Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan

This study investigated the preventive effects of lactoferrin (LF) on subjective acute gastrointestinal symptoms during the winter in a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The eligible subjects were healthy adults working at kindergartens and nursery scho...

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Vydané v:International journal of environmental research and public health Ročník 17; číslo 24; s. 9582
Hlavní autori: Mizuki, Masaru, Tsukahara, Teruomi, Oda, Hirotsugu, Tanaka, Miyuki, Yamauchi, Koji, Abe, Fumiaki, Nomiyama, Tetsuo
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 21.12.2020
MDPI
Predmet:
Adult
Anti-Infective Agents - therapeutic use
Day care centers
Double-Blind Method
Female
Food products
Gastroenteritis
Gastrointestinal Diseases - drug therapy
Gastrointestinal Diseases - epidemiology
Gastrointestinal Diseases - prevention & control
Health care
Humans
Infectious diseases
Informed consent
Japan - epidemiology
Lactoferrin - therapeutic use
Milk
Preventive medicine
Public health
Questionnaires
Schools
Schools, Nursery
Small intestine
Statistical analysis
Trends
Japan
lactoferrin
subjective acute gastrointestinal symptoms
winter
kindergarten
diarrhea
ISSN:1660-4601, 1661-7827, 1660-4601
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Abstract This study investigated the preventive effects of lactoferrin (LF) on subjective acute gastrointestinal symptoms during the winter in a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The eligible subjects were healthy adults working at kindergartens and nursery schools. We randomized the subjects to the Placebo group (0 mg/day), the Low LF group (200 mg/day), and the High LF group (600 mg/day) for 12 weeks. The prevalence of acute gastrointestinal symptoms was significantly lower in the High LF (13/112 vs. 26/116; p = 0.030) and the Low LF (13/107 vs. 26/116; p = 0.040) groups than in the Placebo group. The adjusted odds ratio for the prevalence of acute gastrointestinal symptoms was 2.78 (95% CI: 1.19–6.47) in the Placebo group compared with the High LF group. LF is useful to prevent acute gastrointestinal symptoms among childcare workers, who mainly consist of women.
AbstractList This study investigated the preventive effects of lactoferrin (LF) on subjective acute gastrointestinal symptoms during the winter in a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The eligible subjects were healthy adults working at kindergartens and nursery schools. We randomized the subjects to the Placebo group (0 mg/day), the Low LF group (200 mg/day), and the High LF group (600 mg/day) for 12 weeks. The prevalence of acute gastrointestinal symptoms was significantly lower in the High LF (13/112 vs. 26/116; = 0.030) and the Low LF (13/107 vs. 26/116; = 0.040) groups than in the Placebo group. The adjusted odds ratio for the prevalence of acute gastrointestinal symptoms was 2.78 (95% CI: 1.19-6.47) in the Placebo group compared with the High LF group. LF is useful to prevent acute gastrointestinal symptoms among childcare workers, who mainly consist of women.
This study investigated the preventive effects of lactoferrin (LF) on subjective acute gastrointestinal symptoms during the winter in a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The eligible subjects were healthy adults working at kindergartens and nursery schools. We randomized the subjects to the Placebo group (0 mg/day), the Low LF group (200 mg/day), and the High LF group (600 mg/day) for 12 weeks. The prevalence of acute gastrointestinal symptoms was significantly lower in the High LF (13/112 vs. 26/116; p = 0.030) and the Low LF (13/107 vs. 26/116; p = 0.040) groups than in the Placebo group. The adjusted odds ratio for the prevalence of acute gastrointestinal symptoms was 2.78 (95% CI: 1.19–6.47) in the Placebo group compared with the High LF group. LF is useful to prevent acute gastrointestinal symptoms among childcare workers, who mainly consist of women.
