Nucleic Acid Testing to Detect HBV Infection in Blood Donors

In this study involving 3.7 million blood donors, nucleic acid testing identified 9 donors with HBV infection who were not identified by routine serologic testing. The single triplex assay also identified 2 donors with HIV and 15 with HCV. The transfusion of blood containing hepatitis B surface anti...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 364; no. 3; pp. 236 - 247
Main Authors: Stramer, Susan L, Wend, Ulrike, Candotti, Daniel, Foster, Gregory A, Hollinger, F. Blaine, Dodd, Roger Y, Allain, Jean-Pierre, Gerlich, Wolfram
Format: Journal Article
Language:English
Published: Waltham, MA Massachusetts Medical Society 20.01.2011
Subjects:
Biological and medical sciences
Blood Donors
Disease Transmission, Infectious
DNA, Viral - blood
Follow-Up Studies
General aspects
Genotype
Hepatitis B - diagnosis
Hepatitis B Antibodies - blood
Hepatitis B Core Antigens - blood
Hepatitis B Surface Antigens - blood
Hepatitis B Surface Antigens - immunology
Hepatitis B virus - genetics
Hepatitis B virus - isolation & purification
HIV - genetics
HIV - isolation & purification
Human viral diseases
Humans
Infectious diseases
Medical sciences
Nucleic Acid Amplification Techniques
Phylogeny
Polymerase Chain Reaction
Prevention and actions
Public health. Hygiene
Public health. Hygiene-occupational medicine
RNA, Viral - blood
Sexual Partners
Testing laboratories
Tropical diseases
Viral diseases
Viral hepatitis
Viral Load
Infection
Human
Viral hepatitis B
Medicine
Viral disease
Digestive diseases
Hepatic disease
Medical screening
Detection
Nucleic acid
Blood donor
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Summary:In this study involving 3.7 million blood donors, nucleic acid testing identified 9 donors with HBV infection who were not identified by routine serologic testing. The single triplex assay also identified 2 donors with HIV and 15 with HCV. The transfusion of blood containing hepatitis B surface antigen (HBsAg) is associated with post-transfusion infection with hepatitis B virus (HBV). Blood that is free of HBsAg but has high-titer antibodies against hepatitis B core antigen (anti-HBc) in the absence of antibodies against hepatitis B surface antigen (anti-HBs) can also transmit HBV infection. 1 , 2 In 1986, screening for anti-HBc was implemented in the United States to reduce HBV transmission and as a surrogate marker for non-A, non-B hepatitis (i.e., hepatitis C virus [HCV]). 3 , 4 However, a small proportion of donors with anti-HBc in the absence of HBsAg have circulating HBV DNA . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1007644