle and is thus a good candidate for use in novel antiviral drugs and therapies. It has been shown that BBR reduces virus replication and targets specific interactions between the virus and its host. BBR intercalates into DNA and inhibits DNA synthesis and reverse transcriptase activity. It inhibits replication of herpes simplex virus (HSV), human cytomegalovirus (HCMV), human papillomavirus (HPV), and human immunodeficiency virus (HIV). This isoquinoline alkaloid has the ability to regulate the MEK-ERK, AMPK/mTOR, and NF-κB signaling pathways, which are necessary for viral replication. Furthermore, it has been reported that BBR supports the host immune response, thus leading to viral clearance. In this short review, we focus on the most recent studies on the antiviral properties of berberine and its derivatives, which might be promising agents to be considered in future studies in the fight against the current pandemic SARS-CoV-2, the virus that causes COVID-19.
AbstractList	Plants are a rich source of new antiviral, pharmacologically active agents. The naturally occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of biological activity, including anticancer, anti-inflammatory and antiviral activity. BBR targets different steps in the viral life cycle and is thus a good candidate for use in novel antiviral drugs and therapies. It has been shown that BBR reduces virus replication and targets specific interactions between the virus and its host. BBR intercalates into DNA and inhibits DNA synthesis and reverse transcriptase activity. It inhibits replication of herpes simplex virus (HSV), human cytomegalovirus (HCMV), human papillomavirus (HPV), and human immunodeficiency virus (HIV). This isoquinoline alkaloid has the ability to regulate the MEK-ERK, AMPK/mTOR, and NF-κB signaling pathways, which are necessary for viral replication. Furthermore, it has been reported that BBR supports the host immune response, thus leading to viral clearance. In this short review, we focus on the most recent studies on the antiviral properties of berberine and its derivatives, which might be promising agents to be considered in future studies in the fight against the current pandemic SARS-CoV-2, the virus that causes COVID-19. Plants are a rich source of new antiviral, pharmacologically active agents. The naturally occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of biological activity, including anticancer, anti-inflammatory and antiviral activity. BBR targets different steps in the viral life cycle and is thus a good candidate for use in novel antiviral drugs and therapies. It has been shown that BBR reduces virus replication and targets specific interactions between the virus and its host. BBR intercalates into DNA and inhibits DNA synthesis and reverse transcriptase activity. It inhibits replication of herpes simplex virus (HSV), human cytomegalovirus (HCMV), human papillomavirus (HPV), and human immunodeficiency virus (HIV). This isoquinoline alkaloid has the ability to regulate the MEK-ERK, AMPK/mTOR, and NF-κB signaling pathways, which are necessary for viral replication. Furthermore, it has been reported that BBR supports the host immune response, thus leading to viral clearance. In this short review, we focus on the most recent studies on the antiviral properties of berberine and its derivatives, which might be promising agents to be considered in future studies in the fight against the current pandemic SARS-CoV-2, the virus that causes COVID-19.Plants are a rich source of new antiviral, pharmacologically active agents. The naturally occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of biological activity, including anticancer, anti-inflammatory and antiviral activity. BBR targets different steps in the viral life cycle and is thus a good candidate for use in novel antiviral drugs and therapies. It has been shown that BBR reduces virus replication and targets specific interactions between the virus and its host. BBR intercalates into DNA and inhibits DNA synthesis and reverse transcriptase activity. It inhibits replication of herpes simplex virus (HSV), human cytomegalovirus (HCMV), human papillomavirus (HPV), and human immunodeficiency virus (HIV). This isoquinoline alkaloid has the ability to regulate the MEK-ERK, AMPK/mTOR, and NF-κB signaling pathways, which are necessary for viral replication. Furthermore, it has been reported that BBR supports the host immune response, thus leading to viral clearance. In this short review, we focus on the most recent studies on the antiviral properties of berberine and its derivatives, which might be promising agents to be considered in future studies in the fight against the current pandemic SARS-CoV-2, the virus that causes COVID-19.
Author	Nawrot, Robert Goździcka-Józefiak, Anna Warowicka, Alicja
Author_xml	– sequence: 1 givenname: Alicja orcidid: 0000-0003-4301-9855 surname: Warowicka fullname: Warowicka, Alicja email: alicja@amu.edu.pl organization: Department of Animal Physiology and Developmental Biology, Institute of Experimental Biology, Faculty of Biology, Adam Mickiewicz University, NanoBioMedical Centre, Adam Mickiewicz University – sequence: 2 givenname: Robert surname: Nawrot fullname: Nawrot, Robert organization: Molecular Virology Research Unit, Institute of Experimental Biology, Faculty of Biology, Adam Mickiewicz University – sequence: 3 givenname: Anna surname: Goździcka-Józefiak fullname: Goździcka-Józefiak, Anna organization: Molecular Virology Research Unit, Institute of Experimental Biology, Faculty of Biology, Adam Mickiewicz University
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Snippet	Plants are a rich source of new antiviral, pharmacologically active agents. The naturally occurring plant alkaloid berberine (BBR) is one of the phytochemicals...
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SubjectTerms	Antiviral activity Antiviral agents Antiviral drugs antiviral properties Berberine Biological activity Biomedical and Life Sciences Biomedicine COVID-19 COVID-19 infection Deoxyribonucleic acid DNA DNA biosynthesis DNA replication Drug development Herpes simplex HIV Human betaherpesvirus 5 Human immunodeficiency virus Human papillomavirus humans Immune clearance Immune response Immunosuppressive agents Infectious Diseases Inflammation Intercalating agents Life cycles Medical Microbiology medicinal properties NF-κB protein pandemic Pandemics Papillomaviridae phytochemicals Replication Review RNA-directed DNA polymerase Severe acute respiratory syndrome coronavirus 2 TOR protein Virology virus replication viruses
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Title	Antiviral activity of berberine
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