This study investigated the preventive effects of lactoferrin (LF) on subjective acute gastrointestinal symptoms during the winter in a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The eligible subjects were healthy adults working at kindergartens and nursery schools. We randomized the subjects to the Placebo group (0 mg/day), the Low LF group (200 mg/day), and the High LF group (600 mg/day) for 12 weeks. The prevalence of acute gastrointestinal symptoms was significantly lower in the High LF (13/112 vs. 26/116; p = 0.030) and the Low LF (13/107 vs. 26/116; p = 0.040) groups than in the Placebo group. The adjusted odds ratio for the prevalence of acute gastrointestinal symptoms was 2.78 (95% CI: 1.19-6.47) in the Placebo group compared with the High LF group. LF is useful to prevent acute gastrointestinal symptoms among childcare workers, who mainly consist of women.This study investigated the preventive effects of lactoferrin (LF) on subjective acute gastrointestinal symptoms during the winter in a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The eligible subjects were healthy adults working at kindergartens and nursery schools. We randomized the subjects to the Placebo group (0 mg/day), the Low LF group (200 mg/day), and the High LF group (600 mg/day) for 12 weeks. The prevalence of acute gastrointestinal symptoms was significantly lower in the High LF (13/112 vs. 26/116; p = 0.030) and the Low LF (13/107 vs. 26/116; p = 0.040) groups than in the Placebo group. The adjusted odds ratio for the prevalence of acute gastrointestinal symptoms was 2.78 (95% CI: 1.19-6.47) in the Placebo group compared with the High LF group. LF is useful to prevent acute gastrointestinal symptoms among childcare workers, who mainly consist of women.
Author Yamauchi, Koji
Tsukahara, Teruomi
Oda, Hirotsugu
Tanaka, Miyuki
Abe, Fumiaki
Mizuki, Masaru
Nomiyama, Tetsuo
AuthorAffiliation 1 Department of Occupational Medicine, School of Medicine, Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan; mizuki@shinshu-u.ac.jp (M.M.); nomiyama@shinshu-u.ac.jp (T.N.)
3 Food Ingredients and Technology Institute, R&D Division, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa 252-8583, Japan; h-oda@morinagamilk.co.jp (H.O.); m_tanaka@morinagamilk.co.jp (M.T.); ko_yamau@morinagamilk.co.jp (K.Y.); f_abe@morinagamilk.co.jp (F.A.)
2 Department of Preventive Medicine and Public Health, School of Medicine, Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan
AuthorAffiliation_xml – name: 1 Department of Occupational Medicine, School of Medicine, Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan; mizuki@shinshu-u.ac.jp (M.M.); nomiyama@shinshu-u.ac.jp (T.N.)
– name: 2 Department of Preventive Medicine and Public Health, School of Medicine, Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan
– name: 3 Food Ingredients and Technology Institute, R&D Division, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa 252-8583, Japan; h-oda@morinagamilk.co.jp (H.O.); m_tanaka@morinagamilk.co.jp (M.T.); ko_yamau@morinagamilk.co.jp (K.Y.); f_abe@morinagamilk.co.jp (F.A.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33371454$$D View this record in MEDLINE/PubMed
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Issue 24
Keywords lactoferrin
subjective acute gastrointestinal symptoms
winter
kindergarten
diarrhea
Language English
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Snippet This study investigated the preventive effects of lactoferrin (LF) on subjective acute gastrointestinal symptoms during the winter in a randomized,...
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StartPage 9582
SubjectTerms Adult
Anti-Infective Agents - therapeutic use
Day care centers
Double-Blind Method
Female
Food products
Gastroenteritis
Gastrointestinal Diseases - drug therapy
Gastrointestinal Diseases - epidemiology
Gastrointestinal Diseases - prevention & control
Health care
Humans
Infectious diseases
Informed consent
Japan - epidemiology
Lactoferrin - therapeutic use
Milk
Preventive medicine
Public health
Questionnaires
Schools
Schools, Nursery
Small intestine
Statistical analysis
Trends
Title Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan
URI https://www.ncbi.nlm.nih.gov/pubmed/33371454
https://www.proquest.com/docview/2473439253
https://www.proquest.com/docview/2473742388
https://pubmed.ncbi.nlm.nih.gov/PMC7767418
Volume 17
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