Mycetoma: An update

Mycetoma is a localized chronic, suppurative, and deforming granulomatous infection seen in tropical and subtropical areas. It is a disorder of subcutaneous tissue, skin and bones, mainly of feet, characterized by a triad of localized swelling, underlying sinus tracts, and production of grains or gr...

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Bibliographic Details
Published in:Indian journal of dermatology Vol. 62; no. 4; pp. 332 - 340
Main Authors: Relhan, Vineet, Mahajan, Khushbu, Agarwal, Pooja, Garg, VijayKumar
Format: Journal Article
Language:English
Published: India Medknow Publications & Media Pvt. Ltd 01.07.2017
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects:
Actinomycetoma
Antibiotics
Antifungal agents
Antigens
Dermatology
eumycetoma
Fungi
Immunoglobulins
Infections
Madura foot
Neutrophils
Organisms
Pathogenesis
Review
Mexico
Sudan
Yemen
India
eumycetoma
Madura foot
Actinomycetoma
ISSN:0019-5154, 1998-3611, 1998-3611
Online Access:Get full text
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Summary:Mycetoma is a localized chronic, suppurative, and deforming granulomatous infection seen in tropical and subtropical areas. It is a disorder of subcutaneous tissue, skin and bones, mainly of feet, characterized by a triad of localized swelling, underlying sinus tracts, and production of grains or granules. Etiological classification divides it into eumycetoma caused by fungus, and actinomycetoma caused by bacteria. Since the treatment of these two etiologies is entirely different, a definite diagnosis after histopathological and microbiological examination is mandatory, though difficult. Serological test exists but is not so reliable; however, molecular techniques to identify relevant antigens have shown promise. The disease is notoriously difficult to treat. Eumycetoma may be unresponsive to standard antifungal therapy. Actinomycetoma responds to antibiotic therapy, but prolonged treatment is necessary. This review focuses on the etiopathogenesis, clinical features, laboratory diagnosis, and treatment of mycetoma.
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ISSN:0019-5154
1998-3611
1998-3611
DOI:10.4103/ijd.IJD_476_16