Mitochondrial bioenergetic function and metabolic plasticity in stem cell differentiation and cellular reprogramming

The self-renewal ability and pluripotent differentiation potential of stem cells hold great promise for regenerative medicine. Many studies focus on the lineage-specific differentiation and expansion of stem cells, but little is known about the regulation of glycolysis and mitochondrial biogenesis a...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1820; no. 5; pp. 571 - 576
Main Authors:	Chen, Chien-Tsun, Hsu, Shu-Han, Wei, Yau-Huei
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.05.2012
Subjects:	Animals biogenesis Cell Differentiation cells Cellular Reprogramming Energy Metabolism glycolysis Humans induced pluripotent stem cells Metabolic shift Mitochondria Mitochondria - metabolism Pluripotency Stem cells Stem Cells - cytology Stem Cells - metabolism Metabolic shift HIF mtDNA TSC Ψm iPSC Cell differentiation PHD bFGF Cellular reprogramming Mitochondria ESC NOX ROS Stem cells mTOR HSC Pol γ VHL MSC mtTFA Pluripotency NSC
ISSN:	0304-4165, 0006-3002, 1872-8006
Online Access:	Get full text
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